Formal pharmacokinetic trials using Flixonase propionate nasal spray have not been conducted in subjects with renal impairment.
The recommended starting dosage in adults is 2 sprays (50 mcg of Flixonase propionate each) in each nostril once daily (total daily dose, 200 mcg). The same total daily dose, 1 spray in each nostril administered twice daily (e.g., 8 a.m. and 8 p.m.) is also effective. After the first few days, patients may be able to reduce their dose to 1 spray in each nostril once daily for maintenance therapy.
Maximum total daily doses should not exceed 2 sprays in each nostril (total dose, 200 mcg/day). There is no evidence that exceeding the recommended dose is more effective.
- fungal infections (thrush) in your mouth and throat. Tell your doctor if you have any redness or white-colored coating in your mouth
- decreased adrenal function (adrenal insufficiency). Symptoms of decreased adrenal function include tiredness, weakness, nausea and vomiting, and low blood pressure. Decreased adrenal function can lead to death.
- swelling of the face, throat and tongue
- breathing problems
- Nasal Spray
- nose problems. Nose problems may include:
- nose bleeds
- sores (ulcers) in your nose
- a certain fungal infection in your nose, mouth, and/or throat (thrush)
- hole in the cartilage of your nose (nasal septal perforation). Symptoms of nasal septal perforation may include:
Flixonase and Pregnancy
Tell your doctor if you are pregnant or plan to become pregnant.
The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.
Flixonase falls into category C. Studies in animals have shown a harmful and undesired effect on the unborn baby, yet there are no adequate and well-controlled studies in pregnant women.
This medication may be given to a pregnant woman if her healthcare provider believes that its benefits to the pregnant woman outweigh any possible risks to her unborn baby.
Uses of Flixonase
- Flixonase oral inhalation is a prescription medication used to prevent difficulty breathing, chest tightness, wheezing, and coughing caused by asthma.
- Flixonase nasal spray is a medication used to treat the symptoms of allergic and non-allergic rhinitis in patients aged 4 years and older. Symptoms may include:
- runny nose
- stuffy nose
- itchy nose
- itchy, watery eyes
- Flixonase cream, ointment, and lotion are prescription medications used to reduce inflammation and relieve itching, redness, dryness, and scaling associated with various skin conditions.
- This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
There are no available data on the presence of Flixonase propionate in human milk, the effects on the breastfed child, or the effects on milk production. Low concentrations of other corticosteroids have been detected in human milk. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for Flixonase propionate nasal spray and any potential adverse effects on the breastfed child from Flixonase propionate nasal spray or from the underlying maternal condition.
Animal Data : Subcutaneous administration of tritiated Flixonase propionate at a dose of 10 mcg/kg/day to lactating rats resulted in measurable levels in milk.
Indications and Usage for Flixonase Nasal Spray
Flixonase propionate nasal spray is indicated for the management of the nasal symptoms of perennial nonallergic rhinitis in adults and pediatric patients aged 4 years and older.
Psoriasis Studies: In 2 vehicle-controlled studies, Flixonase Propionate Cream applied twice daily was significantly more effective than the vehicle in the treatment of moderate to severe psoriasis. The investigator’s global evaluation after 28 days of treatment is shown in Table 3.
If you take too much this medication, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.
Formal pharmacokinetic trials using FLONASE Nasal Spray have not been conducted in subjects with hepatic impairment. Since Flixonase propionate is predominantly cleared by hepatic metabolism, impairment of liver function may lead to accumulation of Flixonase propionate in plasma. Therefore, patients with hepatic disease should be closely monitored.
- nose problems. Nose problems may include: