Other Etyzem Interactions
Grapefruit and grapefruit juice may interact with Etyzem. Your doctor may advise you to follow a low-sodium diet while taking Etyzem.
This medication may impair your thinking and reaction time. Be especially careful when driving or performing any activity that may require you to be alert.
You should also try to avoid exposure to sunlight or tanning beds. Etyzem can increase your skin's sensitivity to light and you may develop sunburns more easily.
Warnings for other groups
For pregnant women: Research in animals has shown adverse effects to the fetus when the mother takes the drug. There haven’t been enough studies done in humans to be certain how the drug might affect the pregnancy, however. Tell your doctor if you’re pregnant or plan to become pregnant. Etyzem should be used during pregnancy only if the potential benefit justifies the potential risk.
For women who are breastfeeding: Etyzem may pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your baby. You may need to decide whether to stop breastfeeding or stop taking this medication.
For seniors: Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal. If you’re a senior, you may need a lower dose or a different schedule.
For children: This medicine hasn’t been studied in children and shouldn’t be used in children under the age of 18 years.
This dosage information is for Etyzem oral capsules and oral tablets. All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:
- your age
- the condition being treated
- how severe your condition is
- other medical conditions you have
- how you react to the first dose
Mechanism of action
Etyzem slows AV conduction and prolongs the AV refractory period to a similar degree to verapamil. It has minimal effects on myocardial contractility at clinically relevant plasma concentrations in normal dogs. Etyzem's effects on peripheral vascular smooth muscle are mild, although it is a potent coronary vasodilator.
In normal experimental dogs, one study found that Etyzem (0.8 mg/kg IV) d > These effects resulted in increased cardiac output. In the same study in experimental dogs with pacing-induced myocardial failure, however, the effects were very different. In these dogs, Etyzem decreased myocardial contractility and did not change the heart rate. The net result was a decrease in cardiac output. Another study identified similar findings in dogs with left ventricular volume overload induced by creating an aortocaval fistula. Consequently, Etyzem must be administered cautiously to dogs with moderate to severe myocardial failure or heart failure.
Formulations and dose rates
The formulations of Etyzem available are discussed earlier in the chapter ( p. 423 ) as well as appropriate doses for cats.
To decrease ventricular rate in dogs with atrial fibrillation, an initial dose of 0.5 mg/kg q.8 h PO should be administered. If the heart rate does not decrease adequately, the dose can be increased to 1.0 mg/kg q.8 h PO and finally to 1.5 mg/kg q.8 h PO. In general, the heart rate should be decreased to less than 160 beats/min. At these doses, Etyzem appears to have no or negligible negative inotropic effects, since exacerbation of heart failure at this dose is rare
For acute termination of supraventricular tachycardia, a dose of 0.1–0.25 mg/kg can be administered intravenously over 2–5 min
Etyzem can also be used for the chronic control of supraventricular tachycardia. Doses higher than those used for heart rate control in atrial fibrillation are commonly needed to suppress supraventricular tachycardia. Doses as high as 4 mg/kg q.8 h PO may be required for this purpose in dogs without significant ventricular dysfunction. In general, the dose should be titrated, starting at a dose of 1 mg/kg q.8 h PO
Etyzem at doses ranging from 2–4 mg/kg q.8 h should probably not be administered to dogs that have moderate to severe myocardial failure or dogs with significant cardiac compromise
Common Side Effects
Etyzem can cause side effects. You should tell your doctor if the following symptoms are severe or do not go away:
- Dizziness or lightheadedness
- Slow heartbeat
- Nasal congestion
S >Both Etyzem and verapamil can cause hypotension, particularly in the IV forms. They both can cause flushing due to the vasodilator effects. They should be used with caution in conjunction with other drugs that have similar electrophysiologic effects, particularly β-blockers and digoxin. It should be noted that verapamil has several very important drug interactions. It cannot be used with dofetilide, as verapamil affects the renal clearance of that drug and can lead to severe QT prolongation. It also can interact with amiodarone and cause profound bradycardia. Calcium channel blockers have not been shown to be beneficial for patients with coronary artery disease or heart failure. Thus, when rate control medications are needed, β-blockers are preferable to calcium channel blockers in the CICU.
Serious Side Effects
Etyzem can cause serious side effects. You should call your doctor immediately if you experience:
- Swelling of the face, lips, tongue, eyes, hands, arms, feet, lower legs, or ankles
- Breathing or swallowing difficulties
- Yellowing of the skin or eyes (jaundice)
- Unusual bleeding or bruising
- Extreme fatigue
- Lack of energy
- Loss of appetite
- Pain in the upper right part of the stomach
- Increase in frequency or severity of chest pain
- Flu-like symptoms
ВїQuГ© otro uso se le da a este medicamento?
El Etyzem tambiГ©n se usa a veces para tratar ciertos tipos de arritmias (ritmos cardГacos anormales). Consulte a su mГ©dico sobre los riesgos de usar el Etyzem para tratar su affecciГіn.
A veces se receta este medicamento para otros usos; pГdales mГЎs informaciГіn a su mГ©dico o a su farmacГ©utico.
The therapeutic effects of Etyzem hydrochloride are believed to be related to its ability to inhibit the cellular influx of calcium ions during membrane depolarization of cardiac and vascular smooth muscle.
The clinical pharmacology of Etyzem when used to treat heart failure in cats is described earlier in the chapter ( p. 422 ).
Etyzem is also popular for decreasing ventricular rate in dogs with atrial fibrillation. In most canine patients, digoxin is administered first and the heart-rate response determined once a therapeutic serum concentration is achieved. If an adequate response is not achieved, Etyzem can be added to treatment protocol. Etyzem can also be used in dogs to treat supraventricular tachycardia.