Emistat tablets


  • Active Ingredient: Ondansetron
  • 8 mg, 4 mg
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What is Emistat?

The active ingredient of Emistat brand is ondansetron. Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting. The molecular formula is C18H19N3O•HCl•2H2O, representing a molecular weight of 365.9. Ondansetron HCl dihydrate is a white to off-white powder that is soluble in water and normal saline. Each 4 mg Ondansetron tablet, USP for oral administration contains Ondansetron hydrochloride dihydrate equivalent to 4 mg of Ondansetron. Each 8 mg Ondansetron tablet, USP for oral administration contains Ondansetron hydrochloride dihydrate equivalent to 8 mg of Ondansetron. Each tablet also contains the inactive ingredients croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinized starch, titanium dioxide, triacetin, and iron oxide yellow (8 mg tablet only). This product meets USP Dissolution Test 3.

Used for

Emistat is used to treat diseases such as: Alcohol Dependence, Gastroenteritis, Nausea/Vomiting, Nausea/Vomiting, Chemotherapy Induced, Nausea/Vomiting, Postoperative, Nausea/Vomiting, Radiation Induced, Obsessive Compulsive Disorder, Postanesthetic Shivering, Pruritus.

Side Effect

Possible side effects of Emistat include: headache; wheezing; large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs; slow or irregular breathing; decrease in the urine volume; increased blinking or spasms of the eyelid.

How to Buy Emistat tablets online?

To purchase Emistat online - just click on the "Buy Now" button from the top and follow along with our shop. Order and payment takes a couple of minutes, and all steps are evident. We don't take a medical prescription plus we have many procedures of payment. Considering all the details of rapid delivery and confidentiality, then you may read on the applicable pages on the links from the top menu.

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Allergy warning

Emistat can cause a severe allergic reaction. Symptoms can include:

  • flushing
  • trouble breathing
  • swelling of your throat or tongue
  • dizziness
  • coughing

If you develop these symptoms, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Drug forms and strengths

Generic: Emistat

  • Form: orally disintegrating tablet
  • Strengths: 4 mg, 8 mg

Brand: Zofran ODT

  • Form: orally disintegrating tablet
  • Strengths: 4 mg, 8 mg

Can I take Emistat while I am breastfeeding?

There have been no studies in humans looking at the use of Emistat during breastfeeding. Studies in animals suggest that Emistat enters breast milk, but the effects of Emistat on a breastfeeding infant are not known. If Emistat use is necessary, this is not a reason to stop breastfeeding but a different drug may be considered, especially while breastfeeding a newborn or preterm infant. Be sure to talk to your health care provider about all your choices for breastfeeding.

Zofran Interactions

Some drugs may affect the way Zofran works, and Emistat may affect other drugs you are taking.

It's very important to let your doctor know about all drugs you are taking, including over-the-counter medications as well as any herbs or supplements.

Drugs that are known to interact with Zofran and may cause problems include:

  • Apomorphine
  • Other serotonin 5-HT3 antagonists, including Lotronex, Anzemet, Kytril, and Aloxi
  • Some antibiotics, such as clarithromycin (Biaxin, in Prevpac) and erythromycin (E.E.S., Erythrocin)
  • Medications to treat irregular heartbeat, such as amiodarone (Cordarone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn) and others
  • Beta blockers, or drugs used to slow the heart rate, such as acebutolol (Sectral), atenolol (Tenormin), bisoprolol (Zebeta) and others
  • The pain medicine tramadol (Ultram, in Ultracet)
  • Some antiseizure medications, such as phenytoin (Dilantin)
  • Some antipsychotic medications, including thioridazine (Mellaril), haloperidol (Haldol), and mesoridazine (Serentil)
  • Some drugs used to treat depression, including venlafaxine (Effexor) and amitriptyline (Elavil)

Before taking Emistat

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking Emistat it is important that your doctor knows:

  • If you are pregnant or breastfeeding.
  • If you have any problems with the way your liver works.
  • If you have been told you have an irregular heartbeat.
  • If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
  • If you have ever had an allergic reaction to a medicine.

Adult Dose for Nausea/Vomiting


  • Prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy or moderately emetogenic cancer chemotherapy
  • Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic chemotherapy

Oral Emistat:

  • Highly Emetogenic Cancer Chemotherapy (HEC): Recommended dose: 24 mg orally 30 minutes before the start of single-day highly emetogenic cancer chemotherapy (including cisplatin doses of 50 mg/m2 or greater)
  • Moderately Emetogenic Cancer Chemotherapy (MEC): Recommended dose: 8 mg orally twice a day, with the first dose administered 30 minutes before the start of chemotherapy and the subsequent dose 8 hours later; then 8 mg orally 2 times a day (every 12 hours) for 1 to 2 days after the completion of chemotherapy

Parenteral Emistat:

  • Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy and subsequent doses given 4 and 8 hours after the first dose.
  • Maximum dose: 16 mg per dose


  • Multi-day, single-dose administration of 24 mg orally for highly emetogenic cancer chemotherapy has not been studied.
  • The injection formulation should be diluted prior to IV administration.

Drugs you should not use with Emistat

Do not take these drugs with Emistat. Doing so can cause dangerous effects in your body. Examples of these drugs include:

  • Apomorphine. Taking this drug with Emistat can cause your blood pressure to drop to unsafe levels. This can cause you to pass out.

Zofran S >

The most common side effects of Emistat are:

Serious side effects can occur. If you have any of these side effects, call your doctor right away:

  • Temporary blurred vision or loss of vision
  • Severe rash, hives, or a rash that causes blisters and peeling
  • Yellowing of skin or eyes or dark-colored urine
  • Seizure
  • Chest pain
  • Loss of consciousness
  • Swelling of face, lips, tongue, or other parts of the body
  • Difficulty breathing, swallowing, or talking

Emistat Hydrochlor >

Zofran . Research Triangle Park, NC: GlaxoSmithKline;2011 September.

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