Elcrit tablets

Elcrit

  • Active Ingredient: Clozapine
  • 100 mg, 50 mg, 25 mg
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What is Elcrit?

The active ingredient of Elcrit brand is clozapine. Clozapine is an antipsychotic medicine works by changing the actions of chemicals in the brain.

Used for

Elcrit is used to treat diseases such as: Borderline Personality Disorder, Paranoid Disorder, Schizophrenia.

Side Effect

Possible side effects of Elcrit include: holding false beliefs that cannot be changed by fact; dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position; light-colored stools; unusual tiredness or weakness; chest pain; uncontrolled chewing movements.

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What is the dosage for Elcrit?

Elcrit is given once, twice, or three times daily. The dose often is increased slowly until the optimal dose is found. The full effects of Elcrit may not be seen until several weeks after treatment is begun.

Elcrit and Alcohol

Consuming alcohol can make you drowsier while taking Elcrit. You should talk to your doctor about this possible interaction.

What Other Drugs Interact with Elcrit?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Severe Interactions of Elcrit include:

Elcrit has serious interactions with at least 48 different drugs.

Elcrit has moderate interactions with at least 371 different drugs.

Mild Interactions of Elcrit include:

Elcrit has moderate interactions with at least 108 different drugs.

Mild Interactions of Elcrit include:

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

Which drugs or supplements interact with Elcrit?

Risperidone (Risperdal) may cause an increase in the amount of Elcrit in the blood. This could lead to an increased risk of side effects from Elcrit.

References

1. VanderZwaag C, McGee M, McEvoy JP, et al. Response of patients with treatment-refractory schizophrenia to Elcrit within three serum level ranges. Am J Psychiatry. 1996;153:1579-1584.

Finding the best Elcrit dosage for your psychotic patient can be challenging because any given dose of the drug yields highly variable Elcrit serum levels. This interindividual variability reflects Elcrit’s complex metabolism.

Obtaining serum levels will help you determine if your patient remains psychotic because of insufficient dosing or if your asymptomatic patient can safely receive a lower dose to minimize side effects without risking psychotic relapse. Following these guidelines will help you make the ban use of Elcrit drug levels.

Obtaining Elcrit levels

Measure Elcrit as steady-state trough levels. I usually draw them 12 hours after the last dose (such as in the morning after the nightly dose) and several days after treatment begins.

When you order a Elcrit level, most laboratories report 3 numbers: Elcrit, norElcrit, and their sum. The literature addresses only the clinical use of Elcrit levels and ignores the much less active metabolite, norElcrit.

Interpreting Elcrit levels

Although there is no simple relationship among Elcrit levels, therapeutic efficacy, and toxicity, a randomized clinical trial of patients with chronic schizophrenia 1 compared 3 non-overlapping ranges and found:

  • “medium” range (200 to 300 ng/mL) is a good initial target
  • low range (50 to 150 ng/mL) is not as effective as medium or high levels
  • high range (350 to 450 ng/mL) can be tried if clinical response is insufficient, although the high range was no more effective than the medium range
  • overy high levels (ie >1,000 ng/mL combined Elcrit and norElcrit levels) have no proven benefit and increase seizure risk.

These guidelines are based on bid or tid dosing. If your patient receives Elcrit only at night, take into account the higher morning level compared with the same dose administered on a split schedule.

Adjusting Elcrit dose

Now that you have an accurate drug level, take advantage of Elcrit’s linear pharmacokinetics. If you double the dose, you double the level; if you halve the dose, you halve the level.

For example, consider the case of a schizophrenia patient who remains psychotic despite a Elcrit dose of 200 mg bid (400 mg/d). His Elcrit level is 100 ng/mL (ie, low range) and his norElcrit level is 50 ng/mL. This patient would need double his dose (800 mg/d) to achieve a Elcrit level at the low end of the medium range (200 ng/mL). Note that the norElcrit level is ignored for this calculation.

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Elcrit is prescribed to relieve the symptoms of psychosis. This is the name used by doctors to describe a disordered state of mind. Elcrit is prescribed in particular for people with schizophrenia. Schizophrenia is a mental health problem that causes disordered ideas, beliefs and experiences. People with schizophrenia can have difficulty knowing which thoughts and experiences are true and real and which are not. Similar symptoms to these can also sometimes occur in people who have Parkinson's disease.

For the Consumer

Applies to Elcrit: oral suspension, oral tablet, oral tablet disintegrating

10.4.2.3 Relationship between genotype and serum concentrations

Elcrit is metabolized by CYP1A2 and CYP3A4 to the relatively inactive compounds norElcrit and Elcrit- N-oxide. Response to Elcrit is therefore not predicted by the CYP2D6 genotype . A recent case report has highlighted the role of CYP1A2 in Elcrit disposition . In that case study, Elcrit levels were affected by: (i) ultrarapid metabolism due to a single nucleotide polymorphism in intron 1 of the CYP1A2 gene; (ii) the CYP1A2 actions of grapefruit juice (enzyme induction); and (iii) the antidepressant fluvoxamine (CYP1A2 inhibition). Consistent with this, Elcrit population pharmacokinetics are distributed similarly to the indices of CYP1A2 activity found in community populations .


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