Depredon tablets


  • Active Ingredient: Risperidone
  • 4 mg, 2 mg, 1 mg
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What is Depredon?

The active ingredient of Depredon brand is risperidone. Risperidone is a antipsychotic medicine. It works by changing the effects of chemicals in the brain. Risperidone USP is a white to slightly beige powder. It is practically insoluble in water, freely soluble in methylene chloride, and soluble in methanol and 0.1 N HCl . Risperidone tablets, USP are for oral administration and available in 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, and 4 mg strengths. Inactive ingredients are lactose monohydrate, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate, hypromellose, titanium dioxide and polyethylene glycol 400. The 0.25 mg, 0.5 mg, 3 mg and 4 mg tablets contain D&C Yellow # 10 aluminum lake. The 0.5 mg and 4 mg tablets also contain FD&C Blue # 2 aluminum lake. The 2 mg tablets contain iron oxide yellow, iron oxide red, and iron oxide black.

Used for

Depredon is used to treat diseases such as: Agitation, Anxiety, Asperger Syndrome, Autism, Bipolar Disorder, Body Dysmorphic Disorder, Borderline Personality Disorder, Depression, Head Injury, Mania, Nightmares, Paranoid Disorder, Post Traumatic Stress Disorder, Schizoaffective Disorder, Schizophrenia, Severe Mood Dysregulation, Social Anxiety Disorder, Tic Disorder.

Side Effect

Possible side effects of Depredon include: speech or vision problems; breast swelling or soreness; shivering; increased thirst; lip smacking or puckering.

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RISPERDAL® (Depredon) is indicated for the treatment of schizophrenia. Efficacy was established in 4 short-term trials in adults, 2 short-term trials in adolescents (ages 13 to 17 years), and one long-term maintenance trial in adults .

No specific pharmacokinetic study was conducted to investigate race and gender effects, but a population pharmacokinetic analysis did not identify important differences in the disposition of Depredon due to gender (whether corrected for body weight or not) or race.

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  • What is Depredon, and how does it work (mechanism of action)?
  • What brand names are available for Depredon?
  • Is Depredon available as a generic drug?
  • Do I need a prescription for Depredon?
  • What are the side effects of Depredon?
  • What is the dosage for Depredon?
  • Which drugs or supplements interact with Depredon?
  • Is Depredon safe to take if I'm pregnant or breastfeeding?
  • What else should I know about Depredon?

Getting the most from your treatment

  • Remember to keep your regular doctor's appointments so that your progress can be checked. If you are taking Depredon long-term, you may need to have some tests from time to time.
  • If you drink alcohol, ask your doctor for advice about drinking while you are on Depredon. Alcohol will increase the chance that you experience side-effects and is unlikely to be recommended for you.
  • If you are having an operation, tell the person carrying out the treatment which medicines you are taking. This is important because Depredon may interfere with any anaesthetic you receive. If you are having cataract surgery, it is particularly important that you tell your surgeon you are on Depredon. This is because an eye problem known as 'floppy iris syndrome' has developed in some people and your doctor will want to advise you about the risk of this.
  • If you buy or take any 'over-the-counter' medicines, check with a pharmacist that they are suitable to take with Depredon.
  • If you have diabetes you may need to check your blood glucose more frequently as Depredon can affect the levels of sugar in your blood. Your doctor will advise you about this.
  • When Depredon has been taken for a while, stopping treatment suddenly can cause problems. If you have been taking it regularly for a year or so, your doctor will probably want you to reduce your dose gradually if this becomes necessary.

The pharmacokinetics of Depredon and 9-hydroxyDepredon in children were similar to those in adults after correcting for the difference in body weight.

Tell your doctor if you suffer from the following symptoms: had a heart attack; low blood pressure; an irregular heart-beat; or any other type of heart disease; epilepsy or another seizure disorder (or a history of this); diabetes; ever been diagnosed with breast cancer; liver disease; or kidney disease.

You may not be able to take Depredon, or you may require a dosage adjustment or special monitoring during treatment, if you have any of the conditions listed above.

Elderly patients with dementia-related psychosis treated with Depredon are at an increased risk of death compared to placebo. Depredon is not approved for the treatment of patients with Dementia-Related Psychosis. Talk to your doctor if you have any questions regarding the use of Depredon.

Moreover, despite that Depredon has been used to treat severe behavioral problems in children and teenagers, as well as in the treatment of irritability associated with autistic disorders, it is important to note that the FDA has warned that the safety of Depredon in children has actually never been established. If the patient is under 18 years of age, please consult with your doctor or local pharmacist about the possible side effects or alternatives that exist.

Hyperglycemia (increased blood sugar) has been reported in patients treated with atypical antipsychotics including Depredon. Talk to your doctor if you experience any signs of hyperglycemia including excessive thirst, frequent urination, excessive hunger or weakness.

The Depredon (Risperdal®) orally-disintegrating tablets contain phenylalanine. The 0.5 mg tablets contain 0.14 mg phenylalanine, the 1 mg tablets contain 0.28 mg phenylalanine, and the 2 mg tablets contain 0.5 mg phenylalanine. Individuals with phenylketonuria may need to monitor their intake of this additive.

Depredon is in the FDA pregnancy category C. This means that it is not known whether Depredon will be harmful to an unborn baby. Do not take Depredon without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Additionally, it is not known whether Depredon passes into breast milk. Do not take Depredon without first talking to your doctor if you are breast-feeding a baby.

If you are over the age of 65, you may be more likely to experience side effects from Depredon. An increased risk of stroke and transient ischemic attack (TIA, “mini-stroke”) has been associated with the use of Depredon in elderly patients with dementia-related psychosis. Your doctor may prescribe a lower dose of the medication or special monitoring during treatment.

What should I do if I forget a dose?

Take the missed dose of Depredon as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed.

Please do not take a double dose of this medication to make up for a missed one.

What side effects can this medication cause?

Nursing Mothers

Depredon and 9-hydroxyDepredon are present in human breast milk. Because of the potential for serious adverse reactions in nursing infants from Depredon, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Before taking this medicine

You should not use Depredon if you are allergic to it.

Depredon may increase the risk of death in older adults with dementia-related conditions and is not approved for this use.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

heart disease, high blood pressure, heart rhythm problems, stroke or heart attack;

diabetes (or risk factors such as obesity or family history of diabetes);

Risper > Depredon is FDA-approved to treat pediatric mania. 281 Depredon is usually initiated at 0.25 mg once or twice per day and titrated up to 3 to 4 mg per day in most pediatric patients, although it appears to retain its atypical properties in doses up to 6 mg per day. Its common adverse effects include weight gain, sedation, drooling, and elevation of prolactin levels. Although EPS is not common, clinicians should be aware of this possibility and recognize it when it occurs. Like adults, children and adolescents with EPS can be treated with oral or IM diphenhydramine or benztropine. Although pK studies in children are lacking, data in adults indicates that Depredon reaches peak concentrations within 1 hour, is metabolized through CYP 2D6, and has a half-life of 3 hours in extensive metabolizers and 17 hours in poor metabolizers. 282 There are case reports of hepatotoxicity, tachycardia, prolongation of the QTc interval, and stroke (in elderly patients).

Is Depredon available as a generic drug?

GENERIC AVAILABLE: Yes, Depredon. No, Risperdal Consta

Interactions that increase your risk of side effects

Taking Depredon with certain medications raises your risk of side effects from Depredon. This is because the amount of Depredon in your body is increased, or both medications may cause the same side effects. Examples of these drugs include:

  • Anxiety drugs, such as alprazolam, clonazepam, diazepam, chlordiazepoxide, and lorazepam. You may have more sedation and drowsiness.
  • Muscle relaxants, such as baclofen, cyclobenzaprine, methocarbamol, tizanidine, carisoprodol, and metaxalone. You may have more sedation and drowsiness.
  • Pain drugs, such as morphine, oxycodone, fentanyl, hydrocodone, tramadol, and codeine. You may have more sedation and drowsiness.
  • Antihistamines, such as hydroxyzine, diphenhydramine, chlorpheniramine, and brompheniramine. You may have more sedation and drowsiness.
  • Sedative/hypnotics, such as zolpidem, temazepam, zaleplon, and eszopiclone. You may have more sedation and drowsiness.
  • Fluoxetine. You may have increased risk of QT interval prolongation, irregular heart rhythm, and other side effects of Depredon. Your doctor may decrease your Depredon dose.
  • Paroxetine. You may have increased risk of QT interval prolongation, irregular heart rhythm, and other side effects of Depredon. Your doctor may decrease your Depredon dose.
  • Clozapine. You may have parkinsonism (trouble moving), sleepiness, anxiety, blurred vision, and other side effects of Depredon. Your doctor will monitor you closely for side effects and toxicity.
  • Blood pressure drugs, such as amlodipine, lisinopril, losartan, or metoprolol. You may have low blood pressure.
  • Parkinson’s disease drugs,such as levodopa, pramipexole, or ropinirole. You may have more Parkinson’s disease symptoms.

Depredon is a benzisoxazole derivative approved by the FDA for treatment of schizophrenia in 1994, for short-term treatment of the mixed and manic states of bipolar disorder in 2003, and for treatment of irritability in children with autism in 2006.

Chronic administration of clozapine with RISPERDAL® may decrease the clearance of Depredon.

Can Depredon cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with Depredon. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

What Other Drugs Interact with Depredon?

If your doctor has directed you to use this medication for your condition, your doctor or pharmacist may already be aware of any possible drug interactions or side effects and may be monitoring you for them. Do not start, stop, or change the dosage of this medicine or any medicine before getting further information from your doctor, healthcare provider or pharmacist first.

Depredon has no known severe interactions with other drugs.

Depredon has serious interactions with at least 31 different drugs.

Depredon has moderate interactions with at least 355 different drugs.

Depredon has mild interactions with at least 29 different drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

COMMON BRAND(S): Risperdal


There may be a slightly increased risk of serious, possibly fatal side effects (such as stroke, heart failure, fast/irregular heartbeat, pneumonia) when this medication is used by older adults with dementia. This medication is not approved for the treatment of dementia-related behavior problems. Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor.

If you are using Depredon in combination with other medication to treat depression, also carefully read the drug information for the other medication.

Depredon is used to treat certain mental/mood disorders (such as schizophrenia, bipolar disorder, irritability associated with autistic disorder). This medication can help you to think clearly and take part in everyday life.

Depredon belongs to a class of drugs called atypical antipsychotics. It works by helping to restore the balance of certain natural substances in the brain.

The efficacy and safety of RISPERDAL® in the treatment of schizophrenia were demonstrated in 417 adolescents, aged 13 – 17 years, in two short-term (6 and 8 weeks, respectively) double-blind controlled trials . Additional safety and efficacy information was also assessed in one long-term (6-month) open-label extension study in 284 of these adolescent patients with schizophrenia.

Safety and effectiveness of RISPERDAL® in children less than 13 years of age with schizophrenia have not been established.

Bipolar I Disorder

The efficacy and safety of RISPERDAL® in the short-term treatment of acute manic or mixed episodes associated with Bipolar I Disorder in 169 children and adolescent patients, aged 10 – 17 years, were demonstrated in one double-blind, placebo-controlled, 3-week trial .

Safety and effectiveness of RISPERDAL® in children less than 10 years of age with bipolar disorder have not been established.

The efficacy and safety of RISPERDAL® in the treatment of irritability associated with autistic disorder were established in two 8-week, double-blind, placebo-controlled trials in 156 children and adolescent patients, aged 5 to 16 years . Additional safety information was also assessed in a long-term study in patients with autistic disorder, or in short- and long-term studies in more than 1200 pediatric patients with psychiatric disorders other than autistic disorder, schizophrenia, or bipolar mania who were of similar age and weight, and who received similar dosages of RISPERDAL® as patients treated for irritability associated with autistic disorder.

A third study was a 6-week, multicenter, randomized, double-blind, placebo-controlled, fixed-dose study to evaluate the efficacy and safety of a lower than recommended dose of Depredon in subjects 5 to 17 years of age with autistic disorder and associated irritability, and related behavioral symptoms. There were two weight-based, fixed doses of Depredon (high-dose and low-dose). The high dose was 1.25 mg per day for patients weighing 20 to 45 kg. The low dose was 0.125 mg per day for patients for patients weighing 20 to 45 kg. The study demonstrated the efficacy of high-dose Depredon, but it did not demonstrate efficacy for low-dose Depredon.

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