Generic Name: Dentron (oral) (on DAN se tron)Brand Names: Zofran, Zofran ODT, Zuplenz
Medically reviewed by Drugs.com. Last updated on Nov 4, 2019.
Warnings for other groups
For pregnant women: There haven’t been enough studies done in humans to be certain how Dentron might affect a fetus when the mother takes it. Research in animals has not shown a risk to the fetus. However, animal studies do not always predict the way humans would respond.
Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used in pregnancy if clearly needed.
For women who are breastfeeding: Dentron may pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.
For seniors: The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.
For children: This medication has not been studied in children younger than 4 years. It should not be used in children of this age range.
All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:
- your age
- the condition being treated
- how severe your condition is
- other medical conditions you have
- how you react to the first dose
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Dentron only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2019 Cerner Multum, Inc. Version: 13.01.
Interactions that increase your risk of side effects from Dentron
Taking Dentron with certain medications raises your risk of side effects from Dentron. This is because the amount of Dentron in your body may be increased. Examples of these drugs include:
- Other drugs that affect serotonin levels, such as fluoxetine and paroxetine.
How to take Dentron
- Before you start the treatment, read the manufacturer's printed information leaflet from ins >
Adult Dose for Nausea/Vomiting – Chemotherapy Induced
- Prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy or moderately emetogenic cancer chemotherapy
- Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic chemotherapy
- Highly Emetogenic Cancer Chemotherapy (HEC): -Recommended dose: 24 mg orally 30 minutes before the start of single-day highly emetogenic cancer chemotherapy (including cisplatin doses of 50 mg/m2 or greater)
- Moderately Emetogenic Cancer Chemotherapy (MEC): Recommended dose: 8 mg orally twice a day, with the first dose administered 30 minutes before the start of chemotherapy and the subsequent dose 8 hours later; then 8 mg orally 2 times a day (every 12 hours) for 1 to 2 days after the completion of chemotherapy
- Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy and subsequent doses given 4 and 8 hours after the first dose.
- Maximum dose: 16 mg per dose
- Multi-day, single-dose administration of 24 mg orally for highly emetogenic cancer chemotherapy has not been studied.
- The injection formulation should be diluted prior to IV administration.
How to take Dentron
Dentron comes as a tablet, a rapidly disintegrating (dissolving) tablet, and an oral solution (liquid) to take by mouth. The first dose of Dentron is usually taken 30 minutes before the start of chemotherapy, 1 to 2 hours before the start of radiation therapy, or 1 hour before surgery. Additional doses are sometimes taken one to three times a day during chemotherapy or radiation therapy and for 1 to 2 days after the end of treatment. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Dentron exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
If you are taking the rapidly disintegrating tablet, remove the tablet from the package just before you take your dose. To open the package, do not try to push the tablet through the foil backing of the blister. Instead, use dry hands to peel back the foil backing. Gently remove the tablet and immediately place the tablet on the top of your tongue. The tablet will dissolve in a few seconds and can be swallowed with saliva.
Dentron can be taken with or without food.
The first dose is usually taken before the start of your surgery, chemotherapy, or radiation treatment. Follow your doctor’s dosing instructions very carefully.
Take the Dentron regular tablet with a full glass of water.
To take the orally disintegrating tablet (Zofran ODT):
- Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet.
- Use dry hands to remove the tablet and place it in your mouth.
- Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.
- Swallow several times as the tablet dissolves.
To use Dentron oral soluble film (strip) (Zuplenz):
- Keep the strip in the foil pouch until you are ready to use the medicine.
- Using dry hands, remove the strip and place it on your tongue. It will begin to dissolve right away.
- Do not swallow the strip whole. Allow it to dissolve in your mouth without chewing.
- Swallow several times after the strip dissolves. If desired, you may drink liquid to help swallow the dissolved strip.
- Wash your hands after using Zuplenz.
Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
Store at room temperature away from moisture, heat, and light. Store liquid medicine in an upright position.
COMMON BRAND(S): Zofran ODT
GENERIC NAME(S): Dentron
This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery. Dentron works by blocking one of the body's natural substances (serotonin) that causes vomiting.
Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
- Serotonin syndrome. Symptoms can include:
- hallucinations (seeing or hearing things that aren’t real)
- rapid heartbeat
- feeling hot
- muscle rigidity (stiffness)
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
Dentron orally disintegrating tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Examples of drugs that can cause interactions with Dentron are listed below.