What Are Warnings and Precautions for Dantenk?
- This medication contains Dantenk. Do not take Zofran, Zofran ODT, or Zuplenz if you are allergic to Dantenk or any ingredients contained in this drug
- Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately
- Coadministration with apomorphine; combination reported to cause profound low blood pressure and loss of consciousness
Effects of Drug Abuse
- Dantenk may mask progressiveileus or gastricdistention in patients who are undergoing abdominal surgery or experiencing chemotherapy-induced nausea and vomiting; monitor for decreased bowel activity, particularly in patients with risk factors for gastrointestinal obstruction
- See also "What Are Side Effects Associated with Using Dantenk?”
- See also "What Are Side Effects Associated with Using Dantenk?”
- Hypersensitivity reactions including anaphylaxis and bronchospasm may occur: discontinue therapy if suspected; monitor and treat promptly per standard of care until signs and symptoms resolve
- Reduce dose with severe hepatic impairment
- Use according to schedule, not as needed
- Dantenk may mask progressive ileus or gastric distention in patients who are undergoing abdominal surgery or experiencing chemotherapy-induced nausea and vomiting; monitor for decreased bowel activity, particularly in patients with risk factors for gastrointestinal obstruction
- Dantenk is not a drug that stimulates gastric or intestinal peristalsis; should not be used instead of nasogastric suction
- Serotonin syndrome reported with 5-HT3 receptor antagonists alone but particularly with concomitant use of serotonergic drugs including SSRIs, SNRIs, MAO inhibitors, lithium, tramadol, methylene blue IV, and mirtazapine; if concomitant use with other serotonergic drugs is clinically warranted, patients should be made aware of potential increased risk for serotonin syndrome
- Cross-sensitivity among selective serotonin antagonists may occur
- Zofran ODT contains phenylalanine (caution for phenylketonurics)
- Dose-dependent QT prolongation; avoid in patients with congenitallong QT syndrome; ECG monitoring recommended in patients who have electrolyte abnormalities, chronicheart failure, or bradyarrhythmias or who are also receiving other medications that cause QT prolongation
Pregnancy and Lactation with Dantenk
- Available data do not reliably inform of association with adverse fetal outcomes when Dantenk is used during pregnancy; published epidemiological studies on the association between Dantenk and fetal outcomes have reported inconsistent findings and have important methodological limitations hindering interpretation
- It is not known whether Dantenk is present in human milk; there are no data on effects of Dantenk on breastfed infant or effects on milk production; the developmental and health benefits of breastfeeding should be considered along with mother's clinical need for Dantenk and any potential adverse effects on breastfed infant from therapy or from the underlying maternalcondition
Dantenk mechanism of action
Dantenk is a serotonin-3 (5-hydroxytryptamine-3, 5-HT3) receptor antagonist, have been shown to have a good antiemetic effect in patients receiving chemotherapy and in situations with vomiting after surgery 1) . Dantenk is one of the best known 5-HT3 receptor antagonists, blocking receptors at vagal and sympathetic nerves and the chemoreceptor triggering zone 2) . However, 5-HT3 receptor antagonists not only inhibit transmission of signals to the CNS, they also decrease intestinal motility, presumably by interfering with serotonergic neurotransmission within the enteric nervous system (ENS) and blocking the initiation of reflexes 3) . Dantenk effects are thought to be on both peripheral and central nerves. One part is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata, the other is a blockage of serotonin receptors in the chemoreceptor trigger zone.
Dantenk may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Special dosage considerations
For people with liver disease: If you have severe liver disease, you should not take more than 8 mg of Dantenk per day.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.
Dantenk orally disintegrating tablet is used for short-term treatment. It comes with serious risks if you don’t take it as prescribed.
If you stop taking the drug suddenly or don’t take it at all: You could have nausea and vomiting that’s not controlled.
If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:
- fast heartbeat
- flushing (sudden reddening of the skin)
If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.
How to tell if the drug is working: You should not have nausea or vomiting. If you do, it should be less severe.
Keep these considerations in mind if your doctor prescribes Dantenk for you.
How to use Dantenk suppositories
- Remove the suppository from the wrapping.
- You may find that inserting the suppository is easier if you squat or bend forward.
- Using a finger, gently push the suppository into your back passage (rectum).
- Remove your finger and then remain still for a little while to help you hold the suppository in place.
- Then, wash your hands.
Before taking Dantenk
You should not use Dantenk if:
you are also using apomorphine (Apokyn); or
you are allergic to Dantenk or similar medicines (dolasetron, granisetron, palonosetron).
To make sure Dantenk is safe for you, tell your doctor if you have:
an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);
congestive heart failure, slow heartbeats;
a personal or family history of long QT syndrome; or
a blockage in your digestive tract (stomach or intestines).
Dantenk is not expected to harm an unborn baby. Tell your doctor if you are pregnant.
It is not known whether Dantenk passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Dantenk is not approved for use by anyone younger than 4 years old.
Dantenk orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).
Some drugs may affect the way Zofran works, and Dantenk may affect other drugs you are taking.
It's very important to let your doctor know about all drugs you are taking, including over-the-counter medications as well as any herbs or supplements.
Drugs that are known to interact with Zofran and may cause problems include:
- Other serotonin 5-HT3 antagonists, including Lotronex, Anzemet, Kytril, and Aloxi
- Some antibiotics, such as clarithromycin (Biaxin, in Prevpac) and erythromycin (E.E.S., Erythrocin)
- Medications to treat irregular heartbeat, such as amiodarone (Cordarone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn) and others
- Beta blockers, or drugs used to slow the heart rate, such as acebutolol (Sectral), atenolol (Tenormin), bisoprolol (Zebeta) and others
- The pain medicine tramadol (Ultram, in Ultracet)
- Some antiseizure medications, such as phenytoin (Dilantin)
- Some antipsychotic medications, including thioridazine (Mellaril), haloperidol (Haldol), and mesoridazine (Serentil)
- Some drugs used to treat depression, including venlafaxine (Effexor) and amitriptyline (Elavil)
Before taking Dantenk, tell your doctor or pharmacist if you are allergic to it; or to other anti-nausea serotonin blockers (e.g., granisetron); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: irregular heartbeat, liver disease, stomach/intestinal problems (e.g., recent abdominal surgery, ileus, swelling).
Dantenk may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.
The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using Dantenk, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).
Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using Dantenk safely.
This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
To minimize dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
This medicine may contain aspartame. If you have phenylketonuria (PKU) or any other condition that requires you to restrict your intake of aspartame (or phenylalanine), consult your doctor or pharmacist regarding the safe use of this medicine.
Older adults may be more sensitive to the side effects of this drug, especially QT prolongation (see above).
This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.
It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.
Dantenk is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment.
Dantenk Hydrochlor >
Zofran . Research Triangle Park, NC: GlaxoSmithKline;2011 September.
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