Cruzafen tablets


  • Active Ingredient: Ondansetron
  • 8 mg, 4 mg
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What is Cruzafen?

The active ingredient of Cruzafen brand is ondansetron. Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting. The molecular formula is C18H19N3O•HCl•2H2O, representing a molecular weight of 365.9. Ondansetron HCl dihydrate is a white to off-white powder that is soluble in water and normal saline. Each 4 mg Ondansetron tablet, USP for oral administration contains Ondansetron hydrochloride dihydrate equivalent to 4 mg of Ondansetron. Each 8 mg Ondansetron tablet, USP for oral administration contains Ondansetron hydrochloride dihydrate equivalent to 8 mg of Ondansetron. Each tablet also contains the inactive ingredients croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinized starch, titanium dioxide, triacetin, and iron oxide yellow (8 mg tablet only). This product meets USP Dissolution Test 3.

Used for

Cruzafen is used to treat diseases such as: Alcohol Dependence, Gastroenteritis, Nausea/Vomiting, Nausea/Vomiting, Chemotherapy Induced, Nausea/Vomiting, Postoperative, Nausea/Vomiting, Radiation Induced, Obsessive Compulsive Disorder, Postanesthetic Shivering, Pruritus.

Side Effect

Possible side effects of Cruzafen include: dry mouth; difficulty having a bowel movement (stool); hiccups; redness of the skin; chest pain or discomfort; difficulty with breathing.

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  • You can take Cruzafen with or without food.
  • Take this drug at the time(s) recommended by your doctor.
  • Do not cut or crush the orally disintegrating tablets.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Cruzafen in the elderly.

What is Cruzafen used for? Healthcare providers may prescribe Cruzafen to people who may have nausea and vomiting after undergoing chemotherapy, radiation treatment, or surgery. Cruzafen is designed to prevent nausea and vomiting from occurring, rather than treating it once it has begun. Cruzafen does have some off-label uses, such as to help prevent morning sickness during pregnancy.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Cruzafen only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2019 Cerner Multum, Inc. Version: 13.01.

Interactions that increase your risk of side effects from Cruzafen

Taking Cruzafen with certain medications raises your risk of side effects from Cruzafen. This is because the amount of Cruzafen in your body may be increased. Examples of these drugs include:

  • Other drugs that affect serotonin levels, such as fluoxetine and paroxetine.

Cruzafen (Zofran) is a prescription medication that can be used for prevention or treatment of nausea and vomiting. Zofran is often prescribed every 8 hours as needed for a maximum of 24 mg per day.

Why is this medication prescribed?

Cruzafen is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery. Cruzafen is in a class of medications called serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting.

How to use Cruzafen ODT

This medication is dissolved on top of the tongue. It is not meant to be chewed or swallowed like other tablet forms.

Dry your hands before using this medication. This medication may come in a bottle or a blister pack. If using the blister pack, peel back the foil on the blister pack to remove a tablet. Do not push the tablet through the foil. Immediately after removing the tablet, place it on the tongue. Allow it to dissolve completely, then swallow it with saliva. You do not need to take this product with water. Doing so may increase your chance of getting a headache.

To prevent nausea from chemotherapy, take this medication usually within 30 minutes before treatment begins. To prevent nausea from radiation treatment, take this medication 1 to 2 hours before the start of your treatment. To prevent nausea after surgery, take Cruzafen 1 hour before the start of surgery. This medication may be taken with or without food. However, your doctor may tell you not to eat before chemotherapy, radiation, or surgery.

Take any other doses as directed by your doctor. Cruzafen may be taken up to 3 times a day for 1 to 2 days after your chemotherapy or radiation treatment is finished. If you are taking this medication on a prescribed schedule, take it regularly in order to get the most benefit from it. To help you remember, take it at the same times each day.

Dosage is based on your medical condition and response to therapy. The dosage for children may also be based on age and weight. In patients with severe liver problems, the usual maximum dose is 8 milligrams in 24 hours. Take this medication exactly as directed. Do not take more medication or take it more often than prescribed. Ask your doctor or pharmacist if you have questions.

Inform your doctor if your condition does not improve or if it worsens.

Cruzafen special precautions

Before taking Cruzafen:

  • tell your doctor and pharmacist if you are allergic to Cruzafen, alosetron (Lotronex), dolasetron (Anzemet), granisetron (Kytril), palonosetron (Aloxi, in Akynzeo), any other medications, or any of the ingredients in Cruzafen tablets or liqu >Cruzafen while pregnant

Cruzafen has also been prescribed during pregnancy to reduce symptoms of nausea and vomiting in pregnancy. Nausea and vomiting in pregnancy is also referred to as “morning sickness”. Cruzafen is sold under the brand name Zofran ® .

Nausea and vomiting in pregnancy or “morning sickness” is the most common medical condition in pregnancy. It affects 50-80% of pregnant women. Nausea and vomiting in pregnancy symptoms can range from mild to severe. The symptoms can happen at any time during the day or at night. Symptoms can include nausea, dry heaves, retching and/or vomiting. Nausea and vomiting in pregnancy usually begins between 4-9 weeks of pregnancy, and peaks between 7-12 weeks. In most women, symptoms go away between 12-16 weeks of pregnancy. Up to 15% of women will continue to have symptoms up to 20 weeks of pregnancy or until delivery.

The most severe form of nausea and vomiting in pregnancy is known as hyperemesis gravidarum, which affects up to 3% of pregnant women. Hyperemesis gravidarum is when there is severe nausea and constant vomiting that causes weight loss and dehydration (not getting enough water). Women with hyperemesis gravidarum can require hospitalization.

Whether symptoms of nausea and vomiting in pregnancy are mild, moderate or severe, it can have a major impact on a woman’s quality of life. If nausea and vomiting in pregnancy is affecting your ability to eat, sleep and perform your daily activities, speak with your healthcare provider. If the symptoms of nausea and vomiting in pregnancy first start at the 10th week of pregnancy or later they may be due to other causes and should be discussed with your healthcare provider.

Eating small meals often, drinking plenty of clear fluids, and avoiding triggers (such as odors, heat, and spicy or high fat foods) can help control nausea and vomiting during pregnancy.

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