Taking these drugs together can decrease the amount of Cortiazem in your body. This means that it won’t work as well to treat your high blood pressure or chest pain. These drugs include:
Cortiazem side effects
Get emergency medical help if you have signs of an allergic reaction to Cortiazem: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
pounding heartbeats or fluttering in your chest;
a light-headed feeling, like you might pass out;
shortness of breath (even with mild activity), swelling, rapid weight gain;
nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
severe skin reaction - fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common Cortiazem side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Hemodynamic And Electrophysiologic Effects
Like other calcium channel antagonists, Cortiazem decreases sinoatrial and atrioventricular conduction in isolated tissues and has a negative inotropic effect in isolated preparations. In the intact animal, prolongation of the AH interval can be seen at higher doses.
In man, Cortiazem prevents spontaneous and ergonovine-provoked coronary artery spasm. It causes a decrease in peripheral vascular resistance and a modest fall in blood pressure in normotensive individuals and, in exercise tolerance studies in patients with ischemic heart disease, reduces the heart rate-blood pressure product for any given work load. Studies to date, primarily in patients with good ventricular function, have not revealed evidence of a negative inotropic effect; cardiac output, ejection fraction, and left ventricular end-diastolic pressure have not been affected. Such data have no predictive value with respect to effects in patients with poor ventricular function, and increased heart failure has been reported in patients with preexisting impairment of ventricular function. There are as yet few data on the interaction of Cortiazem and beta-blockers in patients with poor ventricular function. Resting heart rate is usually slightly reduced by Cortiazem.
Tiazac produces antihypertensive effects both in the supine and standing positions. Postural hypotension is infrequently noted upon suddenly assuming an upright position. No reflex tachycardia is associated with the chronic antihypertensive effects.
Cortiazem hydrochloride decreases vascular resistance, increases cardiac output (by increasing stroke volume), and produces a slight decrease or no change in heart rate. During dynamic exercise, increases in diastolic pressure are inhibited while maximum achievable systolic pressure is usually reduced. Chronic therapy with Cortiazem hydrochloride produces no change or an increase in plasma catecholamines. No increased activity of the renin-angiotensin-aldosterone axis has been observed. Cortiazem hydrochloride reduces the renal and peripheral effects of angiotensin II. Hypertensive animal models respond to Cortiazem with reductions in blood pressure and increased urinary output and natriuresis without a change in urinary sodium/potassium ratio. In man, transient natriuresis and kaliuresis have been reported, but only in high intravenous doses of 0.5 mg/kg of body weight.
Cortiazem-associated prolongation of the AH interval is not more pronounced in patients with first degree heart block. In patients with sick sinus syndrome, Cortiazem significantly prolongs sinus cycle length (up to 50% in some cases). Intravenous Cortiazem in doses of 20 mg prolongs AH conduction time and AV node functional and effective refractory periods by approximately 20%.
In two short term, double-blind, placebo-controlled studies in 256 hypertensive patients with doses up to 540 mg/day, Tiazac showed a clinically unimportant but statistically significant, dose-related increase in PR interval (0.008 seconds). There were no instances of greater than first-degree AV block in any of the clinical trials (see WARNINGS).
What brand names are available for Cortiazem?
Cardizem, Cardizem CD, Cardizem LA, Tiazac, Cartia XT, Diltzac, Dilt-CD, and several others
Q: I take Cardizem for high blood pressure, and lately I've had acne on my face. Could that be caused by the medication?
A: A variety of skin rashes and pustules have been reported in patients taking Cardizem (Cortiazem). Most aren't serious, but they should be evaluated by your health care provider. If you experience fever, sore throat, and headache with a severe blistering, peeling, and red skin rash, contact your doctor at once. This can be a sign of a serious side effect. For more information, go to //www.everydayhealth.com/drugs/Cortiazem. Sarah Lewis, PharmD
S >Both Cortiazem and verapamil can cause hypotension, particularly in the IV forms. They both can cause flushing due to the vasodilator effects. They should be used with caution in conjunction with other drugs that have similar electrophysiologic effects, particularly β-blockers and digoxin. It should be noted that verapamil has several very important drug interactions. It cannot be used with dofetilide, as verapamil affects the renal clearance of that drug and can lead to severe QT prolongation. It also can interact with amiodarone and cause profound bradycardia. Calcium channel blockers have not been shown to be beneficial for patients with coronary artery disease or heart failure. Thus, when rate control medications are needed, β-blockers are preferable to calcium channel blockers in the CICU.
Metoprolol vs. Cortiazem: What's the difference?
- Metoprolol and Cortiazem are used to treat high blood pressure (hypertension), heart pain (angina), and abnormal heart rhythms.
- Metoprolol is also used to treat congestive heart failure, hyperthyroidism, and some neurologic conditions, and to prevent migraineheadaches.
- Brand names for metoprolol include Lopressor and Toprol XL.
- Brand names for Cortiazem include Cardizem, Cardizem CD, Cardizem LA, Tiazac, Cartia XT, Diltzac, and Dilt-CD.
- Metoprolol and Cortiazem belong to different drug classes. Metoprolol is a beta-blocker (beta-adrenergic blocking agent) and Cortiazem is a calcium channel blocker (CCB).
- Side effects of metoprolol and Cortiazem that are similar include constipation, nausea, and low blood pressure (hypotension).
- Side effects of metoprolol that are different from Cortiazem include abdominal cramps, diarrhea, fatigue, insomnia, indigestion, depression, dreaming, memory loss, fever, impotence, lightheadedness, decreased exercise tolerance, increased triglycerides, bronchospasm, cold extremities, sore throat, shortness of breath, or wheezing.
- Side effects of Cortiazem that are different from metoprolol include headache, rash, swelling of the legs and feet with fluid (edema), drowsiness, dizziness, liver dysfunction, overgrowth of the gums, and mildly abnormal liver tests.
Side effects include:
Liver dysfunction and overgrowth of the gums also may occur. Cortiazem can cause mildly abnormal liver tests that usually return to normal with discontinuation of the medication. When Cortiazem is given to individuals with heart failure, symptoms of heart failure may worsen because these drugs reduce the ability of the heart to pump blood. Like other drugs for high blood pressure, Cortiazem is associated with sexual dysfunction.
Q: I have high blood pressure, take Cortiazem ER, and feel tired a lot. Could it be from this? And it always seems that my pulse rate is low when I take my pressure with the machine. How low is too low for your pulse rate? I do work out and am in good shape but not an athlete.
A: Cortiazem (Cardizem LA) is a medication used to treat hypertension (high blood pressure) and chest pain. Common side effects with Cortiazem are hypotension (abnormally low blood pressure), bradycardia (abnormally low heart beat), headache, fatigue, weakness, drowsiness, constipation or diarrhea, nausea, vomiting, facial flushing, and difficulty sleeping. A normal heart rate or heart beat is 60 to 100 beats per minute. A heart beat less than 60 beats per minute is defined as bradycardia. Some people with a slow heart beat are completely healthy, for example athletes tend to have a slower heart rate. But for other people, a slow heart beat may mean that not enough blood is being pumped to the body. This slow heart beat can cause fatigue and other symptoms. If you are experiencing a slow heart rate, consult with your physician or cardiologist right away. This is not a complete list of the side effects associated with Cortiazem. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Tell your health care provider about any negative side effects from prescription drugs. You can also report them to the U.S. Food and Drug Administration by visiting www.fda.gov/medwatch or by calling 1-800-FDA-1088. Leslie Ako-Mbo, PharmD
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Cortiazem can be fatal.
Overdose symptoms may include slow heartbeat, weakness, chest pain, shortness of breath, or fainting.
A pharmacokinetic interaction between Cortiazem and cyclosporine has been observed during studies involving renal and cardiac transplant patients. In renal and cardiac transplant recipients, a reduction of cyclosporine dose ranging from 15% to 48% was necessary to maintain cyclosporine trough concentrations similar to those seen prior to the addition of Cortiazem. If these agents are to be administered concurrently, cyclosporine concentrations should be monitored, especially when Cortiazem therapy is initiated, adjusted, or discontinued.
The effect of cyclosporine on Cortiazem plasma concentrations has not been evaluated.
ВїCГіmo se debe usar este medicamento?
Las presentaciones del Cortiazem son en tabletas, tabletas de liberaciГіn prolongada (acciГіn prolongada) y cГЎpsulas de liberaciГіn prolongada para administrarse por vГa oral. La tableta comГєn se toma en general tres o cuatro veces al dГa. La cГЎpsula y la tableta de liberaciГіn prolongada suelen tomarse una o dos veces al dГa. Pregunte a su farmacГ©utico si debe tomar Cortiazem con o sin alimentos, porque las instrucciones pueden variar con cada producto. Tome Cortiazem aproximadamente a la misma hora todos los dГas. Siga atentamente las instrucciones de la receta y pГdales a su mГ©dico o a su farmacГ©utico que le expliquen cualquier cosa que no entienda. Tome Cortiazem segГєn lo indicado. No aumente ni disminuya la dosis, ni la tome con mГЎs frecuencia que la indicada por su mГ©dico.
Trague las tabletas y las cГЎpsulas de liberaciГіn prolongada enteras; pero no las mastique ni las triture.
Probablemente, al principio, su mГ©dico le recete una dosis baja de Cortiazem y, luego, la aumente en forma gradual, no mГЎs de una vez cada 7 a 14 dГas, si estГЎ tomando la tableta o cГЎpsula de liberaciГіn prolongada, y no mГЎs de una vez cada 1 Гі 2 dГas, si estГЎ tomando la tableta comГєn.
Si se toma con regularidad, el Cortiazem puede controlar el dolor en el pecho, pero no detiene el dolor en el pecho una vez que se produce. Su mГ©dico podrГЎ darle un medicamento diferente para tomar cuando tiene dolor en el pecho.
El Cortiazem controla la presiГіn arterial alta y el dolor en el pecho (angina), pero no los cura. QuizГЎs transcurran hasta 2 semanas antes de que sienta el beneficio total del Cortiazem. Siga tomando Cortiazem aunque se sienta bien. No deje de tomar el Cortiazem sin consultar a su mГ©dico.
El Cortiazem puede provocar efectos secundarios. AvГsele a su mГ©dico si cualquiera de estos sГntomas es intenso o no desaparece:
- mareos o aturdimiento
- dolor de cabeza
- latidos cardГacos lentos
- congestiГіn nasal
Immune system suppressing drugs
Cortiazem can increase the amount of these medications in your body. This can cause more side effects. These drugs include:
Pregnancy and Cortiazem
There are not adequate studies to show that this drug is safe in pregnant women.
Cortiazem is excreted in breast milk, so women should not take it while breastfeeding.
Acute Hepatic Injury
Mild elevations of transaminases with and without concomitant elevation in alkaline phosphatase and bilirubin have been observed in clinical studies. Such elevations were usually transient and frequently resolved even with continued Cortiazem treatment. In rare instances, significant elevations in enzymes such as alkaline phosphatase, LDH, SGOT, and SGPT, and other phenomena consistent with acute hepatic injury have been noted. These reactions tended to occur early after therapy initiation (1 to 8 weeks) and have been reversible upon discontinuation of drug therapy. The relationship to Cortiazem hydrochloride is uncertain in some cases, but probable in some (see PRECAUTIONS).