Enhancing Healthcare Team Outcomes
Compro is a medication which can present with numerous side effects and drug-drug interactions. Therefore, close interprofessional coordination amongst physicians, nurses, pharmacists, and other healthcare providers is necessary to monitor for signs and symptoms related to the above. Working together with both team members and the patient is also essential to determine if Compro is clinically indicated and to increase medication compliance.
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How is vertigo treated?
Some cases of vertigo improve over time, without treatment. However, some people have repeated episodes for many months, or even years, such as those with Ménière's disease.
There are specific treatments for some causes of vertigo. A series of simple head movements (known as the Epley manoeuvre) is used to treat BPPV.
Medicines, such as Compro and some antihistamines, can help in the early stages or most cases of vertigo.
Many people with vertigo also benefit from vestibular rehabilitation training (VRT), which is a series of exercises for people with dizziness and balance problems.
Compro and Drug Interactions
If you are taking any of the following medications while taking Compro, your doctor will watch closely to guard against interactions:
- Thiazide diuretics, such as hydrochlorothiazide (Microzide) or chlorothiazide (Diuril). These can lower blood pressure too much when taken with Compro.
- Oral anticoagulants such as warfarin (Coumadin) can work less effectively when taken with Compro.
- Anticonvulsant medications (anti-epileptic drugs) may need to be dose-adjusted.
Increased Mortality in Elderly Patients with Dementia-Related Psychosis
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. Over the course of a typical 10-week controlled trial, the rate of death in drugtreated patients was about 4.5%, com- pared to a rate of about 2.6% in the placebo group. Although the causes of death were varied, most of the deaths appeared to be either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature. Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s ) of the patients is not clear. Compazine ® Compro Suppositories USP is not approved for the treatment of patients with dementia-related psychos is (see WARNINGS).
Studies have shown that older adults with dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and that may cause changes in mood and personality) who take antipsychotics (medications for mental illness) such as Compro have an increased chance of death during treatment.
Compro is not approved by the Food and Drug Administration (FDA) for the treatment of behavior problems in older adults with dementia. Talk to the doctor who prescribed this medication if you, a family member, or someone you care for has dementia and is taking Compro. For more information, visit the FDA website: http://www.fda.gov/Drugs
Before taking Compro
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking Compro it is important that your doctor knows:
- If you are pregnant or breast-feeding.
- If you have a heart condition or blood vessel disease.
- If you have liver, k >
Which drugs or supplements interact with Compro?
- Acetylcholinesterase inhibitors may decrease the effectives of Compro. Centrally acting acetylcholinesterase inhibitors may increase the neurotoxic effects of antipsychotic agents.
- Combining Compro with alcohol, kava kava, CNS depressants, and cannabis may increase the risk of CNS depressant side effects.
- Antacids may decrease the absorption of Compro.
- Compro may cause anticholinergic side effects such as dry mouth, constipation, dry eyes, decreased urinary output, and mental confusion. Combining agents with similar anticholinergic effects increases the risk of experiencing such adverse events.
- Compro may increase the blood levels of dofetilide (Tikosyn). Use of both drugs is not recommended.
- Deferoxamine (Desferal) may increase the risk of experiencing side effects of Compro treatment. Combination use has resulted in the prolonged loss of consciousness.
- Metoclopramide (Reglan) may increase the side effects of antipsychotic agents. Combination use is not recommended.
- Compro may increase the CNS depressant effects of orphenadrine (Norflex) or paraldehyde (Paral). Combination use is not recommended.
- Combining Compro and potassium chloride may result in an increase in the ulcerogenic effect of potassium chloride (Klor-Con). Combination use is generally not recommended.
- Combining Compro with thalidomide (Thalomid) may increase the risk of experiencing CNS depressant side effects. This combination is generally not recommended.
Compro (Compazine, Compro) is an antimetic drug prescribed to treat nausea and vomiting in adults and the management of schizophrenia, and non-psychotic anxiety. Side effects, drug interactions, dosing and storage information, and pregnancy safety should be reviewed prior to taking this medication.