Which drugs or supplements interact with Clozix?
Risperidone (Risperdal) may cause an increase in the amount of Clozix in the blood. This could lead to an increased risk of side effects from Clozix.
What causes Clozix withdrawal symptoms?
Clozix withdrawal symptoms are thought to manifest as a result of neurotransmitter imbalances that persist within the brain after treatment is ended. When a person first begins using Clozix, the drug modifies the actions of various neurotransmitters in the brain. Ongoing or continued regular use of Clozix causes the brain to adjust to its regularly elicited effects, such that daily administration of the drug becomes necessary in order to maintain balance of neurotransmitters.
How Clozix affects brain activity
- Histamine receptors
- Dopamine receptors
- Adrenergic receptors
- Acetylcholine receptors
- Serotonin receptors
If and/or when a person stops using Clozix after a long-term of daily use, the brain will continue to expect receiving the drug (to maintain neurotransmitter balance). However, because the brain will no longer receive Clozix, neurotransmitter activity becomes chaotic, irregular, and significantly imbalanced. It is the substantial imbalance across neurotransmitter systems such as: histamine, dopamine, norepinephrine, acetylcholine, and serotonin – that likely account for most Clozix withdrawal symptoms.
What Is Clozix (Clozaril)?
Clozix is the generic form of the brand-name drug Clozaril, which is used to treat symptoms of schizophrenia.
Schizophrenia is a mental illness that's characterized by disturbed thinking, unusual emotions, and hallucinations.
Clozix is in a class of drugs known as atypical antipsychotics, and is used to treat schizophrenia or reduce the risk of suicidal behavior in people with schizophrenia or other mental health disorders.
Clozix, manufactured by Novartis Pharmaceuticals, was first approved by the Food and Drug Administration (FDA) in 1989 for people with treatment-resistant schizophrenia.
Information on Clozix
Clozix (marketed as Clozaril, Fazaclo ODT, Versacloz and generics) is an antipsychotic medicine used to treat schizophrenia in patients whose symptoms are not controlled with standard antipsychotic drugs. Clozix is also used in patients with recurrent suicidal behavior associated with schizophrenia or schizoaffective disorder.
While Clozix is beneficial for some patients, there are risks associated with this drug. Specifically, Clozix can decrease the number of neutrophils, a type of white blood cell, that function in the body to fight off infections. When neutrophils are significantly decreased, severe neutropenia may result and the body may become prone to infections. For this reason, patients taking Clozix need to have their absolute neutrophil count (ANC) monitored on a regular basis. This monitoring requirement serves as the basis for the Clozix Risk Evaluation and Mitigation Strategy (REMS).
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Clozix only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2019 Cerner Multum, Inc. Version: 18.01.
For the Consumer
Applies to Clozix: oral suspension, oral tablet, oral tablet disintegrating
Significant risk of agranulocytosis in humans.
Clozix should be used with care in patients with concurrent cardiovascular disease.
In dogs Clozix caused excessive salivation and ataxia, and blocked avoidance behaviors.
Before taking Clozix
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking Clozix it is important that your doctor knows:
- If you are pregnant or breastfeeding.
- If you have a heart condition or blood vessel disease.
- If you have liver, k >
Rated Clozix for Schizophrenia Report
I am Schizoaffective, bipolar type. I do not have auditory or visual hallucinations, but I take this drug for paranoia and paranoid dillusions. It works great for my paranoia. Upon taking the drug, I lose all paranoia. I have racing thoughts, but when I take the drug, nothing goes on in my mind at all. It enables me to be comfortable in my own skin. I take 250mg at bedtime. Side effects include extreme figiditiness. Not being able to hold still, having the need to pace back and forth, restlessness. This is definitely caused by the drug only. When I take the drug at night, before I wake up, I have extreem stiffness. Walking is like a zombie, and is just really hard. I have to take baby steps. When I wake up, my pillow is always covered in drool. This med causes extreme drooling at night. It also causes markedly increased appetite. It is an excellent anxiolytic, and causes a lot of drowsiness at night, which once I have gotten adequate sleep (10+ hours), goes away and turns to anti-anxiety effects. It does change my whole personality, but for the better. Reduces mood swings.
If you suspect an overdose, you should contact a poison control center or emergency room immediately.
You can get in touch with a poison control center at (800) 222-1222.