Clozapina is a prototypical atypical antipsychotic whose metabolism covaries with CYP1A2 activity. Because clinical studies indicate a positive association between Clozapina plasma concentration and antipsychotic response and since the extent of antipsychotic response varies markedly among patients, polymorphism of CYP1A2 and/or its regulators has been studied in an attempt to individualize Clozapina therapy through identification of responders and nonresponders to the drug. There appears to be an association between the CYP1A2∗1F allele and enhanced Clozapina clearance, increased dose requirement and nonresponsiveness, particularly in smokers, and increased plasma concentrations and adverse effects after discontinuation of smoking. A few studies did not find this relationship. CYP1A2∗1C and CYP1A2∗1D (−2467delT) appear to be associated with increased Clozapina exposure and adverse effects.
What are the side effects of Clozapina?
The most common side effect of Clozapina is drowsiness.
Dizziness is another side effect of Clozapina. Dizziness may occur in 1 of 5 persons taking Clozapina. In some cases this may be due to orthostatic hypotension, a marked decrease in blood pressure that occurs when going from a lying or sitting position to a standing position. The drop in blood pressure may lead to loss of consciousness or even cardiac and respiratory arrest. This reaction is more common during the first few weeks of therapy while the dose is increasing, when drug is stopped briefly, or when patients are taking benzodiazepines such as diazepam (Valium) or other anti-psychotic drugs.
Seizures have occurred in approximately 1 of every 20 to 30 persons receiving Clozapina. Patients receiving higher doses seem to be at higher risk.
How should I take Clozapina?
Take Clozapina exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Clozapina can be taken with or without food.
The orally-disintegrating tablet (FazaClo) can be taken without water. Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet. Use dry hands to remove the tablet and place it in your mouth. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. If desired, you may drink liquid to help swallow the dissolved tablet.
If your doctor has prescribed one-half of an orally-disintegrating tablet, you will need to break the tablet in half. Throw the other half away. Do not save it for later use.
Clozapina can lower blood cells that help your body fight infections, especially in women and older adults, and in people who are malnourished or have serious medical problems. This can make it easier for you to develop a serious or life-threatening infection. Your blood will need to be tested often. Your future treatments may be delayed based on the results of these tests.
If you need surgery, tell the surgeon ahead of time that you are using Clozapina. You may need to stop using the medicine for a short time.
You should not stop using Clozapina suddenly or you could have unpleasant withdrawal symptoms. Follow your doctor's instructions about tapering your dose.
Clozapina can have long lasting effects on your body. You may need frequent medical tests for a short time after you stop using this medicine.
Store at room temperature away from moisture and heat.
If you suspect an overdose, you should contact a poison control center or emergency room immediately.
You can get in touch with a poison control center at (800) 222-1222.
Clozapina and Alcohol
Consuming alcohol can make you drowsier while taking Clozapina. You should talk to your doctor about this possible interaction.
Michael Stewart, Reviewed by Sid Dajani | Last edited 19 Jun 2017 | Certified by The Information Standard
Clozapina is prescribed for mental health problems which affect the way you think, feel or behave.
It is important that you have regular check-ups and blood tests.
Make sure you read all the printed information you are given. If there is anything you are unsure about, ask your doctor or clinic for further advice.Lemon balm: Lemon balm is a supplement that can help increase relaxation and reduce stress levels. If you’re feeling highly stressed during Clozapina withdrawal, this may be a supplement to cons >How to withdraw from Clozapina (Recommendations)
There’s no perfect way to withdraw from Clozapina, however, some general recommendations should be made. Keep these recommendations in mind before you decide to withdraw from Clozapina.
- Psychiatrist oversight: Clozapina should never be discontinued without the help of a psychiatrist. Anyone undergoing Clozapina withdrawal should be monitored regularly by a psychiatrist. Psychiatric oversight will help minimize likelihood of severe withdrawal symptoms via treatment with pharmacologic interventions.
- Taper slowly: Medical literature suggests that Clozapina should be discontinued very slowly, at a rate no faster than 50 mg/week. Some sources suggest that tapering the dosage at a rate of 10% per month is >How long does Clozapina withdrawal last? (Duration)
The length of time it takes to get over Clozapina withdrawal will vary depending on the specific user. Some individuals might discontinue Clozapina and experience a withdrawal that persists for a few weeks, whereas others might quit Clozapina and endure withdrawal symptoms that last for months. Because withdrawal is individualized, there’s no exact “timeline” that can be referenced to suggest a specific duration of withdrawal.
Nevertheless, assuming the drug was discontinued with psychiatric oversight and a slow taper, most individuals should notice improvements in withdrawal symptoms within 2 to 12 weeks of their final dose. Understand that withdrawal symptom improvements do not mean that withdrawal is necessarily over. If you work closely with your psychiatrist and do everything you can to recover from withdrawal, it may end up shorter than you expect.
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to Clozapina.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
What Other Drugs Interact with Clozapina?
If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
Severe Interactions of Clozapina include:
Clozapina has serious interactions with at least 48 different drugs.
Clozapina has moderate interactions with at least 371 different drugs.
Mild Interactions of Clozapina include:
Clozapina has moderate interactions with at least 108 different drugs.
Mild Interactions of Clozapina include:
This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.
What should I avoid while taking Clozapina?
Clozapina can cause severe dizziness, slow heartbeats, fainting, or seizures. Do not take more of this medicine than recommended. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Dizziness or severe drowsiness can cause falls, fractures, or other injuries.
Avoid drinking alcohol. Dangerous side effects could occur.
What affects the severity of Clozapina withdrawal symptoms?
The difficulty of Clozapina withdrawal is likely influenced by several important factors. It is thought that the most important factors in determining withdrawal severity include: duration of Clozapina treatment, Clozapina dosage, and speed of Clozapina discontinuation. That said, other factors could also influence withdrawal severity, including: usage of other substances, lifestyle, and genetics.
Clozapina has been associated with venous thromboembolism. The mortality rate associated with pulmonary embolism has been estimated to be about 28 times higher than in the general population of similar age and sex; it is not clear whether pulmonary embolism can be attributed to Clozapina or some characteristic of its users . A new case of pulmonary embolism has been reported .
A 45-year-old man became acutely confused after taking an overdose of Clozapina, which he had previously been taking for 6 months. He had acute dyspnea due to bilateral pulmonary emboli. He was not overweight, but was a heavy smoker; plasma concentrations of Clozapina are lower in smokers than in non-smokers .