Cetron tablets

Cetron

  • Active Ingredient: Ondansetron
  • 8 mg, 4 mg
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What is Cetron?

The active ingredient of Cetron brand is ondansetron. Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting. The molecular formula is C18H19N3O•HCl•2H2O, representing a molecular weight of 365.9. Ondansetron HCl dihydrate is a white to off-white powder that is soluble in water and normal saline. Each 4 mg Ondansetron tablet, USP for oral administration contains Ondansetron hydrochloride dihydrate equivalent to 4 mg of Ondansetron. Each 8 mg Ondansetron tablet, USP for oral administration contains Ondansetron hydrochloride dihydrate equivalent to 8 mg of Ondansetron. Each tablet also contains the inactive ingredients croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinized starch, titanium dioxide, triacetin, and iron oxide yellow (8 mg tablet only). This product meets USP Dissolution Test 3.

Used for

Cetron is used to treat diseases such as: Alcohol Dependence, Gastroenteritis, Nausea/Vomiting, Nausea/Vomiting, Chemotherapy Induced, Nausea/Vomiting, Postoperative, Nausea/Vomiting, Radiation Induced, Obsessive Compulsive Disorder, Postanesthetic Shivering, Pruritus.

Side Effect

Possible side effects of Cetron include: redness of the face, neck, arms, and occasionally, upper chest; slow or irregular breathing; difficulty with breathing; difficulty with passing urine (dribbling); shortness of breath; Difficulty with speaking.

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Proper use of Cetron

This section provides information on the proper use of a number of products that contain Cetron. It may not be specific to Zofran ODT. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

To use the oral disintegrating tablet:

  • Make sure your hands are dry.
  • Do not push the tablet through the foil backing of the package. Instead, gently peel back the foil backing and remove the tablet.
  • Immediately place the tablet on top of the tongue. The tablet will dissolve in seconds, and you may swallow it with your saliva. You do not need to drink water or other liquid to swallow the tablet.

To use the oral soluble film:

  • Make sure your hands are clean and dry before and after using this medicine.
  • Fold the pouch along the dotted line to expose the tear notch.
  • While still folded, tear the pouch carefully along the edge and remove the film out from the pouch.
  • Put the soluble film immediately on top of your tongue where it will dissolve in 4 to 20 seconds. Do not chew or swallow the film whole.
  • Once the film is dissolved, you may swallow with or without water.

If you vomit within 30 minutes after using this medicine, take the same amount of medicine again. If vomiting continues, check with your doctor.

This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Cetron uses

Cetron is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment.

Allergy warning

Cetron can cause a severe allergic reaction. Symptoms can include:

  • flushing
  • trouble breathing
  • swelling of your throat or tongue
  • dizziness
  • coughing

If you develop these symptoms, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately or seek emergency medical treatment:

  • blurred vision or vision loss
  • rash
  • hives
  • itching
  • swelling of the eyes, face, lips, tongue, throat, hands, feet, ankles, or lower legs
  • hoarseness
  • difficulty breathing or swallowing
  • chest pain
  • shortness of breath
  • dizziness, light-headedness, or fainting
  • fast, slow or irregular heartbeat
  • agitation
  • hallucinations (seeing things or hearing voices that do not exist)
  • fever
  • excessive sweating
  • confusion
  • nausea, vomiting, or diarrhea
  • loss of coordination
  • stiff or twitching muscles
  • seizures
  • coma (loss of consciousness)

Cetron may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Cetron in the elderly.

Warnings for other groups

For pregnant women: There haven’t been enough studies done in humans to be certain how Cetron might affect a fetus when the mother takes it. Research in animals has not shown a risk to the fetus. However, animal studies do not always predict the way humans would respond.

Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used in pregnancy if clearly needed.

For women who are breastfeeding: Cetron may pass into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors: The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.

For children: This medication has not been studied in children younger than 4 years. It should not be used in children of this age range.

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

How it works

Cetron belongs to a class of drugs called antiemetics. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. Antiemetics are drugs that reduce nausea and vomiting.

Cetron works by blocking the release of the chemical serotonin in the gut and the central nervous system. This keeps serotonin from causing nausea and vomiting.

Cetron orally disintegrating tablet may cause drowsiness. It can also cause other side effects.

Drug forms and strengths

Generic: Cetron

  • Form: orally disintegrating tablet
  • Strengths: 4 mg, 8 mg

Brand: Zofran ODT

  • Form: orally disintegrating tablet
  • Strengths: 4 mg, 8 mg

Pediatric Dose for Nausea/Vomiting – Postoperative

  • Use: Prevention of postoperative nausea and vomiting

Parenteral Cetron:

  • 1 month to 12 years
    • Less than 40 kg: Recommended dose: 0.1 mg/kg IV over 2 to 5 minutes immediately prior to/following anesthesia induction or postoperatively (nausea and/or vomiting occurring shortly after surgery)
    • 40 kg and greater: Recommended dose: 4 mg IV over 2 to 5 minutes immediately prior to/following anesthesia induction or postoperatively (nausea and/or vomiting occurring shortly after surgery)

How to store Cetron

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

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