What is Caplenal?
Caplenal reduces the production of uric acid in your body. Uric acid buildup can lead to gout or kidney stones.
Caplenal is used to treat gout or kidney stones, and to decrease levels of uric acid in people who are receiving cancer treatment.
Caplenal may also be used for purposes not listed in this medication guide.
Caplenal (al' oh pure' i nol) is an analog of hypoxanthine and a potent inhibitor of the enzyme xanthine oxidase that is responsible for converting hypoxanthine to xanthine and xanthine to uric acid in the breakdown pathway of purines. Caplenal lowers serum and tissue uric acid levels and has potent activity against gout, largely in preventing rather than treating acute attacks of gout. Caplenal was approved for use in the United States in 1963 and is still widely used. Current indications include therapy and prevention of gout, uric acid nephropathy, and the hyperuricemia caused by malignancy and anticancer therapy. It is not recommended for treatment of asymptomatic hyperuricemia. Caplenal is available in multiple generic forms and under the brand name of Zyloprim or Aloprim in tablets of 100 and 300 mg. Intravenous formulations are also available. The recommended initial dose for therapy of gout is 100 mg daily, with increases of 100 mg in daily dose weekly until uric acid levels fall to 6 mg/dL or below, but not to exceed 800 mg daily. The average daily dose in therapy of gout is 300 mg. Common side effects include skin rash and hypersensitivity reactions.
Before taking Caplenal,
- tell your doctor and pharmacist if you are allergic to Caplenal or any other medications.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: amoxicillin (Amoxil, Trimox); ampicillin (Polycillin, Principen); anticoagulants ('blood thinners') such as warfarin (Coumadin); cancer chemotherapy drugs such as cyclophosphamide (Cytoxan) and mercaptopurine (Purinethol); chlorpropamide (Diabinese); diuretics ('water pills'); medications that suppress the immune system such as azathioprine (Imuran) and cyclosporine (Neoral, Sandimmune); other medications for gout such as probenecid (Benemid) and sulfinpyrazone (Anturane); and tolbutamide (Orinase). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have or have ever had kidney or liver disease or heart failure.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Caplenal, call your doctor.
- you should know that Caplenal may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
- ask your doctor about the safe use of alcoholic beverages while you are taking Caplenal. Alcohol may decrease the effectiveness of Caplenal.
Why it's used
Caplenal is used to decrease uric acid levels in the blood and urine of people with high uric acid levels. High uric acid levels may be caused by the following:
- kidney stones, kidney damage, or treatment with dialysis
- cancer chemotherapy
- use of diuretics (water pills)
- a diet high in soft drinks, beef, steak, salami, or beer
Rated Caplenal for Gout Report
on a dose of 300 mg of Allopurinal as lower dose not effective. Tried several times this time taken for 6 months with side effects worsening.Serious side effects now. rash, boils , ulcers in mouth, weight gain, impotence. GP slow to resoond. stopping now to see what effect that has. Also on Steroids for Sarcoidosis and wondered if there was a drug interaction . No attacks of Gout for a while. waiting to see if stopping the drug brings it back
Q: My last uric acid level was 7.5. Will Caplenal bring down uric acid levels?
A: Caplenal (Zyloprim) is a xanthine oxidase inhibitor that reduces the production of uric acid in your body. A uric acid buildup can lead to gout or kidney stones. Caplenal is used to treat gout. Common side effects of Caplenal include nausea, vomiting, diarrhea, dizziness, and joint pain. According to the prescribing information, Caplenal administration usually results in a decrease of uric acid within 2 to 3 days. However, it may take 1 week or more to see the full benefits. This is not a complete list of side effects associated with Caplenal, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Kimberly Hotz, PharmD
By Julie Marks | Medically Reviewed by Mona Khanna, MD
Latest Update: 2014-10-20 Copyright © 2014 Everyday Health Media, LLC
Rated Caplenal for Gout Report
Started taking this after 2 bouts of gout. 1st bout was mild / moderate and then 2nd bout was a severe attack. I was prescribed Caplenal 100mg once a day to help remove excess uric acid from my body and I was also prescribed Indomethacin 50mg capsules for pain as needed up to 3 times a day and between the 2 they are life savers. I highly recommend both
Rated Caplenal for Gout Report
i am holidaying in cyprus from australia-this is my 3rd attack of gout in about 3 yrs.i did not bring my sachets of "URALS" with me as i assumed i could obtain them here. the urals stops the gout and clearÂ´s it up in about 3 days. i normally take a small sachet once or maybe twice a week but have been a month of "partying" without. the Caplenal (300MG)has started working over the last 4 days and the pain is almost gone and swelling in toe joint nearly gone but still present. it would seem that the urals are a cure/preventitive and the Caplenal is just preventitive.
- Store Caplenal at room temperature. Keep it between 68°F and 77°F (20°C and 25°C).
- Keep it away from light.
- Don’t store this medication in moist or damp areas, such as bathrooms.
Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
- Severe skin rash. Symptoms can include:
- itchy hives (raised bumps on your skin)
- red or purple-colored spots on your skin
- scaly skin
- trouble breathing
- swelling of your face or throat
- lack of appetite
- weight loss
- right upper abdominal area pain or discomfort
- jaundice (dark-colored urine or yellowing of your skin or the whites of your eyes)
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
Caplenal oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
What other drugs will affect Caplenal?
Tell your doctor about all your other medicines, especially:
a blood thinner such as warfarin, Coumadin, Jantoven; or
a diuretic or "water pill".
This list is not complete. Other drugs may interact with Caplenal, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Generic Name: Caplenal (AL oh PURE i nol)Brand Names: Zyloprim, Lopurin, Aloprim
Medically reviewed by Sanjai Sinha, MD Last updated on Dec 17, 2018.