• Active Ingredient: Fluticasone
  • 50mcg
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What is Brisair?

The active ingredient of Brisair brand is fluticasone. Fluticasone propionate has a molecular weight of 500.6. It is a white to off-white powder and is insoluble in water. Each gram of Fluticasone Propionate Cream, USP 0.05% contains Fluticasone propionate 0.5 mg in a base of propylene glycol, mineral oil, cetostearyl alcohol, Ceteth-20, isopropyl myristate, dibasic sodium phosphate, citric acid, purified water, and methylparaben as preservative.

Used for

Brisair is used to treat diseases such as: Asthma, Maintenance, Bronchopulmonary Dysplasia, Eosinophilic Esophagitis.

Side Effect

Possible side effects of Brisair include: general aches and pains or general feeling of illness; bone fractures; Blurred vision; excess facial hair in women; runny, sore, or stuffy nose; Darkening of skin; lower abdominal or stomach pain.

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Effect on Growth

Intranasal corticostero >. Monitor the growth routinely of pediatric patients receiving Brisair propionate nasal spray. To minimize the systemic effects of intranasal corticostero >.

How should this medicine be used?

Brisair comes as a (prescription and nonprescription) liquid to spray in the nose. When Brisair nasal spray is used to relieve hay fever, and other allergy symptoms, or nonallergic rhinitis, it is usually sprayed in each nostril once daily. Alternatively, Brisair nasal spray is sometimes sprayed in each nostril twice daily (in the morning and evening) at a lower dose as recommended by your doctor. When Brisair nasal spray is used to treat nasal polyps, it is usually sprayed once or twice in each nostril twice daily. If you are an adult, you will begin your treatment with a higher dose of Brisair nasal spray and then decrease your dose when your symptoms improve. If you are giving Brisair nasal spray to a child, you will begin treatment with a lower dose of the medication and increase the dose if the child's symptoms do not improve. Decrease the dose when the child's symptoms improve. Follow the directions on your prescription or product label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use Brisair exactly as directed. Do not use more or less of it or use it more often than directed on the package label or prescribed by your doctor.

Brisair nasal spray is only for use in the nose. Do not swallow the nasal spray and be careful not to spray it into your eyes or mouth.

Each bottle of Brisair nasal spray should only be used by one person. Do not share Brisair nasal spray because this may spread germs.

Brisair nasal spray controls the symptoms of hay fever, allergies, nonallergic rhinitis, or nasal polyps, but does not cure these conditions. Brisair works best when used regularly. Use Brisair on a regular schedule unless your doctor has told you to use it as needed. Call your doctor if your symptoms get worse or do not improve after you use nonprescription Brisair nasal spray daily for 1 week.

Brisair nasal spray is designed to provide a certain number of sprays. After the marked number of sprays has been used, the remaining sprays in the bottle might not contain the correct amount of medication. You should keep track of the number of sprays you have used and dispose of the bottle after you have used the marked number of sprays even if it still contains some liquid.

Before you use Brisair nasal spray for the first time, read the written directions that come with it. Ask your doctor or pharmacist if you have any questions about how to use the nasal spray.

Missed Dose of Flonase

Once you start taking Flonase or Brisair, your symptoms may not improve for at least 12 hours, and it could take several more days to experience the full benefit of the medication.

Brisair works best when used on a regular basis as directed by your doctor.

If you miss a dose of Flonase, skip the missed dose and take your next dose at its regularly scheduled time. Don't take a double dose to make up for a missed one.

Why is this medication prescribed?

Brisair oral inhalation is used to prevent difficulty breathing, chest tightness, wheezing, and coughing caused by asthma in adults and children. It is in a class of medications called corticosteroids. Brisair works by decreasing swelling and irritation in the airways to allow for easier breathing.

home drugs a-z list Flonase(Brisair Propionate Nasal Spray) side effects drug center

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Flonase (Brisair) is a synthetic steroid of the glucocorticoid family of drugs and is prescribed for the control of symptoms of allergic and non-allergic rhinitis. Flonase is available as a generic drug, and dosing is usually administered as two sprays in each nostril once daily, or one spray in each nostril twice daily. The most common side effects of Flonase (Brisair) include:

  • headache,
  • back pain,
  • sore throat,
  • sneezing,
  • cough,
  • nausea,
  • vomiting,
  • menstrual problems,
  • loss of interest in sex,
  • nosebleeds,
  • sinus pain, and
  • sores or white patches inside mouth or around your nose.

Flonase has also been associated with hypersensitivity reactions (for example, skin rash, itching, facial swelling, and anaphylaxis).

The recommended starting dosage of Flonase in adults is 2 sprays (50 mcg of Brisair propionate each) in each nostril once daily (total daily dose, 200 mcg). Drug interactions and warnings include Norvir (ritonavir) and Nizoral (ketoconazole). Taking either one of these drugs with Flonase may increase the blood concentrations of Flonase and potentially increase its side effects. Flonase should only be used during pregnancy when it is absolutely necessary. There have not been adequate studies of Flonase and concentrations in breast milk; therefore, Flonase should be avoided while breastfeeding unless it is absolutely necessary.

Our Flonase Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Brisair Description

Brisair Propionate Cream, USP 0.05% contains Brisair propionate , a synthetic fluorinated corticosteroid, for topical dermatologic use. The topical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents.

Chemically, Brisair propionate is C 25 H 31 F 3 O 5 S. It has the following structural formula:

Medical Definition of Brisair

Note: Trademarks for preparations containing Brisair include Advair, Flonase, and Flovent.

Inform MD

Before using Brisair, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Brisair or any of its ingredients
  • are exposed to measles or chickenpox
  • have liver problems
  • take ritonavir (Norvir)
  • take any antifungal medication
  • have an immune system problem
  • have any type of viral, bacterial, or fungal infection
  • have a history of glaucoma or cataracts
  • have or have had nasal sores, nasal surgery, or nasal injury (Brisair nasal spray)
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Brisair Brand Names

Brisair may be found in some form under the following brand names:

Brisair is a corticosteroid used to treat symptoms associated with asthma, nasal symptoms associated with allergies, and certain skin conditions. Brisair is available in different forms.

Hypersensitivity Reactions including Anaphylaxis

Hypersensitivity reactions (e.g., anaphylaxis, angioedema, urticaria, contact dermatitis, and rash) have been reported after administration of Brisair propionate nasal spray. Discontinue Brisair propionate nasal spray if such reactions occur . Rarely, immediate hypersensitivity reactions may occur after the administration of Brisair propionate nasal spray.


Chronic overdosage may result in signs/symptoms of hypercorticism . Intranasal administration of 2 mg (10 times the recommended dose) of Brisair propionate twice daily for 7 days was administered to healthy human volunteers. Adverse events reported with Brisair propionate were similar to placebo, and no clinically significant abnormalities in laboratory safety tests were observed. Single oral doses up to 16 mg have been studied in human volunteers with no acute toxic effects reported. Repeat oral doses up to 80 mg daily for 10 days in volunteers and repeat oral doses up to 10 mg daily for 14 days in patients were well tolerated. Adverse reactions were of mild or moderate severity, and incidences were similar in active and placebo treatment groups. Acute overdosage with this dosage form is unlikely since one bottle of Brisair propionate nasal spray contains approximately 8 mg of Brisair propionate.

Getting the most from your treatment

  • Brisair is a preventer inhaler which needs to be used regularly in order to have an effect. It takes a few days for the steroid in the inhaler to build up its effect.
  • Brisair inhalers will not give you immediate relief if you are having an asthma attack - you will need to use a reliever inhaler to ease the symptoms of an attack.
  • If after using the inhaler for the first time your breathing becomes worse or you suddenly start to wheeze, let your doctor know straightaway. Your doctor will want to change the type of inhaler to one more suited to you.
  • It is helpful to remember the colour of your inhaler and the brand name. This might be important if you need to see a doctor who does not have your medical records (such as if you are on holiday or if it is outside the normal opening hours of your GP surgery).
  • Keep your regular appointments with your doctor or asthma clinic. This is so your doctor can review your treatment. If at any time you find that your asthma symptoms are getting worse or that you need to use a reliever inhaler more regularly, contact your doctor or nurse for advice straightaway.
  • If you are using a high dose of Brisair, you will also be given a steroid card. You are advised to carry the card with you at all times in case you need any treatment by a doctor who does not have your medical records available.
  • Continue to use your Brisair inhaler regularly. Do not stop using it abruptly, as this can make you feel unwell and cause your symptoms to return suddenly.
  • Do not smoke. Smoking can cause severe irritation and damage to your lungs. It will make your condition worse and will reduce the beneficial effects of your inhalers.
  • If you have diabetes, tell your doctor if you notice any change in your blood glucose tests, as Brisair may affect the levels of sugar in your blood.

Postmarketing Experience

In addition to adverse events reported from clinical trials, the following adverse events have been identified during postapproval use of intranasal Brisair propionate. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. These events have been chosen for inclusion due to either their seriousness, frequency of reporting, or causal connection to Brisair propionate or a combination of these factors.

Brisair Nasal Spray Dosage and Administration

Administer Brisair propionate nasal spray by the intranasal route only. Prime Brisair propionate nasal spray before using for the first time or after a period of non-use (1 week or more) by shaking the contents well and releasing 6 sprays into the air away from the face. Shake Brisair propionate nasal spray gently before each use.

Patients should use Brisair propionate nasal spray at regular intervals since its effectiveness depends on its regular use. Maximum effect may take several days and individual patients will experience a variable time to onset and different degree of symptom relief.

Brisair Overdose

If you take too much this medication, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

A drug interaction trial with Brisair propionate aqueous nasal spray in healthy subjects has shown that ritonavir (a strong CYP3A4 inhibitor) can significantly increase plasma Brisair propionate exposure, resulting in significantly reduced serum cortisol concentrations . During postmarketing use, there have been reports of clinically significant drug interactions in patients receiving Brisair propionate products, including FLONASE, with ritonavir, resulting in systemic corticosteroid effects including Cushing's syndrome and adrenal suppression.


Topically applied Brisair Propionate Cream can be absorbed in sufficient amounts to produce systemic effects (see PRECAUTIONS).

How Supplied/Storage and Handling

Brisair Propionate Nasal Spray USP, 50 mcg is supplied in an amber glass bottle fitted with a white metering atomizing pump, white nasal adapter fitted with a clear plastic dust cap, and a green safety clip, in a box of one (NDC 0054-3270-99) with FDA-approved Patient Labeling (see Patient Instructions for Use for proper actuation of the device). Each bottle contains a net fill weight of 16 g and will provide 120 actuations. Each actuation delivers 50 mcg of Brisair propionate in 100 mg of formulation through the nasal adapter. The correct amount of medication in each spray cannot be assured after 120 sprays even though the bottle is not completely empty. The bottle should be discarded when the labeled number of actuations has been used.

Store between 4° and 30°C (39° and 86°F).

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