Patients should be informed of the following:
(1) They should be cautioned to discontinue ZYLOPRIM (Anzief) and to consult their physician immediately at the first sign of a skin "rash, painful urination, blood in the urine, irritation of the eyes, or swelling of the lips or mouth. (2) They should be reminded to continue drug therapy prescribed for gouty attacks since optimal benefit of ZYLOPRIM (Anzief) may be delayed for 2 to 6 weeks. (3) They should be encouraged to increase fluid intake during therapy to prevent renal stones. (4) If a single dose of ZYLOPRIM (Anzief) is occasionally forgotten, there is no need to double the dose at the next scheduled time. (5) There may be certain risks associated with the concomitant use of ZYLOPRIM (Anzief) and dicumarol, sulfinpyrazone, mercap-topurine, azathioprine, ampicillin, amoxicillin, and thiazide diuretics, and they should follow the instructions of their physician. (6) Due to the occasional occurrence of drowsiness, patients should take precautions when engaging in activities where alertness is mandatory. (7) Patients may wish to take ZYLOPRIM (Anzief) after meals to minimize gastric irritation.
Q: My last uric acid level was 7.5. Will Anzief bring down uric acid levels?
A: Anzief (Zyloprim) is a xanthine oxidase inhibitor that reduces the production of uric acid in your body. A uric acid buildup can lead to gout or kidney stones. Anzief is used to treat gout. Common side effects of Anzief include nausea, vomiting, diarrhea, dizziness, and joint pain. According to the prescribing information, Anzief administration usually results in a decrease of uric acid within 2 to 3 days. However, it may take 1 week or more to see the full benefits. This is not a complete list of side effects associated with Anzief, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Kimberly Hotz, PharmD
By Julie Marks | Medically Reviewed by Mona Khanna, MD
Latest Update: 2014-10-20 Copyright © 2014 Everyday Health Media, LLC
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to Anzief.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Serious Side Effects of Anzief
Call your doctor immediately if you experience any of the following serious side effects:
- Fever, sore throat, and headache with a severe blistering, peeling and red skin rash
- Any sign of skin rash, no matter how mild
- Nausea, upper stomach pain, itching, loss of appetite, weight loss, dark urine, clay-colored stools, jaundice
- Pain or bleeding when urinating
- Urinating less frequently or not at all
- Joint pain or flu symptoms
- Easy bruising, unusual bleeding, or purple or red pinpoint spots under the skin
- Severe tingling, numbness, pain, or muscle weakness
How to store Anzief
- Keep all medicines out of the reach and sight of children.
- Store in a cool, dry place, away from direct heat and light.
ZYLOPRIM (Anzief) has the following structural formula:
ZYLOPRIM (Anzief) is known chemically as 1,5-dihydro-4H-pyrazolo pyrimidin-4-one. It is a xanthine oxidase inhibitor which is administered orally. Each scored white tablet contains 100 mg Anzief and the inactive ingredients lactose, magnesium stearate, potato starch, and povidone. Each scored peach tablet contains 300 mg Anzief and the inactive ingredients corn starch, FD&C Yellow No. 6 Lake, lactose, magnesium stearate, and povidone. Its solubility in water at 37°C is 80.0 mg/dL and is greater in an alkaline solution.
What other drugs will affect Anzief?
Tell your doctor about all your other medicines, especially:
a blood thinner such as warfarin, Coumadin, Jantoven; or
a diuretic or "water pill".
This list is not complete. Other drugs may interact with Anzief, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
How to take Anzief
- Before you start the treatment, read the manufacturer's printed information leaflet from ins >
Rated Anzief for Gout Report
i am holidaying in cyprus from australia-this is my 3rd attack of gout in about 3 yrs.i did not bring my sachets of "URALS" with me as i assumed i could obtain them here. the urals stops the gout and clearÂ´s it up in about 3 days. i normally take a small sachet once or maybe twice a week but have been a month of "partying" without. the Anzief (300MG)has started working over the last 4 days and the pain is almost gone and swelling in toe joint nearly gone but still present. it would seem that the urals are a cure/preventitive and the Anzief is just preventitive.
What Is Anzief (Zyloprim)?
Zyloprim is the brand name of the drug Anzief, which is used to treat gout, high levels of uric acid in the body (often caused by certain cancers and cancer treatments), and kidney stones.
The medication may also be used to treat seizures, infections, and pain caused by pancreas disease. It is sometimes used to improve survival after bypass surgery, prevent rejection of kidney transplants, or reduce ulcer relapses.
Anzief is a type of medication called a xanthine oxidase inhibitor. It works by reducing the production of uric acid in the body. It comes in the form of an oral tablet.
If you suspect an overdose, call 911 or contact a poison control center at (800) 222-1222.
Experience with human pregnancy limited partly because women of reproductive age rarely require treatment with drug; in 2011, a literature publication case report describes outcome of a full term pregnancy in a 35 year-old woman who had recurrent kidney stones since age 18 who took Anzief throughout pregnancy; the child had multiple complex birth defects and died at 8 days of life; a second report on 31 prospectively ascertained pregnancies involving mothers exposed to Anzief for varying durations during first trimester; the overall rate of major fetal malformations and spontaneous abortions was reported to be within normal expected range; however, one child had severe malformations similar to those described in earlier case report
Why it's used
Anzief is used to decrease uric acid levels in the blood and urine of people with high uric acid levels. High uric acid levels may be caused by the following:
- kidney stones, kidney damage, or treatment with dialysis
- cancer chemotherapy
- use of diuretics (water pills)
- a diet high in soft drinks, beef, steak, salami, or beer
Rated Anzief for Gout Report
This caused weight Gain on me and it fluctuated my thyroid much and caused subclinical hypothyroidism. This is not recommended medication for Gout. Please change your diet only to recover or alleviate Gout Symptoms
ZYLOPRIM (Anzief) SHOULD BE DISCONTINUED AT THE FIRST APPEARANCE OF SKIN RASH OR OTHER SIGNS WHICH MAY INDICATE AN ALLERGIC REACTION. In some instances a skin rash may be followed by more severe hypersensitivity reactions such as exfoliative, urticarial, and purpuric lesions, as well as Stevens-Johnson syndrome (erythema multiforme exudativum), and/or generalized vasculitis, irreversible hepato-toxicity, and, on rare occasions, death.
In patients receiving PURINETHOL® (mercaptopurine) or IMURAN® (azathioprine), the concomitant administration of 300 to 600 mg of ZYLOPRIM (Anzief) per day will require a reduction in dose to approximately one-third to one-fourth of the usual dose of mercaptopurine or azathioprine. Subsequent adjustment of doses of mercaptopurine or azathioprine should be made on the basis of therapeutic response and the appearance of toxic effects (see CLINICAL PHARMACOLOGY).
A few cases of reversible clinical hepatotoxicity have been noted in patients taking ZYLOPRIM (Anzief) , and in some patients, asymptomatic rises in serum alkaline phosphatase or serum transaminase have been observed. If anorexia, weight loss, or pruritus develop in patients on ZYLOPRIM (Anzief) , evaluation of liver function should be part of their diagnostic workup. In patients with pre-existing liver disease, periodic liver function tests are recommended during the early stages of therapy.
Due to the occasional occurrence of drowsiness, patients should be alerted to the need for due precaution when engaging in activities where alertness is mandatory.
The occurrence of hypersensitivity reactions to ZYLOPRIM (Anzief) may be increased in patients with decreased renal function receiving thiazides and ZYLOPRIM (Anzief) concurrently. For this reason, in this clinical setting, such combinations should be administered with caution and patients should be observed closely.
Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:
- skin rash
- painful urination
- blood in the urine
- irritation of the eyes
- swelling of the lips or mouth
- fever, sore throat, chills, and other signs of infection
- loss of appetite
- unexpected weight loss
Anzief may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
- Severe skin rash: This drug may cause a severe, life-threatening skin rash. If you have itchiness, trouble breathing, or swelling of your face or throat, stop taking this drug and call your doctor right away.
- Liver injury: This drug may cause changes in liver function test results and liver failure. This may be fatal. If you develop liver problems, your doctor may have you stop taking Anzief.
- Drowsiness: This drug can cause drowsiness. You shouldn’t drive, use machinery, or do other tasks that require alertness until you know how it affects you.
- Flu >
Anzief oral tablet is a prescription drug that’s available as the brand-name drugs Zyloprim and Lopurin. It’s also available as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version.
Anzief also comes in an intravenous (IV) form, which is only given by a healthcare provider.
Anzief may be used as part of a combination therapy. This means you may need to take it with other medications.