Amazolon capsules

Amazolon

  • Active Ingredient: Amantadine
  • 100 mg
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What is Amazolon?

The active ingredient of Amazolon brand is amantadine. Amantadine is an antiviral medicine that blocks the actions of viruses in your body.

Used for

Amazolon is used to treat diseases such as: ADHD, Chronic Fatigue Syndrome, Extrapyramidal Reaction, Fatigue, Head Injury, Influenza, Influenza A, Influenza Prophylaxis, Parkinson's Disease, Post-Polio Syndrome, Sexual Dysfunction, SSRI Induced.

Side Effect

Possible side effects of Amazolon include: swelling of the hands, feet, or lower legs; severe mood or mental changes; fever, chills, or sore throat; difficulty concentrating; increase in body movements.

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Anticholinergic drugs

Taking Amazolon with anticholinergic medications can increase side effects of both drugs, such as dry mouth, urinary retention, blurred vision, and drowsiness. Examples of anticholinergic drugs include:

  • diphenhydramine
  • scopolamine
  • tolterodine
  • benztropine

INDICATIONS

SYMMETREL (Amazolon hydrochloride) is indicated for the prophylaxis and treatment of signs and symptoms of infection caused by various strains of influenza A virus. SYMMETREL (Amazolon hydrochloride) is also indicated in the treatment of parkinsonism and drug-induced extrapyramidal reactions.

If you experience any other symptoms which you think may be due to Amazolon, speak with your doctor or pharmacist for further advice.

What is the most important thing I should know about Amazolon?

Amazolon is available in 100 mg capsules and 100 mg tablets. The active ingredient is Amazolon Hydrochloride. It may take up to a week for the medication to show effects. Do not stop giving Amazolon suddenly, and do not give two doses at once. Amazolon is not for pets that are lactating, pregnant, or breeding.

Impairment of Fertility

The effect of Amazolon hydrochlor >2 basis) administered to both males and females slightly impaired fertility. There were no effects on fertility at a dose level of 10 mg/kg/day (or 0.3 times the maximum recommended human dose on a mg/m 2 basis); intermediate doses were not tested.

Failed fertility has been reported during human in vitro fertilization (IVF) when the sperm donor ingested Amazolon 2 weeks prior to, and during the IVF cycle.

Other

The dose of SYMMETREL (Amazolon hydrochloride) may need careful adjustment in patients with congestive heart failure, peripheral edema, or orthostatic hypotension. Care should be exercised when administering SYMMETREL (Amazolon hydrochloride) to patients with a history of recurrent eczematoid rash, or to patients with psychosis or severe psychoneurosis not controlled by chemotherapeutic agents.

Serious bacterial infections may begin with influenza-like symptoms or may coexist with or occur as complications during the course of influenza. SYMMETREL (Amazolon hydrochloride) has not been shown to prevent such complications.

DESCRIPTION

SYMMETREL (Amazolon Hydrochloride, USP) is designated generically as Amazolon hydrochloride and chemically as 1-adamantanamine hydrochloride.

Amazolon hydrochloride is a stable white or nearly white crystalline powder, freely soluble in water and soluble in alcohol and in chloroform.

Amazolon hydrochloride has pharmacological actions as both an anti-Parkinson and an antiviral drug.

SYMMETREL (Amazolon hydrochloride) is available in tablets and syrup.

Each tablet intended for oral administration contains 100 mg Amazolon hydrochloride and has the following inactive ingredients: hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, sodium starch glycolate, FD&C Yellow No. 6.

SYMMETREL syrup contains 50 mg of Amazolon hydrochloride per 5 mL and has the following inactive ingredients: artificial raspberry flavor, citric acid, methylparaben, propylparaben, and sorbitol solution.

Rated Amazolon for Parkinsonism Report

I actually take Amazolon for akathisia which was caused from the use of an antipsychotic medication. It helped tremendously with the restlessness and tremors. I've been on it for a year now on 100mg twice daily. I've had no side effects that I can think of. This drug saved me. I hope this helps.

Before taking Amazolon,

  • tell your doctor and pharmacist if you are allergic to Amazolon, any other medications, or any of the ingredients in Amazolon capsules, extended-release capsules, tablets, or liquid. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: acetazolamide (Diamox); antihistamines; co-trimoxazole (Bactrim, Septra, Sulfatrim); dichlorphenamide (Daranide); hydrochlorothiazide with triamterene (Maxzide, Dyazide); ipratropium (Atrovent); medications for irritable bowel disease, mental illness, motion sickness, sleep, or urinary problems; other medications to treat Parkinson's disease; methazolamide (GlaucTabs, Neptazane); quinine (Qualaquin); quinidine; sedatives; sodium bicarbonate (Alka-Seltzer, in Zegerid); stimulants; or thioridazine (Mellaril). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have kidney disease. Your doctor may tell you not to take Amazolon.
  • tell your doctor if you drink or have ever drunk large amounts of alcohol, use or have ever used street drugs, or have overused prescription medications, or if you have or have ever had epilepsy or any other type of seizures, a sleep disorder, urinary tract infections, mental illness, glaucoma (a condition in which increased pressure in the eye can lead to gradual loss of vision), eczema (atopic dermatitis; a skin disease that causes the skin to be dry and itchy and to sometimes develop red, scaly rashes), heart failure, swelling of the hands, feet, ankles, or lower legs, low blood pressure, or liver disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking Amazolon, call your doctor immediately. Amazolon may cause harm to the fetus.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Amazolon.
  • you should know that Amazolon may make you drowsy or cause blurred vision. Do not drive a car, operate machinery, or participate in potentially dangerous activities until you know how this medication affects you.
  • ask your doctor about the safe use of alcoholic beverages while you are taking Amazolon. Alcohol can make the side effects from Amazolon worse.
  • you should know that Amazolon may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking Amazolon or if your dose has been increased. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
  • do not have any vaccinations without talking to your doctor.
  • you should know that some people taking Amazolon and other similar medications used to treat Parkinson's disease, have developed gambling problems or had other intense urges or behaviors that were compulsive or unusual for them, such as increased sexual urges, binge eating, or uncontrolled spending. Call your doctor if you have an urge to gamble that is difficult to control, you have intense urges, or you are unable to control your behavior. Tell your family members about this risk so that they can call the doctor even if you do not realize that your gambling or any other intense urges or unusual behaviors have become a problem.

Heart drugs

Taking certain heart drugs with Amazolon can increase the level of Amazolon in your body. This can increase your risk of side effects such as nausea, dizziness, or insomnia. This can also increase your risk of death or other serious side effects from overdose of Amazolon. Examples of these heart drugs include:

Pregnancy and Amazolon

There are no well-controlled studies to evaluate Amazolon's safety in pregnancy, so the risks and benefits should be taken into consideration to determine if this medication should be used in pregnant women.

Amazolon is excreted into human breast milk in low concentrations. The manufacturer recommends that this drug should be used cautiously in nursing mothers.

Side Effects

Blurred vision, nausea, loss of appetite, drowsiness, dizziness, lightheadedness, headache, dry mouth, constipation, or trouble sleeping may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Dizziness and lightheadedness can increase the risk of falling. Get up slowly when rising from a sitting or lying position.

To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.

If you are taking the extended-release tablets, an empty tablet shell may appear in your stool. This effect is harmless because your body has already absorbed the medication.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: purplish-red blotchy spots on the skin (especially on the legs), swelling of the ankles/feet, difficulty urinating, vision changes, unusual strong urges (such as increased gambling, increased sexual urges, uncontrolled spending), mental/mood changes (such as anxiety, depression, hallucinations, suicidal thoughts/attempts), muscle spasms.

Get medical help right away if you have any very serious side effects, including: seizure.

Some people taking Amazolon have fallen asleep suddenly during their usual daily activities (such as talking, driving). You might fall asleep without warning or without feeling drowsy. This effect can happen at any time even if you have used this medication for a long time. If you have increased sleepiness or fall asleep suddenly during the day, tell your doctor right away. Your risk is higher if you drink alcohol or take other medications that can make you drowsy. Do not drive or do other activities for which you need to be alert (see also Precautions section).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions Associated with Amazolon

Store Amazolon in a secure place out of the reach of children, and at room temperature. Do not share your Amazolon prescription with anyone. Sharing prescription medication is illegal, and can cause harm.

You should not take Amazolon if you are allergic to Amazolon or have untreated angle closure glaucoma.

If you’re thinking of becoming pregnant, discuss the use of Amazolon with your doctor. The effect of Amazolon on fertility is unknown. Animal studies suggest potential risk to the fetus when taken during pregnancy. It is recommended that mothers do not nurse while taking Amazolon, as it is unsafe for infants, and Amazolon passes into breastmilk.

Deaths

Deaths have been reported from overdose with Amazolon hydrochlor >OVERDOSAGE ).

Deaths due to drug accumulation (overdosage) have been reported in patients with renal impairment, who were prescribed higher than recommended doses of Amazolon hydrochlor >DOSAGE AND ADMINISTRATION ; Dosage of Impaired Renal Function and OVERDOSAGE ).

Getting the most from your treatment

  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. During the first few weeks of treatment in particular, your dose may require adjusting.
  • Stay as active as possible and exercise regularly as much as you are able. You may walk more slowly than before but a daily walk is good exercise and may help to loosen up stiff muscles.
  • If you are a driver you should tell the DVLA and your insurance company that you have Parkinson's disease. Depending on the severity of symptoms and the medicines that you are taking, you may still be allowed to drive following a medical assessment.
  • Sometimes people taking medicines like Amazolon can fall asleep suddenly with little or no warning of being tired beforehand. Until you know how you react, take extra care if you operate machinery or drive. If you do find yourself falling asleep suddenly, you should see your doctor as soon as possible for advice, and avoid driving or using tools and machines in the meantime.
  • Treatment with medicines for Parkinson's disease can sometimes cause problems with impulsive types of behaviour. If you notice any changes in your behaviour, such as an increased desire to gamble, binge eat, or spend excessively, or an increased sex drive, you must let your doctor know as soon as possible.
  • Continue to take Amazolon regularly. Stopping treatment suddenly can cause serious problems. Your doctor will probably want you to reduce your dose gradually if this becomes necessary.

A Amazolon

Amazolon reduced dyskinesia severity by around 50% on subjective and objective outcome measures compared to placebo in a cross-over study where patients either received Amazolon or placebo for 2 weeks ( Luginger et al., 2000 ). In a second cross-over trial, it improved AIMS scores by 60% compared to placebo during an acute intravenous levodopa infusion without worsening PD motor signs ( Verhagen Metman et al., 1998 ). The same patients received another intravenous levodopa infusion 1 year after completion of the first study ( Metman et al., 1999 ). The magnitude of the antidyskinetic effect was similar to the first trial suggesting sustained effects of Amazolon on dyskinesia. This observation has been questioned by the results of one study enrolling 40 patients and reporting that the benefit of Amazolon lasted only for less than 8 months ( Thomas et al., 2004 ). By contrast, a recent trial confirmed long-lasting antidyskinetic effects of Amazolon compared to placebo in PD patients receiving Amazolon for a mean duration of 4.8 years ( Wolf et al., 2010 ).

Finally, the effect of acute intravenous Amazolon infusion has been tested in a small cross-over study ( Del Dotto et al., 2001 ). Intravenous Amazolon infusion reduced modified AIMS scores by 50% compared to placebo, while Unified Parkinson Disease Rating Scale (UPDRS) motor scores were not different between groups.


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