Amal tablets

Amal

  • Active Ingredient: Ondansetron
  • 8 mg, 4 mg
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What is Amal?

The active ingredient of Amal brand is ondansetron. Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting. The molecular formula is C18H19N3O•HCl•2H2O, representing a molecular weight of 365.9. Ondansetron HCl dihydrate is a white to off-white powder that is soluble in water and normal saline. Each 4 mg Ondansetron tablet, USP for oral administration contains Ondansetron hydrochloride dihydrate equivalent to 4 mg of Ondansetron. Each 8 mg Ondansetron tablet, USP for oral administration contains Ondansetron hydrochloride dihydrate equivalent to 8 mg of Ondansetron. Each tablet also contains the inactive ingredients croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinized starch, titanium dioxide, triacetin, and iron oxide yellow (8 mg tablet only). This product meets USP Dissolution Test 3.

Used for

Amal is used to treat diseases such as: Alcohol Dependence, Gastroenteritis, Nausea/Vomiting, Nausea/Vomiting, Chemotherapy Induced, Nausea/Vomiting, Postoperative, Nausea/Vomiting, Radiation Induced, Obsessive Compulsive Disorder, Postanesthetic Shivering, Pruritus.

Side Effect

Possible side effects of Amal include: Blurred vision; chest tightness or heaviness; hiccups; unusual tiredness or weakness; tightness in the chest; difficulty with swallowing; loss of appetite; redness of the skin.

How to Buy Amal tablets online?

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Also known as Zofran ODT

A carbazole derivative with antiemetic activity. As a selective serotonin receptor antagonist, Amal competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. (NCI04)

Originator: NCI Thesaurus | Source: The website of the National Cancer Institute (http://www.cancer.gov)

How to use Amal suppositories

  1. Remove the suppository from the wrapping.
  2. You may find that inserting the suppository is easier if you squat or bend forward.
  3. Using a finger, gently push the suppository into your back passage (rectum).
  4. Remove your finger and then remain still for a little while to help you hold the suppository in place.
  5. Then, wash your hands.

Can Amal cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the more common ones associated with Amal. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.

Can taking Amal during pregnancy cause birth defects?

Probably not. Most studies have found no increased chance for birth defects among thousands of women who used Amal in the first trimester. However, one study reported an association with cleft palate. This study used interviews with the mothers to learn about the medications taken during pregnancy. This study found a small increased chance for cleft palate (an opening in the roof of the mouth that may be repaired with surgery). Two other studies reported an association with heart defects.

Zofran Interactions

Some drugs may affect the way Zofran works, and Amal may affect other drugs you are taking.

It's very important to let your doctor know about all drugs you are taking, including over-the-counter medications as well as any herbs or supplements.

Drugs that are known to interact with Zofran and may cause problems include:

  • Apomorphine
  • Other serotonin 5-HT3 antagonists, including Lotronex, Anzemet, Kytril, and Aloxi
  • Some antibiotics, such as clarithromycin (Biaxin, in Prevpac) and erythromycin (E.E.S., Erythrocin)
  • Medications to treat irregular heartbeat, such as amiodarone (Cordarone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn) and others
  • Beta blockers, or drugs used to slow the heart rate, such as acebutolol (Sectral), atenolol (Tenormin), bisoprolol (Zebeta) and others
  • The pain medicine tramadol (Ultram, in Ultracet)
  • Some antiseizure medications, such as phenytoin (Dilantin)
  • Some antipsychotic medications, including thioridazine (Mellaril), haloperidol (Haldol), and mesoridazine (Serentil)
  • Some drugs used to treat depression, including venlafaxine (Effexor) and amitriptyline (Elavil)

Amal special precautions

Before taking Amal:

  • tell your doctor and pharmacist if you are allergic to Amal, alosetron (Lotronex), dolasetron (Anzemet), granisetron (Kytril), palonosetron (Aloxi, in Akynzeo), any other medications, or any of the ingredients in Amal tablets or liqu >Amal while pregnant

Amal has also been prescribed during pregnancy to reduce symptoms of nausea and vomiting in pregnancy. Nausea and vomiting in pregnancy is also referred to as “morning sickness”. Amal is sold under the brand name Zofran ® .

Nausea and vomiting in pregnancy or “morning sickness” is the most common medical condition in pregnancy. It affects 50-80% of pregnant women. Nausea and vomiting in pregnancy symptoms can range from mild to severe. The symptoms can happen at any time during the day or at night. Symptoms can include nausea, dry heaves, retching and/or vomiting. Nausea and vomiting in pregnancy usually begins between 4-9 weeks of pregnancy, and peaks between 7-12 weeks. In most women, symptoms go away between 12-16 weeks of pregnancy. Up to 15% of women will continue to have symptoms up to 20 weeks of pregnancy or until delivery.

The most severe form of nausea and vomiting in pregnancy is known as hyperemesis gravidarum, which affects up to 3% of pregnant women. Hyperemesis gravidarum is when there is severe nausea and constant vomiting that causes weight loss and dehydration (not getting enough water). Women with hyperemesis gravidarum can require hospitalization.

Whether symptoms of nausea and vomiting in pregnancy are mild, moderate or severe, it can have a major impact on a woman’s quality of life. If nausea and vomiting in pregnancy is affecting your ability to eat, sleep and perform your daily activities, speak with your healthcare provider. If the symptoms of nausea and vomiting in pregnancy first start at the 10th week of pregnancy or later they may be due to other causes and should be discussed with your healthcare provider.

Eating small meals often, drinking plenty of clear fluids, and avoiding triggers (such as odors, heat, and spicy or high fat foods) can help control nausea and vomiting during pregnancy.

What Is Zofran (Amal)?

Zofran is a brand name for the drug Amal, prescribed to treat or prevent nausea and vomiting.

Doctors sometimes prescribe Zofran to treat nausea and vomiting caused by cancer treatments such as chemotherapy and radiation therapy.

Zofran also can treat nausea and vomiting after surgery.

The drug may also help prevent the common complication of shivering in people who have had anesthesia.

Some doctors have prescribed Zofran off-label to treat nausea and vomiting caused by morning sickness in pregnant women, though the drug has never been approved for this use.

Zofran blocks serotonin, a natural substance in the brain that may contribute to nausea and vomiting.

It belongs to a class of drugs called serotonin 5-HT3 receptor antagonists. These drugs are antiemetics, meaning they block nausea and vomiting.

The Food and Drug Administration (FDA) approved Amal in 1992 under the brand name Zofran for GlaxoSmithKline.

In 2007, the FDA approved generic Amal for several drug companies.


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