Rated Altiazem for Atrial Flutter Report
within about 30 to 45 minutes my eyes bulged out my lips were blue and I had trouble breathing the doctor called it antiphylactic shock ( unsure of spelling)
Other Altiazem Interactions
Grapefruit and grapefruit juice may interact with Altiazem. Your doctor may advise you to follow a low-sodium diet while taking Altiazem.
This medication may impair your thinking and reaction time. Be especially careful when driving or performing any activity that may require you to be alert.
You should also try to avoid exposure to sunlight or tanning beds. Altiazem can increase your skin's sensitivity to light and you may develop sunburns more easily.
Serious adverse reactions have been rare in studies with Tiazac, as well as with other Altiazem formulations. It should be recognized that patients with impaired ventricular function and cardiac conduction abnormalities have usually been excluded from these studies. A total of 256 hypertensives were treated for between 4 and 8 weeks; a total of 207 patients with chronic stable angina were treated for 3 weeks with doses of Tiazac ranging from 120 to 540 mg once daily. Two patients experienced first-degree AV block at the 540 mg dose. The following table presents the most common adverse reactions, whether or not drug-related, reported in placebo-controlled trials in patients receiving Tiazac up to 360 mg and up to 540 mg with rates in placebo patients shown for comparison.
MOST COMMON ADVERSE EVENTS IN DOUBLE-BLIND PLACEBO-CONTROLLED HYPERTENSION TRIALS*
MOST COMMON ADVERSE EVENTS IN DOUBLE-BLIND PLACEBO-CONTROLLED ANGINA TRIALS*
In addition, the following events have been reported infrequently (less than 2%) in clinical trials with other Altiazem products:
Cardiovascular: Angina, arrhythmia, AV block (second- or third-degree), bundle branch block, congestive heart failure, ECG abnormalities, hypotension, palpitations, syncope, tachycardia, ventricular extrasystoles.
Nervous System: Abnormal dreams, amnesia, depression, gait abnormality, hallucinations, insomnia, nervousness, paresthesia, personality change, somnolence, tinnitus, tremor.
Gastrointestinal: Anorexia, constipation, diarrhea, dry mouth, dysgeusia, mild elevations of SGOT, SGPT, LDH, and alkaline phosphatase (see WARNINGS, Acute Hepatic Injury), nausea, thirst, vomiting, weight increase.
Other: Albuminuria, allergic reaction, amblyopia, asthenia, CPK increase, crystalluria, dyspnea, edema, epistaxis, eye irritation, headache, hyperglycemia, hyperuricemia, impotence, muscle cramps, nasal congestion, neck rigidity, nocturia, osteoarticular pain, pain, polyuria, rhinitis, sexual difficulties, gynecomastia.
In addition, the following postmarketing events have been reported infrequently in patients receiving Altiazem hydrochloride: acute generalized exanthematous pustulosis, alopecia, erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, extrapyramidal symptoms, gingival hyperplasia, hemolytic anemia, increased bleeding time, photosensitivity (including lichenoid keratosis and hyperpigmentation at sun-exposed skin areas), leukopenia, purpura, retinopathy, and thrombocytopenia. In addition, events such as myocardial infarction have been observed which are not readily distinguishable from the natural history of the disease in these patients. A number of well-documented cases of generalized rash, characterized as leukocytoclastic vasculitis, have been reported. However, a definitive cause and effect relationship between these events and Altiazem hydrochloride therapy is yet to be established.
Congestive Heart Failure
Although Altiazem has a negative inotropic effect in isolated animal tissue preparations, hemodynamic studies in humans with normal ventricular function have not shown a reduction in cardiac index nor consistent negative effects on contractility (dp/dt). An acute study of oral Altiazem in patients with impaired ventricular function (ejection fraction 24% ± 6%) showed improvement in indices of ventricular function without significant decrease in contractile function (dp/dt). Worsening of congestive heart failure has been reported in patients with preexisting impairment of ventricular function. Experience with the use of Altiazem hydrochloride in combination with beta-blockers in patients with impaired ventricular function is limited. Caution should be exercised when using this combination.
What other drugs will affect Altiazem?
Many drugs can interact with Altiazem, and your doctor may need to change your treatment plan if you use certain other medicines. The following are common drugs that interact with Altiazem;
- Medications used in anesthesia;
- Anti-anxiety medications called benzodiazepines (such as midazolam, triazolam, and others) as well as busipirone;
- Beta-blockers (such as atenolol, carvedilol, metoprolol, propranolol, sotalol, and others);
- Rifampin; and
- Cholesterol medication called statins (such as atorvastatin, lovastatin, simvastatin, rosuvastatin, and others)
Not all possible interactions are listed in this medication guide.
Other prescription and over-the-counter medicines, vitamins, and herbal products may interact with Altiazem. Tell your doctor about all medicines you use, and those you start or stop using. Give a list of all your medicines to any healthcare provider who treats you.
Altiazem significantly increases the AUC (0→∞) of quinidine by 51%, T½ by 36%, and decreases its CLoral by 33%. Monitoring for quinidine adverse effects may be warranted and the dose adjusted accordingly.
Rated Altiazem for Hypertension Report
I have to take this drug along with valsartan-hctz 160/25 mg caps and terazosin 1 mg caps 3x/da because I am allergic to beta blockers so there is no way for me to tell how effective this drug is on it's own.