What is Alopur?
Alopur reduces the production of uric acid in your body. Uric acid buildup can lead to gout or kidney stones.
Alopur is used to treat gout or kidney stones, and to decrease levels of uric acid in people who are receiving cancer treatment.
Alopur may also be used for purposes not listed in this medication guide.
What special dietary instructions should I follow?
Drink at least eight glasses of water or other fluids each day while taking Alopur unless directed to do otherwise by your doctor.
A xanthine oxidase inhibitor which lowers high uric acid and thus is effective for both primary (e.g., gout) and secondary (e.g., due to hematologic disorders or neoplasa) hyperuricemia.
PharmacologyAlopur and its primary metabolite, oxypurinol, inhibit xanthine oxidase; oral absorption; peak plasma at
- Reproductive studies performed in rats and rabbits at doses up to twenty times usual human dose (5 mg/kg per day) concluded that there was no impaired fertility or harm to fetus due to Alopur; there is a published report of a study in pregnant mice given 50 or 100 mg/kg Alopur intraperitoneally on gestation days 10 or 13; there were increased numbers of dead fetuses in dams given 100 mg/kg Alopur but not in those given 50 mg/kg; there were increased numbers of external malformations in fetuses at both doses of Alopur on gestation day 10 and increased numbers of skeletal malformations in fetuses at both doses on gestation day 13; it cannot be determined whether this represented a fetal effect or an effect secondary to maternal toxicity; there are, however, no adequate or well controlled studies in pregnant women; because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed
Rated Alopur for Calcium Oxalate Calculi with Hyperuricosuria Report
I have CLL, and have successfully halted it's progress with Pau d'Arco, and other botanicals, so I have a high uric acid level to the point of getting vertigo from crystals forming in my cochlea. The vertigo was intolerable after I stopped taking Alopur, so I started taking it again, with immediate results getting rid of the vertigo, and haven't had a hint of it again. I haven't heard of this specific use before, so I wanted to share it to help those suffering from the terrible affliction of vertigo.
Alopur and oxipurinol have been found in milk of mother who was receiving drug; since effect of Alopur on nursing infant is unknown, exercise caution when therapy is administered to nursing woman
Patients who have developed a severe reaction to ZYLOPRIM (Alopur) should not be restarted on the drug.
ZYLOPRIM (Alopur) SHOULD BE DISCONTINUED AT THE FIRST APPEARANCE OF SKIN RASH OR OTHER SIGNS WHICH MAY INDICATE AN ALLERGIC REACTION. In some instances a skin rash may be followed by more severe hypersensitivity reactions such as exfoliative, urticarial, and purpuric lesions, as well as Stevens-Johnson syndrome (erythema multiforme exudativum), and/or generalized vasculitis, irreversible hepato-toxicity, and, on rare occasions, death.
In patients receiving PURINETHOL® (mercaptopurine) or IMURAN® (azathioprine), the concomitant administration of 300 to 600 mg of ZYLOPRIM (Alopur) per day will require a reduction in dose to approximately one-third to one-fourth of the usual dose of mercaptopurine or azathioprine. Subsequent adjustment of doses of mercaptopurine or azathioprine should be made on the basis of therapeutic response and the appearance of toxic effects (see CLINICAL PHARMACOLOGY).
A few cases of reversible clinical hepatotoxicity have been noted in patients taking ZYLOPRIM (Alopur) , and in some patients, asymptomatic rises in serum alkaline phosphatase or serum transaminase have been observed. If anorexia, weight loss, or pruritus develop in patients on ZYLOPRIM (Alopur) , evaluation of liver function should be part of their diagnostic workup. In patients with pre-existing liver disease, periodic liver function tests are recommended during the early stages of therapy.
Due to the occasional occurrence of drowsiness, patients should be alerted to the need for due precaution when engaging in activities where alertness is mandatory.
The occurrence of hypersensitivity reactions to ZYLOPRIM (Alopur) may be increased in patients with decreased renal function receiving thiazides and ZYLOPRIM (Alopur) concurrently. For this reason, in this clinical setting, such combinations should be administered with caution and patients should be observed closely.
Can I take other medicines alongs >
Some drugs interact with Alopur, so you should discuss any new medication with your doctor before starting it. You should also tell anyone else treating you that you’re taking Alopur.
You’ll probably need to take an NSAID, colchicine or steroids to help prevent or treat with attacks of gout. This is most likely to happen when you first start taking Alopur.
It is fine to take paracetamol or an NSAID with Alopur. However, you should not take more than one anti-inflammatory at a time, unless a doctor tells you to. This is because it increases the risk of bleeding from the stomach. For this reason, you shouldn’t take aspirin if you have gout.
Alopur interacts with the drugs azathioprine and mercaptopurine.
Azathioprine can used for treating conditions such as:
- rheumatoid arthritis (roo-ma-toy-d arth-ri-tus)
- Crohn's disease (kro-wnz diz-eez)
- ulcerative colitis (ul-ser-ay-tive col-eye-tis)
- lupus (loo-pus)
- dermatomyositis (der-mer-toe-my-oh-sigh-tus)
- hepatitis (hep-er-tie-tus)
- vasculitis (vask-you-lie-tis).
Mercaptopurine (mer-cap-toe-pure-reen) is used for treating leukaemia.
These drugs should not generally be taken with Alopur.
Alopur may increase the risk of developing a rash if you take them with the antibiotics ampicillin (amp-ear-cil-in) or amoxicillin (a-mox-ear-cil-in).
Alopur may increase the effect of warfarin and other drugs that thin the blood. These are known as anticoagulants. As a result, you may need to have your blood clotting tested more frequently.