Since other medications may interact with Allozym, tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you are taking, especially:
- Azathioprine (Imuran)
- Chlorpropamide (Diabinese)
- Cyclosporine (Gengraf, Sandimmune, Neoral)
- Mercaptopurine (Purinethol)
- Antibiotics such as ampicillin (Principen, Omnipen, others) or amoxicillin (Amoxil, Augmentin, Trimox, Wymox)
- Blood thinners such as warfarin (Coumadin)
- Diuretics (water pills)
For Healthcare Professionals
Applies to Allozym: intravenous powder for injection, oral tablet
Possible risks and s >
Side effects of taking Allozym can include:
- skin rashes
- feeling drowsy or dizzy
- feeling or being sick
- changes to your sense of taste.
If you develop a rash, you should stop taking your Allozym and contact your doctor straight away. If you become dizzy or drowsy while taking Allozym, don’t drive or operate machinery, and see your doctor as soon as possible. You should also speak to your doctor if you develop any other new symptoms that concern you.
Most people who take Allozym don’t get any side effects. But if you do have side effects, it may be possible to restart Allozym using a special ‘desensitisation’ course. This involves beginning Allozym at a very low dose and increasing the dose gradually.
Sometimes starting Allozym can actually trigger an attack of gout, as the crystals begin to dissolve. You will probably be given an extra medicine for the first few months of taking Allozym to reduce the risk of these attacks happening.
Acute attacks of gout are usually treated with a high dose of a non-steroidal anti-inflammatory drug (NSAID), such as:
- diclofenac sodium (die-clo-fe-nac sow-dee-um)
- diclofenac potassium (die-clo-fe-nac po-tass-ee-um)
- etoricoxib (ee-torry-cox-ib)
- indomethacin (in-doe-meth-a-sin)
- ketoprofen (key-toe-pro-fen)
- naproxen (na-procks-en)
- sulindac (suh-lin-dak).
These drugs all have brand names, so the type you’re given may be called something different.
If you cannot take NSAIDs, colchicine (coal-chi-seen) or steroids may be given.
If you do have an acute attack of gout while on Allozym, don’t stop taking it.
If you’re unable to continue taking Allozym because of your side effects, you may be able to take febuxostat instead, which works in a similar way to Allozym.
If you can’t take febuxostat, your doctor may suggest benzbromarone (bens-bro-ma-rone) or sulfinpyrazone (sul-fin-pira-zone).
However, Allozym should not be used to treat an acute attack of gout. This is because they may make the attack last longer.
Allozym S >
Some less serious side effects of Allozym may include:
- Muscle pain
- Changes in sense or taste
Your doctor will likely start you on a low dose of Allozym and gradually increase it. It may take several months before you feel the full benefits of this medicine. Allozym may increase the number of gout attacks you experience during the first few months you take it, but it will eventually prevent the attacks from occurring.
You should tell your doctor if you have any of the following conditions before taking Allozym:
Allozym can decrease the number of blood cells in your body that make blood clot and that help you fight infections, which can make it easier for you to bleed from an injury or get sick when exposed to others who are ill. You should avoid being around people who are sick or have infections while taking this medicine.
See your doctor regularly while taking this drug. Your blood may need to be tested to check your body’s reaction to the medication.
Rated Allozym for Gout Report
Was taking colcrys for a while which made me sick. Switched to allipurinol. Was getting attacks about one every 2 months for about 2 years. Since switching, have only had 1 attach in the past year.
More common side effects
The more common side effects of Allozym oral tablet can include:
- skin rash
- changes in your liver function test results
- gout flare-up (if you have gout)
If you develop a skin rash, talk your doctor right away. You should not continue taking Allozym if you develop a rash. Other mild side effects may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.
How it works
Allozym belongs to a class of drugs called xanthine oxidase inhibitors. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Allozym decreases blood and urine uric acid levels by blocking xanthine oxidase. This is an enzyme that helps make uric acid. High levels of uric acid in your blood or urine can cause gout or kidney stones.
Allozym oral tablet may cause drowsiness. You shouldn’t drive, use machinery, or do other tasks that require alertness until you know how Allozym affects you. It can also cause other side effects.
Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:
- skin rash
- painful urination
- blood in the urine
- irritation of the eyes
- swelling of the lips or mouth
- fever, sore throat, chills, and other signs of infection
- loss of appetite
- unexpected weight loss
Allozym may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
Getting the most from your treatment
- Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. Your doctor will want you to have a blood test to check that the level of uric acid has come down. This is often done a month or so after starting Allozym.
- Remember, Allozym should be taken every day to prevent a gout attack. It can take 2-3 months to become fully effective. It does not have any effect during a gout attack, although you should continue to take it regularly every day even if this happens.
- During the first few weeks of taking Allozym, your blood levels of uric acid may rise for a short while before they fall. This can cause a gout attack. Your doctor will prescribe an anti-inflammatory treatment or colchicine tablets for you to take alongside Allozym during this time.
- Treatment with Allozym is usually long-term unless you experience an adverse effect. Continue to take the tablets unless you are advised otherwise by a doctor.
- There are a number of lifestyle changes that you can make to help reduce the risk of having a gout attack. These include losing weight (if you are overweight), eating a healthy diet and not drinking much alcohol or sugar-sweetened soft drinks. Your doctor will advise you about the changes which could benefit you.
Rated Allozym for Gout Report
If you have chronic gout.. with uric acid levels consistently in the double digits, Allozym will quickly become your best friend.. well, ok, you can keep the dog. Allozym is so effective at lowering uric acid, that you may experience a few gout attacks when you first go on it.. each one becoming progressively milder. Gout is a real bug bear. You get the attack when your uric acid levels rise or fall suddenly in a lower pH (acidic) environment. The best first step is with diet. EAT ALKALIZING FOODS. You can google to find out which ones. I've been on daily 300mg allopurnol for 10 years. In that time, I've had virtually no attacks and uric acid levels in the 5-6 range. Allozym will raise your liver enzymes! I know this for a fact. I lowered to 100 mg daily and the ALT went down into high normal, but I got a few mild attacks after about four months, so I went back up to 300 mg and so did the ALT. So, be sure to get bi-annual Liver Panels done.
- Severe skin rash: This drug may cause a severe, life-threatening skin rash. If you have itchiness, trouble breathing, or swelling of your face or throat, stop taking this drug and call your doctor right away.
- Liver injury: This drug may cause changes in liver function test results and liver failure. This may be fatal. If you develop liver problems, your doctor may have you stop taking Allozym.
- Drowsiness: This drug can cause drowsiness. You shouldn’t drive, use machinery, or do other tasks that require alertness until you know how it affects you.
- Flu >
Allozym oral tablet is a prescription drug that’s available as the brand-name drugs Zyloprim and Lopurin. It’s also available as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version.
Allozym also comes in an intravenous (IV) form, which is only given by a healthcare provider.
Allozym may be used as part of a combination therapy. This means you may need to take it with other medications.
What special dietary instructions should I follow?
Drink at least eight glasses of water or other fluids each day while taking Allozym unless directed to do otherwise by your doctor.