1. "Product Information. Zyloprim capsules (Allopur)." Glaxo Wellcome, Research Triangle Park, NC.
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. Cerner Multum, Inc. "Australian Product Information." O 0
Allopur may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- upset stomach
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Allopur is the most commonly prescribed drug for the prevention of recurring gout attacks. It comes under the class of drugs called xanthine oxidase (XO) inhibitors. XO helps to convert purines into uric acid. So if this reaction can be prevented or slowed down (e.g. by taking Allopur) then less uric acid will be produced and blood uric acid levels will fall.
The problem with the drug is that it only works while it’s being taken. Once stopped, the inhibition of XO also stops, so your uric acid levels can rise again, which is why Allopur is usually taken for life.
Allopur is generally started between 2 and 3 weeks after a gout attack has abated. The recommended dosage is between 100mg and 300mg per day usually in one oral dose. But for some people higher doses of up to 800mg per day may be required initially.
And it may take some months before your doctor arrives at the correct dosage for your particular case; perhaps starting off with 1 x 100mg tablet per day. The objective is to get your blood uric acid down, and stable, below 6mg/dl.
When taking Allopur for the first time you may experience a gout flare. But don’t be alarmed, this happens in around 75% of cases, so you won’t be alone.
The flare happens because there is a relatively fast reduction in blood uric ac >synovial membrane .
When this happens don’t stop taking your Allopur…
Why is this medication prescribed?
Allopur is used to treat gout, high levels of uric acid in the body caused by certain cancer medications, and kidney stones. Allopur is in a class of medications called xanthine oxidase inhibitors. It works by reducing the production of uric acid in the body. High levels of uric acid may cause gout attacks or kidney stones. Allopur is used to prevent gout attacks, not to treat them once they occur.
Can I take other medicines alongs >
Some drugs interact with Allopur, so you should discuss any new medication with your doctor before starting it. You should also tell anyone else treating you that you’re taking Allopur.
You’ll probably need to take an NSAID, colchicine or steroids to help prevent or treat with attacks of gout. This is most likely to happen when you first start taking Allopur.
It is fine to take paracetamol or an NSAID with Allopur. However, you should not take more than one anti-inflammatory at a time, unless a doctor tells you to. This is because it increases the risk of bleeding from the stomach. For this reason, you shouldn’t take aspirin if you have gout.
Allopur interacts with the drugs azathioprine and mercaptopurine.
Azathioprine can used for treating conditions such as:
- rheumatoid arthritis (roo-ma-toy-d arth-ri-tus)
- Crohn's disease (kro-wnz diz-eez)
- ulcerative colitis (ul-ser-ay-tive col-eye-tis)
- lupus (loo-pus)
- dermatomyositis (der-mer-toe-my-oh-sigh-tus)
- hepatitis (hep-er-tie-tus)
- vasculitis (vask-you-lie-tis).
Mercaptopurine (mer-cap-toe-pure-reen) is used for treating leukaemia.
These drugs should not generally be taken with Allopur.
Allopur may increase the risk of developing a rash if you take them with the antibiotics ampicillin (amp-ear-cil-in) or amoxicillin (a-mox-ear-cil-in).
Allopur may increase the effect of warfarin and other drugs that thin the blood. These are known as anticoagulants. As a result, you may need to have your blood clotting tested more frequently.
Before taking Allopur
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking Allopur it is important that your doctor knows:
- If you are pregnant or breastfeeding.
- If you have any problems with the way your liver works, or any problems with the way your k >
What is Allopur and how is it used?
Allopur (al-oh-pure-ri-nol) is mainly used for the long-term treatment and prevention of gout. Taken regularly, it can stop attacks of gout and help prevent damage to your joints.
It can also be used for treating kidney stones.
The body naturally produces a substance called urate. This normally dissolves in your blood until it’s passed out of the body in your urine. When too much urate is produced, or if your body can’t get rid of it properly, crystals can form in and around your joints. This causes pain and inflammation.
Allopur blocks an enzyme that is involved in producing urate. This helps the crystals to dissolve and stops attacks of gout.
Allopur can lower the urate levels in your blood over the space of a few weeks. This will stop new crystals forming.
It can take longer to dissolve crystals that are already there, and you may have more attacks of gout during this time. This is more likely to happen if your urate levels are very high or you’ve had gout for a long time. If this happens to you, it doesn’t mean that your Allopur isn’t working.
Attacks of gout usually stop within a year, as long as your urate level has gone down enough.
Your doctor will usually be cautious about prescribing Allopur if you have kidney, thyroid or liver problems.
You will usually be offered Allopur for gout if blood tests show that your urate level is high and one or more of the following applies:
- You keep having attacks of gout.
- Your joints or kidneys have been damaged by attacks of gout.
- Your skin has been affected by deposits of urate crystals.
Should I Avoid Any Food, Drink or Activity While Taking Allopur?
Avoid drinking alcohol while taking Allopur, as it may make your condition worse. Allopur may impair your thinking or reaction time, so you should be especially careful when driving or performing any activity that requires you to be alert.
Your doctor may advise you to follow a special diet to help treat your condition.