Alloprim tablets


  • Active Ingredient: Allopurinol
  • 300 mg
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What is Alloprim?

The active ingredient of Alloprim brand is allopurinol. Allopurinol reduces the production of uric acid in your body. Uric acid buildup can lead to gout or kidney stones. Allopurinol is known chemically as 1,5-dihydro-4H-pyrazolo [3,4-d]pyrimidin-4-one. It is a xanthine oxidase inhibitor which is administered orally. Each scored white tablet contains 100 mg Allopurinol and the inactive ingredients colloidal silicon dioxide, lactose monohydrate, magnesium stearate, microcrystalline cellulose and sodium starch glycolate. Each scored orange tablet contains 300 mg Allopurinol and the inactive ingredients colloidal silicon dioxide, FD&C Yellow No. 6 Lake, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and sodium starch glycolate. Its solubility in water at 37В°C is 80 mg/dL and is greater in an alkaline solution.

Used for

Alloprim is used to treat diseases such as: Calcium Oxalate Calculi with Hyperuricosuria, Cardiothoracic Surgery, Gout, Heart Failure, High Risk Percutaneous Transluminal Angioplasty, Hyperuricemia Secondary to Chemotherapy, Leishmaniasis, Mania, Reactive Perforating Collangenosis, Urinary Tract Stones.

Side Effect

Possible side effects of Alloprim include: slow or irregular heartbeat; multiple swollen and inflamed skin lesions; sensitivity to light; depression; incoherent speech.

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Rated Alloprim for Gout Report

Was taking colcrys for a while which made me sick. Switched to allipurinol. Was getting attacks about one every 2 months for about 2 years. Since switching, have only had 1 attach in the past year.

Missed Dose of Alloprim

If you miss a dose of Alloprim, take it as soon as you remember. Skip the missed dose if it is almost time for your next, scheduled dose. Do not take extra medicine to make up for the missed dose.

Can I take other medicines alongs >

Some drugs interact with Alloprim, so you should discuss any new medication with your doctor before starting it. You should also tell anyone else treating you that you’re taking Alloprim.

You’ll probably need to take an NSAID, colchicine or steroids to help prevent or treat with attacks of gout. This is most likely to happen when you first start taking Alloprim.

It is fine to take paracetamol or an NSAID with Alloprim. However, you should not take more than one anti-inflammatory at a time, unless a doctor tells you to. This is because it increases the risk of bleeding from the stomach. For this reason, you shouldn’t take aspirin if you have gout.

Alloprim interacts with the drugs azathioprine and mercaptopurine.

Azathioprine can used for treating conditions such as:

  • rheumatoid arthritis (roo-ma-toy-d arth-ri-tus)
  • Crohn's disease (kro-wnz diz-eez)
  • ulcerative colitis (ul-ser-ay-tive col-eye-tis)
  • lupus (loo-pus)
  • dermatomyositis (der-mer-toe-my-oh-sigh-tus)
  • hepatitis (hep-er-tie-tus)
  • vasculitis (vask-you-lie-tis).

Mercaptopurine (mer-cap-toe-pure-reen) is used for treating leukaemia.

These drugs should not generally be taken with Alloprim.

Alloprim may increase the risk of developing a rash if you take them with the antibiotics ampicillin (amp-ear-cil-in) or amoxicillin (a-mox-ear-cil-in).

Alloprim may increase the effect of warfarin and other drugs that thin the blood. These are known as anticoagulants. As a result, you may need to have your blood clotting tested more frequently.

What is Alloprim and how is it used?

Alloprim (al-oh-pure-ri-nol) is mainly used for the long-term treatment and prevention of gout. Taken regularly, it can stop attacks of gout and help prevent damage to your joints.

It can also be used for treating kidney stones.

The body naturally produces a substance called urate. This normally dissolves in your blood until it’s passed out of the body in your urine. When too much urate is produced, or if your body can’t get rid of it properly, crystals can form in and around your joints. This causes pain and inflammation.

Alloprim blocks an enzyme that is involved in producing urate. This helps the crystals to dissolve and stops attacks of gout.

Alloprim can lower the urate levels in your blood over the space of a few weeks. This will stop new crystals forming.

It can take longer to dissolve crystals that are already there, and you may have more attacks of gout during this time. This is more likely to happen if your urate levels are very high or you’ve had gout for a long time. If this happens to you, it doesn’t mean that your Alloprim isn’t working.

Attacks of gout usually stop within a year, as long as your urate level has gone down enough.

Your doctor will usually be cautious about prescribing Alloprim if you have kidney, thyroid or liver problems.

You will usually be offered Alloprim for gout if blood tests show that your urate level is high and one or more of the following applies:

  • You keep having attacks of gout.
  • Your joints or kidneys have been damaged by attacks of gout.
  • Your skin has been affected by deposits of urate crystals.

Alloprim Interactions

Since other medications may interact with Alloprim, tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you are taking, especially:

  • Azathioprine (Imuran)
  • Chlorpropamide (Diabinese)
  • Cyclosporine (Gengraf, Sandimmune, Neoral)
  • Mercaptopurine (Purinethol)
  • Antibiotics such as ampicillin (Principen, Omnipen, others) or amoxicillin (Amoxil, Augmentin, Trimox, Wymox)
  • Blood thinners such as warfarin (Coumadin)
  • Diuretics (water pills)


Patients who have developed a severe reaction to ZYLOPRIM (Alloprim) should not be restarted on the drug.

Serious Side Effects of Alloprim

Call your doctor immediately if you experience any of the following serious side effects:

  • Fever, sore throat, and headache with a severe blistering, peeling and red skin rash
  • Any sign of skin rash, no matter how mild
  • Nausea, upper stomach pain, itching, loss of appetite, weight loss, dark urine, clay-colored stools, jaundice
  • Pain or bleeding when urinating
  • Urinating less frequently or not at all
  • Joint pain or flu symptoms
  • Easy bruising, unusual bleeding, or purple or red pinpoint spots under the skin
  • Severe tingling, numbness, pain, or muscle weakness

More common side effects

The more common side effects of Alloprim oral tablet can include:

  • skin rash
  • diarrhea
  • nausea
  • changes in your liver function test results
  • gout flare-up (if you have gout)

If you develop a skin rash, talk your doctor right away. You should not continue taking Alloprim if you develop a rash. Other mild side effects may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

How should I take Alloprim?

Take Alloprim exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Take each dose with a full glass of water. To reduce your risk of kidney stones forming, drink 8 to 10 full glasses of fluid every day, unless your doctor tells you otherwise.

Take with food if Alloprim upsets your stomach.

You may have gout attacks more often when you first start taking Alloprim. Your doctor may recommend other gout medication to take at this time. Keep using your medication as directed and tell your doctor if your symptoms do not improve after 6 weeks of treatment.

You may need to follow a special diet while using Alloprim. Follow all instructions of your doctor or dietitian. Learn about the foods to eat or avoid to help control your condition.

Store at room temperature away from moisture and heat.

Q: My last uric acid level was 7.5. Will Alloprim bring down uric acid levels?

A: Alloprim (Zyloprim) is a xanthine oxidase inhibitor that reduces the production of uric acid in your body. A uric acid buildup can lead to gout or kidney stones. Alloprim is used to treat gout. Common side effects of Alloprim include nausea, vomiting, diarrhea, dizziness, and joint pain. According to the prescribing information, Alloprim administration usually results in a decrease of uric acid within 2 to 3 days. However, it may take 1 week or more to see the full benefits. This is not a complete list of side effects associated with Alloprim, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Kimberly Hotz, PharmD

By Julie Marks | Medically Reviewed by Mona Khanna, MD

Latest Update: 2014-10-20 Copyright © 2014 Everyday Health Media, LLC


Chronic therapy with Alloprim is associated with transient and minor liver test abnormalities in 2% to 6% of patients, which resolve spontaneously or with drug discontinuation. More importantly, Alloprim has been linked to acute liver injury that is typically associated with immunoallergic manifestations such as fever, rash, eosinophilia, lymphadenopathy, lymphocytosis, arthralgias and facial edema (drug-rash, eosinophilia and systemic symptoms — DRESS syndrome) (Case 1). The typical latency to onset is 2 to 6 weeks and the pattern of liver enzyme elevations tends to be hepatocellular or mixed, but can be cholestatic. Autoantibodies are not common. Alloprim hepatotoxicity has a high fatality rate, either from acute liver failure or complications of other allergic manifestations such as toxic epidermal necrolysis, vasculitis, pancreatitis and renal dysfunction. African-American race and preexisting renal disease appear to be risk factors for hypersensitivity to Alloprim.

Likelihood score: A (well established cause of clinically apparent liver injury).

Liver biopsy in Alloprim hepatotoxicity typically shows an acute cholestatic or mixed hepatitis. Bile duct injury may be prominent early and loss of bile ducts later during the course. Histology can also show granulomas including "ring" granulomas that are typically associated with visceral infections such as Q fever or Kala-azar. Granulomas may be found in other organs as well and represent a typical histological correlate to the immunoallergic response to a medication. Two examples of Alloprim hepatotoxicity are shown: one with a cholestatic hepatitis and another with acute granulomatous changes.


  • Hypersensitivity to Alloprim
  • This medication contains Alloprim. Do not take Zyloprim or Aloprim if you are allergic to Alloprim or any ingredients contained in this drug
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately

What Is Alloprim (Zyloprim)?

Zyloprim is the brand name of the drug Alloprim, which is used to treat gout, high levels of uric acid in the body (often caused by certain cancers and cancer treatments), and kidney stones.

The medication may also be used to treat seizures, infections, and pain caused by pancreas disease. It is sometimes used to improve survival after bypass surgery, prevent rejection of kidney transplants, or reduce ulcer relapses.

Alloprim is a type of medication called a xanthine oxidase inhibitor. It works by reducing the production of uric acid in the body. It comes in the form of an oral tablet.

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