Allobeta tablets

Allobeta

  • Active Ingredient: Allopurinol
  • 300 mg
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What is Allobeta?

The active ingredient of Allobeta brand is allopurinol. Allopurinol reduces the production of uric acid in your body. Uric acid buildup can lead to gout or kidney stones. Allopurinol is known chemically as 1,5-dihydro-4H-pyrazolo [3,4-d]pyrimidin-4-one. It is a xanthine oxidase inhibitor which is administered orally. Each scored white tablet contains 100 mg Allopurinol and the inactive ingredients colloidal silicon dioxide, lactose monohydrate, magnesium stearate, microcrystalline cellulose and sodium starch glycolate. Each scored orange tablet contains 300 mg Allopurinol and the inactive ingredients colloidal silicon dioxide, FD&C Yellow No. 6 Lake, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and sodium starch glycolate. Its solubility in water at 37В°C is 80 mg/dL and is greater in an alkaline solution.

Used for

Allobeta is used to treat diseases such as: Calcium Oxalate Calculi with Hyperuricosuria, Cardiothoracic Surgery, Gout, Heart Failure, High Risk Percutaneous Transluminal Angioplasty, Hyperuricemia Secondary to Chemotherapy, Leishmaniasis, Mania, Reactive Perforating Collangenosis, Urinary Tract Stones.

Side Effect

Possible side effects of Allobeta include: Abdominal or stomach pain; indigestion; muscle weakness; blood in the urine or stools; runny nose; Ankle, knee, or great toe joint pain.

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Rated Allobeta for Gout Report

Was taking colcrys for a while which made me sick. Switched to allipurinol. Was getting attacks about one every 2 months for about 2 years. Since switching, have only had 1 attach in the past year.

Interactions

Drug-drug. Amoxicillin, ampicillin, bacampicillin: increased risk of rash

Anticoagulants (except warfarin): increased anticoagulant effect

Antineoplastics: increased risk of myelosuppression

Azathioprine, mercaptopurine: inhibition of Allobeta metabolism

Chlorpropamide: increased hypoglycemic effects

Diazoxide, diuretics, mecamylamine, pyrazinamide: increased uric acid levels

Ethacrynic acid, thiazide diuretics: increased risk of Allobeta toxicity

Uricosurics: increased uric acid excretion

Urine-acidifying drugs (ammonium chloride, ascorbic acid, potassium or sodium phosphate): increased risk of renal calculi

Xanthines: increased theophylline levels

Drug-diagnostic tests. Alanine aminotransferase, alanine phosphatase, aspartate aminotransferase, bilirubin, eosinophils: increased levels

Granulocytes, hemoglobin, platelets, white blood cells: decreased levels

Drug-food. Caffeine-containing beverages and foods, mineral water, orange juice: decreased drug absorption, increased uric acid level

Drug-behaviors. Alcohol use: increased uric acid level

Rated Allobeta for Hyperuricemia Report

I have been on 100 mg of this drug along with the colcrys for high uric acid. I do not think I have this condition as I think that it is related to the high blood pressure diaritic I am taking. But whatever. I have had diahrea since I started this drug. I hate it. Will talk to Dr. to stop this. It is awful, am tired along with the other side effects noted.

Before taking Allobeta

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking Allobeta it is important that your doctor knows:

  • If you are pregnant or breastfeeding.
  • If you have any problems with the way your liver works, or any problems with the way your k >

Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:

  • skin rash
  • painful urination
  • blood in the urine
  • irritation of the eyes
  • swelling of the lips or mouth
  • fever, sore throat, chills, and other signs of infection
  • loss of appetite
  • unexpected weight loss
  • itching

Allobeta may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What Is Allobeta and How Does It Work?

Allobeta is a prescription medication used to treat gout and certain types of kidney stones. It is also used to prevent increased uric acid levels in patients receiving chemotherapy. These patients can have increased uric acid levels due to the release of uric acid from the dying cancer cells. Allobeta works by reducing the amount of uric acid made by the body. Increased uric acid levels can cause gout and kidney problems.

Allobeta is available under the following different brand names: Zyloprim and Aloprim.

Dosages of Allobeta:

Adult and pediatric dosages:

Powder for injection

Dosage Considerations – Should be Given as Follows:

  • Adult dosage:
  • Mild: 100 mg per day orally initially, increased weekly to 200-300 mg per day
  • Moderate to severe: 100 mg per day orally initially, increased weekly to 400-600 mg per day

Excess of Uric Acid (Hyperuricemia)

  • Pediatric dosage:
  • 10 mg/kg per day orally divided every 12 hours, not to exceed 600 mg/day

Antineoplastic-Induced Excess of Uric Acid (Hyperuricemia)

  • Pediatric dosage:
  • 10 mg/kg per day orally divided every 12 hours, not to exceed 600 mg/day
  • Adult dosage:
  • 600-800 mg divided every 8-12 hours, starting 1-2 days before chemotherapy
  • Intravenously: 200-400 mg/m2 per day, not to exceed 600 mg/m2 per day, may administer as single infusion or in equally divided doses at 6, 8, and 12 hour intervals beginning 1-2 days before chemotherapy
  • Dosing considerations:
  • Minimum oral dosage: 100-200 mg/day
  • Maximum oral dosage: 800 mg/day
  • Dosing modifications:
  • Creatinine clearance 10-20 ml/min: 200 mg/day
  • Creatinine clearance 3-10 ml/min: 100 mg/day
  • Creatinine clearance less than 3 ml/min: 100 mg/day at extended intervals

What is Allobeta and how is it used?

Allobeta (al-oh-pure-ri-nol) is mainly used for the long-term treatment and prevention of gout. Taken regularly, it can stop attacks of gout and help prevent damage to your joints.

It can also be used for treating kidney stones.

The body naturally produces a substance called urate. This normally dissolves in your blood until it’s passed out of the body in your urine. When too much urate is produced, or if your body can’t get rid of it properly, crystals can form in and around your joints. This causes pain and inflammation.

Allobeta blocks an enzyme that is involved in producing urate. This helps the crystals to dissolve and stops attacks of gout.

Allobeta can lower the urate levels in your blood over the space of a few weeks. This will stop new crystals forming.

It can take longer to dissolve crystals that are already there, and you may have more attacks of gout during this time. This is more likely to happen if your urate levels are very high or you’ve had gout for a long time. If this happens to you, it doesn’t mean that your Allobeta isn’t working.

Attacks of gout usually stop within a year, as long as your urate level has gone down enough.

Your doctor will usually be cautious about prescribing Allobeta if you have kidney, thyroid or liver problems.

You will usually be offered Allobeta for gout if blood tests show that your urate level is high and one or more of the following applies:

  • You keep having attacks of gout.
  • Your joints or kidneys have been damaged by attacks of gout.
  • Your skin has been affected by deposits of urate crystals.

Important Information

You should not use Allobeta if you have ever had a serious allergic reaction to it. Stop taking the medicine and call your doctor at once if you have any signs of skin rash, no matter how mild.

Allobeta can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often. Visit your doctor regularly.

Avoid drinking alcohol. It can make your condition worse. Allobeta may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Missed Dose of Allobeta

If you miss a dose of Allobeta, take it as soon as you remember. Skip the missed dose if it is almost time for your next, scheduled dose. Do not take extra medicine to make up for the missed dose.

Rated Allobeta for Gout Report

i am holidaying in cyprus from australia-this is my 3rd attack of gout in about 3 yrs.i did not bring my sachets of "URALS" with me as i assumed i could obtain them here. the urals stops the gout and clear´s it up in about 3 days. i normally take a small sachet once or maybe twice a week but have been a month of "partying" without. the Allobeta (300MG)has started working over the last 4 days and the pain is almost gone and swelling in toe joint nearly gone but still present. it would seem that the urals are a cure/preventitive and the Allobeta is just preventitive.

Dosage for recurrent kidney stones

Adult dosage (ages 18–64 years)

Typical dosage is 200–300 mg per day taken in a single or divided doses.

Child dosage (ages 0–17 years)

This medication hasn’t been studied and shouldn’t be used in people younger than 18 years for this condition.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lowered dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Special considerations

  • For people with kidney disease: Depending on how well your kidneys are working, your doctor will lower your dose. Your doctor will decide your dosage based on your creatinine clearance. This is a test that measures your kidney function.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.

Allobeta oral tablet is used for long-term treatment. It comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all: The uric acid levels in your blood or urine will stay high. If you have gout or kidney stones, you’ll still have symptoms of your condition.

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much: You could have dangerous levels of the drug in your body. Symptoms can include:

  • skin rash
  • diarrhea
  • nausea
  • changes in your liver function test results
  • gout flare-up (if you have gout)

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working: Your doctor will test your uric acid levels to check if this drug is working. Your blood uric acid levels will decrease about 1–3 weeks after you start taking this drug. Your doctor will also ask you about how much fluids you drink and how much fluids you urinate.

Right after you start taking this drug, you may have gout flares. Over time, your symptoms of gout may start to go away.

Keep these considerations in mind if your doctor prescribes Allobeta oral tablet for you.

OVERDOSE

Massive overdosing or acute poisoning by ZYLOPRIM (Allobeta) has not been reported.

In mice, the 50% lethal dose (LD50) is 160 mg/kg given intraperitoneally (IP) with deaths delayed up to 5 days and 700 mg/kg orally (PO) (approximately 140 times the usual human dose) with deaths delayed up to 3 days. In rats, the acute LD50 is 750 mg/kg IP and 6000 mg/kg PO (approximately 1200 times the human dose).

In the management of overdosage there is no specific antidote for ZYLOPRIM (Allobeta) . There has been no clinical experience in the management of a patient who has taken massive amounts of ZYLOPRIM (Allobeta) .

Both ZYLOPRIM (Allobeta) and oxipurinol are dialyzable; however, the usefulness of hemodialysis or peritoneal dialysis in the management of an overdose of ZYLOPRIM (Allobeta) is unknown.

Rated Allobeta for Gout Report

I was prescribed 300 mg for high acid in urine, within 2 weeks I broke out with severe red rash and blisters, after reviewing the lab report, I should have been 100 mg. It has been 1 month since I stopped taking that medication and the blistering has stopped and the rash is slowly starting to go away. I am switching to taking 1/2 tsp of baking soda per day with more water. I have never had a gout attack and feel like I was misdiagnosed.

General

  • Take this drug at the time(s) recommended by your doctor.
  • You can take Allobeta with or without food.
  • Taking this drug after a meal and with lots of water may reduce your chance of upset stomach.
  • You can cut or crush the Allobeta tablet.
  • Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.

Introduction

Allobeta is a xanthine oxidase inhibitor and a widely used medication for gout. Allobeta is a rare but well known cause of acute liver injury that has features of a hypersensitivity reaction and can be severe and even fatal.

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Generic Name: Allobeta (AL oh PURE i nol)Brand Names: Zyloprim, Lopurin, Aloprim

Medically reviewed by Sanjai Sinha, MD Last updated on Dec 17, 2018.


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