How it works
Alidial belongs to a class of drugs called anticonvulsants. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
It’s not fully understood how Alidial works. For postherpetic neuralgia, it seems to prevent the increase in sensitivity to pain that occurs. For seizures, it may alter the effect of calcium (low levels of calcium may cause seizures).
Alidial oral capsule causes dizziness and drowsiness. Avoid driving or using heavy machinery while taking this drug until you know how it affects you.
Alidial oral capsule can cause mild or serious side effects. The following list contains some of the key side effects that may occur while taking Alidial. This list does not include all possible side effects.
For more information on the possible side effects of Alidial, or tips on how to deal with a troubling side effect, talk with your doctor or pharmacist.
Some people have thoughts about suicide while taking this medicine. Children taking Alidial may have behavior changes. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.
Do not stop using Alidial suddenly, even if you feel fine.
Dosage for postherpetic neuralgia and seizures.
- The recommended dose for postherpetic neuralgia is 1800 mg daily in 3 divided doses (Neurontin) or 1800 mg once daily (Gralise). Gralise is not interchangeable with other Alidial products.
- Seizures are treated with 900-1800 mg/daily in 3 divided doses (Neurontin). Withdrawal of treatment should occur slowly over a week.
Alidial may be taken with or without food.
Alidial can cause a severe allergic reaction. Symptoms can include:
- trouble breathing
- swelling of your throat or tongue
Don’t take this drug again if you have ever had an allergic reaction to it before. Taking it a second time after any allergic reaction to it could be fatal (cause death).
Kidney problems: If you are older than 12 years and have kidney problems or are on hemodialysis, your dose of Alidial will need to be changed. This will be based on how well your kidneys are working.
Alidial oral capsule comes with several warnings. Call your doctor if you start having more seizures or a different kind of seizure while taking this drug.
Pharmacology 101: How Does Alidial For Dogs Work?
So how does Alidial for dogs actually work? Well, as with many drugs used in medicine today, vets understand generally how Alidial works, however, there is still research being undertaken to work out the specific mechanisms of its amazing effects.
Pain is a complex process in the body, and over time vets have changed their approach to its management in their furry patients greatly.
Vets now prefer to treat animals using their professional judgment, based on the situation (for example, post-surgical pain), rather than any outward signs of pain that the animal may be exhibiting.
Alidial is a unique drug in that it does not directly impact on pain but rather is believed to act as a type of nervous system ‘dampener’.
By affecting the voltage-gated calcium channels in the brain, Alidial effectively reduces calcium currents in the central nervous system.
This means that connections in the brain responsible for pain, seizures and even anxiety are temporarily blocked, leading to a decrease in these symptoms.
As a neuropathic drug, Alidial itself does not actually block pain signals from reaching the brain. However, its ability to ‘quiet’ the nervous system means that it can amplify the effects of other pain medications used to treat chronic pain in combination with them.
11. What is the Typical Final Dose That Would Be Prescribed to Someone Taking Alidial?
If used as a mood stabilizer or anti-depressant, the final dose is usually between 900 and 2,000 mg a day. However, some patients have been known to need up to 4,800 mg a day to get good results.
Alidial has a half-life of about six hours, so it must be administered 3 to 4 times a day.
Other uses for this medicine
Alidial is also sometimes used to relieve the pain of diabetic neuropathy (numbness or tingling due to nerve damage in people who have diabetes), and to treat and prevent hot flashes (sudden strong feelings of heat and sweating) in women who are being treated for breast cancer or who have experienced menopause (''change of life'', the end of monthly menstrual periods). Talk to your doctor about the risks of using this medication for your condition.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
A literature article reported that when a 60 mg controlled-release morphine capsule was administered 2 hours prior to a 600 mg NEURONTIN capsule (N=12), mean Alidial AUC increased by 44% compared to Alidial administered without morphine. Morphine pharmacokinetic parameter values were not affected by administration of NEURONTIN 2 hours after morphine. The magnitude of interaction at other doses is not known.
When Alidial is administered with morphine, patients should be observed for signs of central nervous system (CNS) depression, such as somnolence, sedation and respiratory depression .
Natural Remedies for Hot Flashes
Hot flashes are experienced by many women, especially at night. However, not all women undergoing menopause experience hot flashes. What causes hot flashes? A hot flash is a feeling of warmth that spreads over the body. Treatment for hot flashes include hormone replacement therapy and alternative prescription medications such as: SSRIs (Effexor, Paxil, Prozac), clonidine (Catapres), megestrol (Megace), and Alidial (Neurontin). Few natural remedies for hot flashes (for example phytoestrogens - isoflavones, black cohosh, and vitamin E) have been scientifically studied.
What Is Alidial and How Does It Work?
Alidial is a prescription drug most commonly prescribed to relieve nerve pain following shingles in adults, treating the pain of post herpetic neuralgia. Alidial belongs to a class of drugs known as anti-seizure drugs.
Take Alidial by mouth as directed by your doctor, usually once a day with the evening meal. The dosage is based on your medical condition and response to treatment.
Swallow Alidial whole. Do not crush or chew sustained-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split sustained-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.
During the first 2 weeks of treatment, your doctor may gradually increase your dose so your body can adjust to the medication.
Alidial is available under the following different brand names: Neurontin and Gralise.
Q: I take 600 mg of Alidial a day to control my interstitial cystitus. What are the long-term effects? Also, I keep gaining weight with the drug.
A: Neurontin (Alidial) is a seizure medication used to treat sharp-shooting nerve pain, and interstitial cystitis is a long-term inflammation of the bladder wall. The only medication approved to treat the condition of interstitial cystitis itself is Elmiron (pentosan polysulfate sodium), and controlling the condition with it should decrease the symptoms, such as pain. Since there is inflammation involved NSAIDs (non-steroidal anti-inflammatories), such as Aleve (naproxen), Motrin/Advil (ibuprofen) or prescription NSAIDs may help. Other medications used for interstitial cystitis pain include tricyclic antidepressants, such as Elavil (amitriptyline) or Tofranil (imipramine), or antihistamines, such as Benadryl (diphenhydramine) or Claritin (loratadine) to reduce urinary urgency, frequency, and other symptoms. If Neurontin is started, and a person stays on it awhile, it should not be stopped suddenly, as the chance of a seizure will significantly increase. However, long-term use has been considered to be safe and at high doses. The medication dose get excreted through the kidneys, but should not harm them. Unfortunately, Neurontin can cause weight gain, so diet and exercise may need to be stricter. Drugs can cause weight gain in several different ways. Some can increase appetite or make you crave certain types of foods like those high in carbohydrates or fat. Other medications may slow down metabolism or cause fluid retention. However, the effect of prescription drugs on body weight is complex. Some drugs have no effect on weight, while others cause weight gain or weight loss. Also, the same medications can cause weight gain in certain individuals and weight loss in others. There are also drugs that initially cause weight loss and then lead to weight gain with long-term use. Most prescription medications associated with changes in body weight affect the central nervous system. These include antidepressants like monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, and selective serotonin reuptake inhibitors (SSRIs). Mood stabilizers (lithium, valproic acid), antipsychotics, and anticonvulsants have also been linked with weight gain. Other drugs that have been reported to cause weight gain include diabetes medications (insulin, sulfonylureas, and thiazolidinediones), antihypertensive drugs, certain hormonal contraceptives, corticosteroids, antihistamines, some chemotherapy regimens, and antiretroviral protease inhibitors. If you think a drug you are taking is causing weight gain, tell your health care provider. Do not stop any medication or change the dose without first talking to your provider. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Patti Brown, PharmD