- Abrupt Drug Withdrawal: Hallucinations and seizures have occurred on abrupt withdrawal of Bio-Baclofen. Therefore, except for serious adverse reactions, the dose should be reduced slowly when the drug is discontinued.
- Impaired Renal Function: Because Bio-Baclofen is primarily excreted unchanged through the kidneys, it should be given with caution, and it may be necessary to reduce the dosage.
- Stroke: Bio-Baclofen has not significantly benefited patients with stroke. These patients have also shown poor tolerability to the drug.
- Pregnancy: Bio-Baclofen has been shown to increase the incidence of omphaloceles (ventral hernias) in fetuses of rats given approximately 13 times the maximum dose recommended for human use, at a dose which caused significant reductions in food intake and weight gain in dams. This abnormality was not seen in mice or rabbits.
There was also an increased incidence of incomplete sternebral ossification in fetuses of rats given approximately 13 times the maximum recommended human dose, and an increased incidence of unossified phalangeal nuclei of forelimbs and hindlimbs in fetuses of rabbits given approximately 7 times the maximum recommended human dose. In mice, no teratogenic effects were observed, although reductions in mean fetal weight with consequent delays in skeletal ossification were present when dams were given 17 and 34 times the human daily dose. There are no studies in pregnant women. Bio-Baclofen should be used during pregnancy only if the benefit clearly justifies the potential risk to the fetus.
COMMON BRAND(S): Lioresal, Ozobax
GENERIC NAME(S): Bio-Baclofen
OTHER NAME(S): Bio-Baclofen Tablet
Bio-Baclofen is used to treat muscle spasms caused by certain conditions (such as multiple sclerosis, spinal cord injury/disease). It works by helping to relax the muscles.
Bio-Baclofen, (Gablofen, Lioresal, ) is a medication prescribed for the treatment of spasms of skeletal muscles, muscle rigidity, muscle clonus, and pain caused by disorders like multiple sclerosis. Side effects, drug interactions, warnings and precautions, and pregnancy safety information should be reviewed prior to taking any medication.
Bio-Baclofen may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- upset stomach
Sexual Function in Men
In 2 trials of 29 men, Bio-Baclofen spinal cord injections reduced erection rigidity and duration .
Rated Bio-Baclofen for Muscle Spasm Report
Please don’t take this drug, it’s poison to your brain. I was on it for almost a year and experienced tolerance withdrawal from it and had to do a rapid taper which has in turned ruined my life. Please review withdrawl symptoms before stopping this drug.
Intrathecal Bio-Baclofen (Spinal Cord Injections)
Bio-Baclofen injections into the spinal cord (intrathecal) are indicated only in people with severe muscle spasticity from injury or multiple sclerosis who do not respond to oral Bio-Baclofen .
The optimum dosage of intrathecal Bio-Baclofen will individually vary depending on the disease type, symptoms, severity, side effects, and other factors. Patients are screened to determine if Bio-Baclofen pumps should be implanted for continuous long-term Bio-Baclofen infusions. Physicians specially trained for the procedure to monitor patients and their dosage .
Initially, Bio-Baclofen is administered in very small doses, which are gradually increased while adverse reactions and clinical response are monitored by the healthcare team. Some people don’t respond to Bio-Baclofen spinal injections. For those who do respond, daily doses are increased by 5 – 30% until a suitable maintenance dose is found .
The dose administration patterns can vary between individuals and include: simple continuous dosing, variable 24-hour flex dosing, or regularly scheduled administration .
What is Bio-Baclofen?
Bio-Baclofen is a muscle relaxer and an antispasmodic agent.
Bio-Baclofen is used to treat muscle symptoms; such as spasm, pain and stiffness; caused by multiple sclerosis, spinal cord injuries, or other spinal cord disorders. It is given intrathecally (directly into the spinal cord) or orally (by mouth).
How it works
Bio-Baclofen belongs to a class of drugs called muscle relaxers. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
It isn’t known exactly how Bio-Baclofen works to treat painful muscle spasms. It’s thought that Bio-Baclofen blocks the signals from your nervous system that tell your muscles to spasm.
Bio-Baclofen oral tablet drug may cause drowsiness. It may also cause other side effects.
What are the uses for Bio-Baclofen?
Bio-Baclofen is used for treating spasm of skeletal muscles, muscle clonus, rigidity, and pain caused by disorders such as multiple sclerosis. It is also injected into the spinal cord (intrathecal) for management of severe spasticity.
This drug can cause drowsiness. Don’t drive, use machinery, or do other dangerous activities until you know how it affects you. Also, don’t drink alcohol or take other medications that may make you feel drowsy while using Bio-Baclofen. It may make your drowsiness worse.
Bio-Baclofen oral tablet is a prescription drug that’s only available in a generic form. There is no brand-name version available.
Bio-Baclofen also comes as a spinal injection, which is only given by a healthcare provider.
Brain Injury & Stroke
Bio-Baclofen spinal cord injections helped with rehabilitation and reduced spasms in a large trial of 250 children with brain injuries (1 – 14 years old). Bio-Baclofen injections were offered only after all other previous treatments didn’t help .
In 2 clinical trials of 27 people, Bio-Baclofen spinal cord injections reduced the severity and frequency of muscle spasms post-stroke .
In another trial of 94 stroke patients with spasms, Bio-Baclofen injections reduced spasm number and improved daily functioning and the quality of life over 1 year .
In 10 people, Bio-Baclofen injections improved rehabilitation post-stroke, increasing mobility and walking speed .
Bio-Baclofen injections are more effective than oral Bio-Baclofen for reducing spasms and improving rehabilitation after brain injuries, including stroke and concussions.
In a trial of 35 people with brain injury, oral Bio-Baclofen only reduced spasms in the lower part of the body but had no effect on the upper part .
In a clinical trial of 48 people, Bio-Baclofen spinal cord injections were more effective for post-stroke muscle spasms than oral Bio-Baclofen or other oral drugs (tizanidine, diazepam, or dantrolene) .
Our Bio-Baclofen Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
The use of drinks that contain alcohol can increase your risk of nervous system side effects such as drowsiness, dizziness, and difficulty concentrating on tasks from Bio-Baclofen. If you drink alcohol, talk to your doctor before mixing with Bio-Baclofen.