Baclofeno tablets

Baclofeno

  • Active Ingredient: Baclofen
  • 25 mg, 10 mg
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What is Baclofeno?

The active ingredient of Baclofeno brand is baclofen. Baclofen is a muscle relaxer and an antispastic agent. Baclofen Tablets, USP 10 mg and 20 mg contain the following inactive ingredients: colloidal silicon dioxide, crospovidone, magnesium stearate, microcrystalline cellulose and pregelatinized starch.

Used for

Baclofeno is used to treat diseases such as: Alcohol Withdrawal, Cerebral Spasticity, Cervical Dystonia, Chronic Spasticity, Cluster-Tic Syndrome, Dystonia, Hiccups, Huntington's Disease, Migraine Prevention, Muscle Spasm, Muscle Twitching, Neuralgia, Periodic Limb Movement Disorder, Spasticity, Spinal Spasticity, Temporomandibular Joint Disorder, Trigeminal Neuralgia.

Side Effect

Possible side effects of Baclofeno include: intrathecal kit, intrathecal solution; Confusion; ringing or buzzing in the ears; increase in muscle spasm, cramping, or tightness; muscle or joint pain; Abdominal or stomach pain or discomfort; drowsiness.

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What are the uses for Baclofeno?

Baclofeno is used for treating spasm of skeletal muscles, muscle clonus, rigidity, and pain caused by disorders such as multiple sclerosis. It is also injected into the spinal cord (intrathecal) for management of severe spasticity.

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Baclofeno Interactions

Baclofeno can interact with the following drugs :

  • Other muscle relaxants
  • Parkinson’s Disease drugs
  • Anti-seizure drugs
  • Antidepressants and lithium
  • Drugs for high blood pressure
  • Other drugs that affect kidney function, such as ibuprofen
  • Opioid drugs for pain relief
  • Drugs for insomnia or anxiety
  • Antihistamines and sedatives

It’s not recommended to consume alcohol while on Baclofeno, since this can cause additional sleepiness, dizziness, and may even lead to coma.

Tell your doctor, nurse, or pharmacist about the medication you are taking or were recently taking, including herbal and over-the-counter drugs.

Baclofeno Withdrawal

Baclofeno can cause withdrawal symptoms if suddenly discontinued after long-term use.

Withdrawal symptoms include :

  • High fever
  • Altered mental status
  • Low blood pressure
  • Worsening of muscle spasticity
  • Muscle rigidity
  • In rare cases: serious muscle damage (rhabdomyolysis), multiple organ failure, and death.

Withdrawal symptoms start to appear within a couple of hours to days after stopping the drug. These were reported mostly after discontinuing pumps that deliver Baclofeno spinal injections.

In a 13-year study on 27 people, 5 Baclofeno users experienced hallucinations after they suddenly stopped taking the drug .

In pregnant women, Baclofeno can cause withdrawal symptoms in newborn babies that include irritability, high-pitched crying, trembling, increased muscle tone, excessive sucking, disordered sleep, increase in body temperature, uneven discolored patches on the skin, and convulsions sometime after delivery .

Sexual Function in Men

In 2 trials of 29 men, Baclofeno spinal cord injections reduced erection rigidity and duration .

5) Opioid Addiction and Withdrawal

Baclofeno is emerging as new drug therapy for people with opioid addiction or going through opioid withdrawal. The studies are still limited.

In 2 recent trials lasting 2 – 12 weeks on 102 people with opioid addiction, oral Baclofeno reduced the physical symptoms of opioid withdrawal, and improved mood and mental symptoms. It also slightly reduced craving. Baclofeno works by increasing GABA in the brain, which can help with both the addiction and with withdrawal .

What Drugs, Substances, or Supplements Interact with Baclofeno

Combining Baclofeno and tricyclic antidepressants may cause muscle weakness. Use of Baclofeno and monoamine oxidase inhibitors (MAOIs) can result in greater depression of brain function as well as low blood pressure.

Hepatotoxicity

Limited data are available on the potential hepatotoxicity of Baclofeno. Among the many clinical trials evaluating the safety and efficacy of Baclofeno, none mentioned hepatic toxicity or rates of serum ALT elevations occurring during chronic therapy. The product insert starts that 5% of treated patients develop mild serum aminotransferase elevations, but little documentation is available on the significance, severity or duration of these abnormalities. A single case of mild and self-limited hepatitis attirbuted to Baclofeno has been published. The latency to onset was 3 months, the pattern of injury was hepatocellular, and recovery was rapid and complete, all laboratory tests being normal within a few weeks of stopping.

Likelihood score: D (Possible, rare cause of clinically apparent liver injury).

Background

Baclofeno (bak' loe fen) is a gamma-amino butyric acid (GABA) derivative that acts as an agonist of the GABA B receptor, thereby activating potassium channels and reducing calcium conductance leading to hypotonia and muscle relaxation. Baclofeno acts primarily at the level of the spinal cord, inhibiting synaptic reflexes. Baclofeno reduces the number and severity of muscle spasms and relieves pain, clonus and muscle rigidity due to spasticity. Baclofeno is indicated primarily for treatment of spasticity from spinal cord injuries and multiple sclerosis. It has been used off label as adjunctive therapy to help with alcohol abstinence and withdrawal. Baclofeno was approved for use in the United States in 1977 and is widely used with several million prescriptions filled yearly. Baclofeno is available in various generic forms as well as under the brand names of Lioresal and Remular in tablets of 10 or 20 mg and in formulations for intrathecal injections of 0.5 mg/mL. The recommended adult dose for spasticity is 10 to 20 mg orally three to four times daily. The dose should be increased and tapered gradually. The most common side effects of Baclofeno are nausea, drowsiness, confusion, dizziness and fatigue.

Additional Information

Our Baclofeno Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Rated Baclofeno for Muscle Spasm Report

Please don’t take this drug, it’s poison to your brain. I was on it for almost a year and experienced tolerance withdrawal from it and had to do a rapid taper which has in turned ruined my life. Please review withdrawl symptoms before stopping this drug.


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