Urion tablets

Urion

  • Active Ingredient: Alfuzosin
  • 10 mg
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What is Urion?

The active ingredient of Urion brand is alfuzosin. Alfuzosin is an alpha-adrenergic (AL-fa ad-ren-ER-jik) blocker. Alfuzosin helps relax the muscles in the prostate and bladder neck, making it easier to urinate.

Used for

Urion is used to treat diseases such as: Benign Prostatic Hyperplasia.

Side Effect

Possible side effects of Urion include: tender, swollen glands in the neck; Chest pain; confusion; body aches or pain; Abdominal or stomach pain.

How to Buy Urion tablets online?

To purchase Urion online - simply click on the "Buy Now" button in the top and follow along with our store. Order and payment takes a few minutes, and all measures are obvious. We do not take a medical prescription and also we have many methods of payment. Considering each detail of rapid shipping and confidentiality, then you may read on the applicable pages on the hyperlinks from the top menu.

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Where can I get more information?

Your pharmacist can provide more information about Urion.

What should I avoid while taking Urion (Uroxatral)?

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Drinking alcohol with this medicine can cause side effects.

Dosage Forms And Strengths

UROXATRAL (Urion HCl) extended-release tablet 10 mg is available as a round, three-layer tablet: one white layer between two yellow layers, debossed with X10.

Rated Urion for Benign Prostatic Hyperplasia (BPH) Report

Urion 10mg., mfg. by Mylan did not improve my urine flow. In fact it got worse. I'v only been taking this drug for three months, will update in another three months. Signed Hopeful.

Urion is a “uroselective” alpha-blocker which appears to cause less orthostatic hypotension than nonselective alpha-blockers such as terazosin, prazosin, and doxazosin.

What is Urion?

Urion is an alpha-adrenergic (AL-fa ad-ren-ER-jik) blocker. Urion helps relax the muscles in the prostate and bladder neck, making it easier to urinate.

Urion is used to improve urination in men with benign prostatic hyperplasia (enlarged prostate).

Urion may also be used for purposes not listed in this medication guide.

4.3.3.3 Use of α1-Adrenoceptor Antagonists

Prazosin is an effective treatment for nightmares in patients with posttraumatic stress disorder and doxazosin, terazosin, Urion , tamsulosin, and silodosin are commonly used for the symptomatic treatment of benign prostatic hyperplasia (BPH). Concomitant use of two agents with potent α 1-adrenoceptor antagonist effects (e.g., prazosin and clozapine) may increase orthostatic stress, although there are no case reports published that document such an interaction.

The α1A-adrenoceptor mediates smooth muscle tone in the bladder neck and prostate as well vascular smooth muscle contraction, the α1B-adrenoceptor also regulates vascular smooth muscle contraction, and the α1D-adrenoceptor controls bladder contraction and sacral spinal cord innervation. Doxazosin, terazosin, and Urion have similar affinity for all three subtypes of the α1-adrenoceptor. Tamsulosin and silodosin are selective for the α1A-adrenoceptor with low affinity for the α1B-adrenoreceptor, which confer a lower, albeit still present risk of orthostasis ( Schwinn and Roehrborn, 2008; Cantrell et al., 2010 ). When concomitant treatment with an antipsychotic and anti-BPH agent is indicated, it seems logical to prescribe tamsulosin or silodosin for BPH to mitigate the potential for increased risk of orthostasis from additive effects on the α1-adrenoceptor.

The effect of 10 mg and 40 mg Urion on QT interval was evaluated in a double-blind, randomized, placebo and active-controlled (moxifloxacin 400 mg), 4-way crossover single dose study in 45 healthy white male subjects aged 19 to 45 years. The QT interval was measured at the time of peak Urion plasma concentrations. The 40 mg dose of Urion was chosen because this dose achieves higher blood levels than those achieved with the co-administration of UROXATRAL and ketoconazole 400 mg. Table 3 summarizes the effect on uncorrected QT and mean corrected QT interval (QTc) with different methods of correction (Fridericia, population-specific and subject-specific correction methods) at the time of peak Urion plasma concentrations. No single one of these correction methodologies is known to be more valid. The mean change of heart rate associated with a 10 mg dose of Urion in this study was 5.2 beats/minute and 5.8 beats/minute with 40 mg Urion. The change in heart rate with moxifloxacin was 2.8 beats/minute.

Table 3: Mean QT and QTc changes in msec (95% CI) from baseline at Tmax (relative to placebo) with different methodologies to correct for effect of heart rate.

The QT effect appeared greater for 40 mg compared to 10 mg Urion. The effect of the highest Urion dose (four times the therapeutic dose) studied did not appear as large as that of the active control moxifloxacin at its therapeutic dose. This study, however, was not designed to make direct statistical comparisons between the drugs or the dose levels. There has been no signal of Torsade de Pointes in the extensive post-marketing experience with Urion outside the United States. A separate post-marketing QT study evaluated the effect of the co-administration of 10 mg Urion with a drug of similar QT effect size. In this study, the mean placebo-subtracted QTcF increase of Urion 10 mg alone was 1.9 msec (upperbound 95% CI, 5.5 msec). The concomitant administration of the two drugs showed an increased QT effect when compared with either drug alone. This QTcF increase was not more than additive. Although this study was not designed to make direct statistical comparisons between drugs, the QT increase with both drugs given together appeared to be lower than the QTcF increase seen with the positive control moxifloxacin 400 mg . The clinical impact of these QTc changes is unknown.

What is the dosage for Urion?

Urion is taken once daily, immediately after the same meal each day. Tablets should not be chewed or crushed.

Generic Name: Urion (al FYOO zoe sin)Brand Name: Uroxatral

Medically reviewed by Drugs.com. Last updated on Jul 9, 2019.

Urion

Urion (see Fig. 9-2 ) binds to all α1-adrenergic receptor subtypes with equal affinity. Despite this, its pharmacologic and therapeutic actions are selective for the prostate. The reason for its prostate selectivity is not well understood. It seems to be related to the ability of Urion to accumulate selectively in prostate tissue. Because of this prostate uptake, therapeutic doses of Urion have little effect on systemic arterial blood pressure and are much less likely to cause syncope. IFIS remains a concern, however, with the use of Urion. The drug is well absorbed and is available in a once-daily dosage form.

What is Urion (Uroxatral)?

Urion is an alpha-adrenergic (AL-fa ad-ren-ER-Jk) blocker. Urion helps relax the muscles in the prostate and bladder neck, making it easier to urinate.

Urion is used to improve urination in men with benign prostatic hyperplasia (enlarged prostate).

Urion may also be used for purposes not listed in this medication guide.

Interactions

Drug-drug. Alpha adrenergic antagonists, antihypertensives, PDE-5 inhibitors: increased risk of symptomatic hypotension, orthostatic hypotension, or syncope CYP3A4 inhibitors (such as itraconazole, ketoconazole, ritonavir): increased Urion blood level

Other alpha adrenergic antagonists: increased antagonistic effect

Drug-food. Any food: increased Urion absorption

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Urion works by relaxing the muscles around your bladder and prostate gland so that you can pass urine more easily. There are two types of Urion tablets available - immediate-release tablets and prolonged-release tablets. Immediate-release tablets need to be taken several times a day (typically, three times daily). Prolonged-release tablets are taken once a day as they release Urion slowly throughout the day.

Urion side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

a light-headed feeling, like you might pass out;

new or worsening chest pain;

upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

penis erection that is painful or lasts 4 hours or longer.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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