Prostazosina belongs to a group of medicines known as alpha-blockers. It works by blocking the action of certain nerve impulses. This blocking action is useful in two different medical conditions. It is used to help control the symptoms of prostate gland enlargement, and it also reduces blood pressure in people with hypertension.
What is the dosage for Prostazosina mesylate?
The recommended dose of Prostazosina for hypertension is 1-16 mg daily. The recommended dose for benign prostatic hyperplasia is 1-8 mg daily.
Rated Prostazosina for Benign Prostatic Hyperplasia (BPH) Report
I take 4 mg I get up no more then once a night instead of 2 or 3 times.
Prostazosina and Pregnancy
It's not known whether Prostazosina will harm an unborn baby. You should tell your doctor if you are pregnant or might become pregnant while taking this medication.
It's also not known whether the drug passes into breast milk or if it could harm a breastfeeding baby.
Prostazosina can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using Prostazosina. Do not stop using this medicine before surgery unless your surgeon tells you.
You should not use this medication if you are allergic to Prostazosina or similar medicines such as alfuzosin (Uroxatral), prazosin (Minipress), silodosin (Rapaflo), tamsulosin (Flomax), or terazosin (Hytrin). Prostazosina may cause dizziness or fainting, especially when you first start taking it or when you start taking it again. Be careful if you drive or do anything that requires you to be alert. Avoid standing for long periods of time or becoming overheated during exercise and in hot weather. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
Tell your doctor about all other medications you use, especially other blood pressure medications including diuretics (water pills).
1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
2. "Product Information. Cardura (Prostazosina)." Pfizer US Pharmaceuticals, New York, NY.
Alpha1 antagonists, including Prostazosina, have been associated with priapism (painful penile erection, sustained for hours and unrelieved by sexual intercourse or masturbation). This condition can lead to permanent impotence if not promptly treated.
CARDURA has been administered to approximately 4000 hypertensive patients in clinical trials, of whom 1679 were included in the hypertension clinical development program. In placebo-controlled studies, adverse events occurred in 49% and 40% of patients in the Prostazosina and placebo groups, respectively, and led to discontinuation in 2% of patients in each group.
Adverse reactions occurring more than 1% more frequently in hypertensive patients treated with CARDURA vs placebo are summarized in Table 1. . Postural effects and edema appeared to be dose-related. The prevalence rates presented below are based on combined data from placebo-controlled studies involving once-daily administration of Prostazosina at doses ranging from 1 to 16 mg.
Table 2: Adverse Reactions Occurring more than 1% More Frequently in Hypertensive Patients Treated with Cardura versus Placebo
Other adverse reactions occurring less than 1% more frequently in hypertensive patients treated with CARDURA vs placebo but plausibly related to CARDURA use include vertigo, hypotension, hot flushes, epistaxis and oedema.
CARDURA has been associated with decreases in white blood cell counts
Taking certain antidepressants with Prostazosina can increase your risk of low blood pressure when standing up from sitting or lying down. Examples of these drugs include:
Is Prostazosina mesylate safe to take if I'm pregnant or breastfeeding?
There are no adequate studies of Prostazosina in pregnant women.
There are no adequate studies of Prostazosina in nursing mothers.
In a pooled analysis of placebo-controlled hypertension studies with about 300 hypertensive patients per treatment group, Prostazosina, at doses of 1 to 16 mg given once daily, lowered blood pressure at 24 hours by about 10/8 mmHg compared to placebo in the standing position and about 9/5 mmHg in the supine position. Peak blood pressure effects (1–6 hours) were larger by about 50–75% (i.e., trough values were about 55–70% of peak effect), with the larger peak-trough differences seen in systolic pressures. There was no apparent difference in the blood pressure response of Caucasians and blacks or of patients above and below age 65. In the same patient population, patients receiving CARDURA gained a mean of 0.6 kg compared to a mean loss of 0.1 kg for placebo patients.
TABLE 4 : Mean Changes in Blood Pressure from Baseline to the Mean of the Final Efficacy Phase in Normotensives (Diastolic BP
Taking amifostine with Prostazosina increases your risk of low blood pressure.