Naflox tablets

Naflox

  • Active Ingredient: Norfloxacin
  • 400 mg
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What is Naflox?

The active ingredient of Naflox brand is norfloxacin. The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content.

Used for

Naflox is used to treat diseases such as: Bladder Infection, Campylobacter Gastroenteritis, Epididymitis, Non-Specific, Gonococcal Infection, Uncomplicated, Kidney Infections, Prostatitis, Salmonella Enteric Fever, Salmonella Gastroenteritis, Shigellosis, Traveler's Diarrhea, Urinary Tract Infection.

Side Effect

Possible side effects of Naflox include: large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs; bleeding gums; bone pain; numbness or tingling in the hands, feet, or lips; discouragement.

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Brand Names: Canada

ALTI-Naflox; APO-Naflox; CO Naflox ; PMS-Naflox ; TEVA-Naflox

DOSAGE AND ADMINISTRATION

Tablets NOROXIN should be taken at least one hour before or at least two hours after a meal or ingestion of milk and/or other dairy products. Multivitamins, other products containing iron or zinc, antacids containing magnesium and aluminum, sucralfate, or Videx® (Didanosine), chewable/buffered tablets or the pediatric powder for oral solution, should not be taken within 2 hours of administration of Naflox. Tablets NOROXIN should be taken with a glass of water. Patients receiving NOROXIN should be well hydrated (see PRECAUTIONS).

DRUG INTERACTIONS

Quinolones, including NOROXIN, have been shown in vitro to inhibit CYP1A2. Concomitant use with drugs metabolized by CYP1A2 (e.g., caffeine, clozapine, ropinirole, tacrine, theophylline, tizanidine) may result in increased substrate drug concentrations when given in usual doses. Patients taking any of these drugs concomitantly with Naflox should be carefully monitored.

Elevated plasma levels of theophylline have been reported with concomitant quinolone use. There have been reports of theophylline-related side effects in patients on concomitant therapy with Naflox and theophylline. Therefore, monitoring of theophylline plasma levels should be considered and dosage of theophylline adjusted as required.

Elevated serum levels of cyclosporine have been reported with concomitant use of cyclosporine with NOROXIN. Therefore, cyclosporine serum levels should be monitored and appropriate cyclosporine dosage adjustments made when these drugs are used concomitantly.

Quinolones, including NOROXIN, may enhance the effects of oral anticoagulants, including warfarin or its derivatives or similar agents. When these products are administered concomitantly, prothrombin time or other suitable coagulation tests should be closely monitored.

The concomitant administration of quinolones including NOROXIN with glyburide (a sulfonylurea agent) has, on rare occasions, resulted in severe hypoglycemia. Therefore, monitoring of blood glucose is recommended when these agents are co-administered.

Diminished urinary excretion of NOROXIN has been reported during the concomitant administration of probenecid and NOROXIN.

The concomitant use of nitrofurantoin is not recommended since nitrofurantoin may antagonize the antibacterial effect of NOROXIN in the urinary tract.

Multivitamins, or other products containing iron or zinc, antacids or sucralfate, should not be administered concomitantly with, or within 2 hours of, the administration of NOROXIN, because they may interfere with absorption resulting in lower serum and urine levels of NOROXIN.

Videx® (Didanosine) chewable/buffered tablets or the pediatric powder for oral solution should not be administered concomitantly with, or within 2 hours of, the administration of NOROXIN, because these products may interfere with absorption resulting in lower serum and urine levels of NOROXIN.

Some quinolones have also been shown to interfere with the metabolism of caffeine. This may lead to reduced clearance of caffeine and a prolongation of the plasma half-life that may lead to accumulation of caffeine in plasma when products containing caffeine are consumed while taking NOROXIN.

The concomitant administration of a non-steroidal anti-inflammatory drug (NSAID) with a quinolone, including NOROXIN, may increase the risk of CNS stimulation and convulsive seizures. Therefore, NOROXIN should be used with caution in individuals receiving NSAIDS concomitantly.

What do I need to tell my doctor BEFORE I take Naflox?

For all patients taking Naflox:

  • If you have an allergy to Naflox or any other part of Naflox.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Long QT on ECG, low magnesium levels, or low potassium levels.
  • If you have ever had any of these health problems: Nerve problems or tendon problems.
  • If you have had tendons get irritated or torn when taking Naflox or an alike drug in the past.
  • If you are not able to pass urine.
  • If you are taking probenecid.
  • If you have been taking any drugs to treat a heartbeat that is not normal.
  • If you are taking any drugs that can cause a certain type of heartbeat that is not normal (prolonged QT interval). There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.

  • If the patient is a child. This medicine is not approved for use in children.

This is not a list of all drugs or health problems that interact with Naflox.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Naflox with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

Elimination

The terminal half-lives of elimination from serum range from 3 hours for Naflox and ciprofloxacin to 12 hours for moxifloxacin, allowing twice- or once-daily dosing (see Table 34-4 ; Table 34-6 ). The principal routes of elimination differ among quinolones. Ofloxacin, levofloxacin, and sitafloxacin are eliminated predominantly by the kidneys, and nalidixic acid and moxifloxacin are eliminated predominantly by nonrenal pathways. Most other quinolones have mixed excretion by both renal and nonrenal routes.

TABLE 34-6 . Dosing of Quinolones in Patients with Normal and Reduced Renal Function

Syphilis Treatment

Naflox has not been shown to be effective in the treatment of syphilis. Antimicrobial agents used in high doses for short periods of time to treat gonorrhea may mask or delay the symptoms of incubating syphilis. All patients with gonorrhea should have a serologic test for syphilis at the time of diagnosis. Patients treated with Naflox should have a follow-up serologic test for syphilis after three months.

Generic Name: Naflox (nor FLOKS a sin)

Medically reviewed by Drugs.com. Last updated on Jun 14, 2019.


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