Key facts about Lexinor
- Lexinor is not suitable for children, or pregnant or breastfeeding women.
- Nofloxacin is usually taken twice a day. Take the tablets on an empty stomach and complete the prescribed course.
- Don't drink milk or take indigestion remedies or medicines containing calcium, iron or zinc in the two hours before or after taking a Lexinor dose.
- Don't take anti-inflammatories like ibuprofen while you're taking Lexinor.
- Protect your skin from sunlight and don't use sunbeds or sunlamps while you're taking Lexinor.
- The most common s >Lexinor is not suitable for:
- Children and growing adolescents.
- Women who are pregnant or breastfeeding.
- People who are allergic to other quinolone-type antibiotics, eg ofloxacin, ciprofloxacin, nal >
Lexinor is active against many gram-positive bacteria and gram-negative bacteria. Relatively long post-antibiotic effect. Lexinor is less potent than ciprofloxacin and is not used to treat systemic infections.
How to take Lexinor
- Before you start taking the tablets, read the manufacturer's printed information leaflet from ins >
How does Lexinor work?
Lexinor is a type of medicine called a quinolone antibiotic. It works by interfering with a bacterial enzyme involved in replicating and repairing the genetic material (DNA) of bacteria. If this enzyme doesn't work, the bacteria cannot reproduce or repair themselves. This kills the bacteria and clears up the infection.
Your doctor may ask you for a urine sample to make sure the bacteria causing your infection are susceptible to Lexinor.
Before taking Lexinor
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking Lexinor it is important that your doctor knows:
- If you are pregnant, trying for a baby, or breast-feeding.
- If you are under 18 years of age.
- If you have ever experienced a problem with your tendons after taking another quinolone antibiotic (these are called ofloxacin, levofloxacin, ciprofloxacin, moxifloxacin, and nal >
Can Lexinor cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with Lexinor. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Needle-shaped crystals were found in the urine of some volunteers who received either placebo, 800 mg Lexinor, or 1600 mg Lexinor (at or twice the recommended daily dose, respectively) while participating in a double-blind, crossover study comparing single doses of Lexinor with placebo. While crystalluria is not expected to occur under usual conditions with a dosage regimen of 400 mg b.i.d., as a precaution, the daily recommended dosage should not be exceeded and the patient should drink sufficient fluids to ensure a proper state of hydration and adequate urinary output.
Alteration in dosage regimen is necessary for patients with impaired renal function (see DOSAGE AND ADMINISTRATION).
Moderate to severe photosensitivity/phototoxicity reactions, the latter of which may manifest as exaggerated sunburn reactions (e.g., burning, erythema, exudation, vesicles, blistering, edema) involving areas exposed to light (typically the face, “V” area of the neck, extensor surfaces of the forearms, dorsa of the hands), can be associated with the use of quinolone antibiotics after sun or UV light exposure.
Therefore, excessive exposure to these sources of light should be avoided. Drug therapy should be discontinued if phototoxicity occurs (see ADVERSE REACTIONS, Post-Marketing).
Rarely, hemolytic reactions have been reported in patients with latent or actual defects in glucose-6phosphate dehydrogenase activity who take quinolone antibacterial agents, including Lexinor (see ADVERSE REACTIONS).
Prescribing NOROXIN in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.