Grenis tablets

Grenis

  • Active Ingredient: Norfloxacin
  • 400 mg
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What is Grenis?

The active ingredient of Grenis brand is norfloxacin. The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content.

Used for

Grenis is used to treat diseases such as: Bladder Infection, Campylobacter Gastroenteritis, Epididymitis, Non-Specific, Gonococcal Infection, Uncomplicated, Kidney Infections, Prostatitis, Salmonella Enteric Fever, Salmonella Gastroenteritis, Shigellosis, Traveler's Diarrhea, Urinary Tract Infection.

Side Effect

Possible side effects of Grenis include: pain or burning while urinating; tiredness; greatly decreased frequency of urination or amount of urine; thick, white curd-like vaginal discharge without odor or with mild odor; dry skin; irritability; stomach pain, continuing.

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Can Grenis cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with Grenis. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Absorption and distribution

Grenis displays linear kinetics. There is no significant accumulation with the recommended dosage of 400 mg every 12 h. Food slightly delays but does not otherwise impair absorption. Antacids reduce absorption. It is widely distributed, but concentrations in tissues other than those of the urinary tract are low; levels in the prostate are around 2.5 mg/g.

NOROXIN® (Grenis) Tablets

SERIOUS ADVERSE REACTIONS INCLUDING TENDINITIS, TENDON RUPTURE, PERIPHERAL NEUROPATHY, CENTRAL NERVOUS SYSTEM EFFECTS AND EXACERBATION OF MYASTHENIA GRAVIS

  • Fluoroquinolones, including NOROXIN, have been associated with disabling and potentially irreversible serious adverse reactions that have occurred together, including:
  • Tendinitis and tendon rupture
  • Peripheral neuropathy
  • Central nervous system effects (see WARNINGS).Discontinue NOROXIN immediately and avoid the use of fluoroquinolones, including NOROXIN, in patients who experience any of these serious adverse reactions.
  • Fluoroquinolones, including NOROXIN, may exacerbate muscle weakness in patients with myasthenia gravis. Avoid NOROXIN in patients with known history of myasthenia gravis (see WARNINGS).
  • Because fluoroquinolones, including NOROXIN, have been associated with serious adverse reactions (see WARNINGS), reserve NOROXIN for use in patients who have no alternative treatment options for uncomplicated urinary tract infections (including cystitis) (see INDICATIONS AND USAGE).

To reduce the development of drug-resistant bacteria and maintain the effectiveness of NOROXIN® and other antibacterial drugs, NOROXIN should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

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Grenis side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives, or the first sign of a skin rash; fast heartbeat, difficult breathing; swelling of your face, lips, tongue, or throat.

Grenis may cause swelling or tearing of (rupture) a tendon. Grenis can also have serious effects on your nerves, and may cause permanent nerve damage. Stop taking this medicine and call your doctor at once if you have:

signs of tendon rupture--sudden pain, swelling, bruising, tenderness, stiffness, movement problems, or a snapping or popping sound in any of your joints (rest the joint until you receive medical care or instructions); or

nerve symptoms--numbness, tingling, burning pain, or being more sensitive to temperature, light touch, or the sense of your body position.

Stop using Grenis and call your doctor at once if you have:

headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;

dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

muscle weakness or trouble breathing;

diarrhea that is watery or bloody;

sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, easy bruising or bleeding;

depression, confusion, hallucinations, paranoia, tremors, feeling restless or anxious, unusual thoughts or behavior, insomnia, nightmares;

seizure (convulsions); or

increased pressure inside the skull-- severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes.

Common side effects may include:

nausea, heartburn, stomach cramps, mild diarrhea;

vaginal itching or discharge;

mild dizziness; or

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Drug interactions

  • Didanosine, antacids, multivitamins, sucralfate, formulations containing iron or zinc, should not be taken within two hours of administration of Grenis.
  • Like other FQs, Grenis can lead to increase in serum levels of theophylline when prescribed simultaneously.
  • Like other FQs, Grenis may enhance the effects of oral anticoagulants.
  • Like other FQs, Grenis when given with glyburide can rarely lead to severe decrease in the plasma glucose levels.
  • Like other FQs, Grenis inhibits CYP1A2 in vitro. When used with other drugs metabolized by CYP1A2 like ropinirole, clozapine, caffeine, tizanidine, theophylline it may lead to increased substrate drug concentrations when given in normal doses.
  • Probenecid inhibits the renal elimination of Grenis thereby increasing its levels.
  • Nitrofurantion may antagonize the antibacterial effect of Grenis in the urinary tract.
  • Simultaneous prescription of Grenis with NSAIDS can lead to increased probability of convulsions.

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