Flutamerck tablets


  • Active Ingredient: Flutamide
  • 250 mg
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What is Flutamerck?

The active ingredient of Flutamerck brand is flutamide. Flutamide is an antiandrogen. It works in the body to prevent the actions of androgens (male hormones). C11H11F3N2O3 M.W. 276.21 Flutamide is a buff to yellow powder. Each capsule, for oral administration, contains 125 mg Flutamide and has the following inactive ingredients: black iron oxide, corn starch, D&C yellow #10 aluminum lake, FD&C blue #1 aluminum lake, FD&C blue #2 aluminum lake, FD&C red #40 aluminum lake, gelatin, lactose monohydrate, magnesium stearate, red iron oxide, sodium lauryl sulfate, titanium dioxide and yellow iron oxide.

Used for

Flutamerck is used to treat diseases such as: Hirsutism, Prostate Cancer.

Side Effect

Possible side effects of Flutamerck include: diarrhea; swelling; Abdominal or stomach pain; discoloration of the urine; difficulty with breathing; loss in sexual ability, desire, drive, or performance.

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How you have Flutamerck

Flutamerck is a tablet. You take it 3 times a day.

You should swallow the tablet whole with a glass of water.

Take your Flutamerck tablets after food.


Pharmacologic class: Antiandrogen

Therapeutic class: Antineoplastic

Pregnancy risk category D


EULEXIN Capsules contain Flutamerck, an acetanilid, nonsteroidal, orally active anti-androgen having the chemical name, 2-methyl-N- propanamide.

Each capsule contains 125 mg Flutamerck. The compound is a buff to yellow powder with a molecular weight of 276.2 and the following structual formula:

Flutam >

To help prevent diarrhea, avoid dairy products such as milk, cheese, and yogurt. Do not use laxatives while taking Flutamerck.

This medicine can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Other drugs may interact with Flutamerck, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Side Effects

See also Warning section.

Because Flutamerck is usually used with other medications, the side effects may be caused by the other medications or their combination. Hot flashes, loss of sexual interest/ability, diarrhea, nausea, vomiting, and enlargement of male breasts may occur. Less common side effects include drowsiness. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Diarrhea is a common side effect. Drink plenty of fluids as directed by your doctor to reduce your risk of losing too much body water. You may decrease dairy products, increase whole grains/vegetables/fruit, and stop any laxatives. Your doctor may prescribe anti-diarrhea medication (such as loperamide) to control your symptoms. Tell your doctor right away if you develop severe or persistent diarrhea or signs of dehydration (such as dizziness, decreased urination).

Flutamerck may change the color of your urine to light orange-brown or yellow-green. This is not harmful.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these rare but very serious side effects occur: mental/mood changes (such as depression, anxiety, nervousness), a breast lump, confusion, sudden severe tiredness, weakness, pale skin, bluish fingernails/lips/skin, fast heartbeat at rest, feeling short of breath at rest.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Flutamerck to Treat Prostate Cancer

The U.S. Food and Drug Administration (FDA) approved the use of Flutamerck in the country on June 1996. It is commercialized under the brand name Eulexin to be used in the therapeutic areas of endocrinology, nephrology, oncology, family medicine, and urology. The approval was based on a study submitted by the pharmaceutical company Schering-Plough, which revealed the effectiveness of Flutamerck for the treatment of locally confined Stage B2-C carcinoma of the prostate in combination with LHRH agonists and radiation therapy.

Flutamerck is prescribed as a tablet to be taken three times a day with a glass of water. Despite the encouraging results of the treatment with Flutamerck, there are also potential side effects associated to it. The most common adverse events include hot flushes and sweats, which affect three out of five men treated (60%), lowered interest in having sex (libido) and problems getting an erection (impotence), which affect about three out of 10 (30%) men but may stop after the end of the treatment, as well as breast tenderness and swelling, which occur in one out of 10 (10%) men treated.

Flutam >About Flutamerck
  • Before taking Flutamerck
  • How to take Flutamerck
  • Getting the most from your treatment
  • Can Flutamerck cause problems?
  • How to store Flutamerck
  • Important information about all medicines
  • Before taking Flutamerck

    Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking Flutamerck it is important that your doctor knows:

    • If you have any problems with the way your liver works.
    • If you have a heart condition.
    • If you have a rare inherited blood disorder called porphyria.
    • If you are taking any other medicines. This includes any medicines which are available to buy without a prescription, as well as herbal and complementary medicines.
    • If you have ever had an allergic reaction to a medicine.

    Observational studies

    Although Flutamerck is effective in treating hirsutism, adverse reactions are very frequent and long-term adherence is poor. In one study over 7 years, of 83 women who took Flutamerck 250 mg/day alone or in combination with an oral contraceptive containing ethinylestradiol 20 micrograms and desogestrel 150 micrograms, 34 had one or more adverse reaction during follow-up, 28 had at least one adverse reaction that was possibly related to the study drug, and 20 withdrew because of adverse reactions, hepatotoxicity being the most troublesome; during follow-up, as many as 59% abandoned the study .


    • Be aware that leuprolide acetate is the most common LHRH analog given with Flutamerck.


    Flutamerck may cause liver damage that can be serious or life-threatening. Tell your doctor if you have or have ever had liver disease. If you experience any of the following symptoms, call your doctor immediately: nausea, vomiting, loss of appetite, extreme tiredness, flu-like symptoms, muscle aches, soreness, pain in the upper right part of the stomach, yellowing of the skin or eyes, or dark urine.

    Keep all appointments with your doctor and the laboratory. Your doctor will order certain blood tests to check how well your liver is working before you begin taking Flutamerck, every month for the first 4 months of your treatment, and periodically for as long as your treatment continues.

    Talk to your doctor about the risks of taking Flutamerck.

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