Doxagamma belongs to a group of medicines known as alpha-blockers. It works by blocking the action of certain nerve impulses. This blocking action is useful in two different medical conditions. It is used to help control the symptoms of prostate gland enlargement, and it also reduces blood pressure in people with hypertension.
Serious Side Effects of Doxagamma
Serious side effects of Doxagamma may include:
- Hives or other signs of an allergic reaction
- Feeling like you might pass out
- Pounding heartbeat
- Trouble breathing
- Swelling in the ankles, hands, or feet
- Vision changes
- Slurred speech
- Erection that is painful or lasts 4 hours or longer
You should seek medical help right away if you experience a serious side effect.
Plasma elimination of Doxagamma is biphasic, with a terminal elimination half-life of about 22 hours. Steady-state studies in hypertensive patients given Doxagamma doses of 2 to 16 mg once daily showed linear kinetics and dose proportionality. In two studies, following the administration of 2 mg orally once daily, the mean accumulation ratios (steady-state AUC vs. first-dose AUC) were 1.2 and 1.7. Enterohepatic recycling is suggested by secondary peaking of plasma Doxagamma concentrations.
In a study of two subjects administered radiolabelled Doxagamma 2 mg orally and 1 mg intravenously on two separate occasions, approximately 63% of the dose was eliminated in the feces and 9% of the dose was found in the urine. On average only 4.8% of the dose was excreted as unchanged drug in the feces and only a trace of the total radioactivity in the urine was attributed to unchanged drug.
Blood pressure medications
Combining Doxagamma with any drug that lowers your blood pressure can increase your risk for lowering your blood pressure too much. Examples of drugs that lower your blood pressure are:
- aldosterone antagonists, such as spironolactone and eplerenone
- angiotensin-converting enzyme (ACE) inhibitors, such as benazepril, lisinopril, enalapril, and fosinopril
- angiotensin receptor blockers (ARBs), such as losartan, candesartan, and valsartan
- beta-blockers, such as atenolol, bisoprolol, metoprolol, and propranolol
- calcium channel blockers such as amlodipine, nifedipine, nicardipine, diltiazem, and verapamil
- centrally acting adrenergic agents, such as clonidine, guanfacine, and methyldopa
- direct renin inhibitors, such as aliskiren
- diuretics such as amiloride, chlorthalidone, furosemide, and metolazone
- vasodilators such as hydralazine and minoxidil
- nitrates, such as isosorbide mononitrate, isosorbide dinitrate, and nitroglycerin transdermal patch
Combining Doxagamma with drugs that increase your blood pressure can cancel the effects of both medications. Examples of these drugs include:
- symphathomimetics (decongestants) such as pseudoephedrine, oxymetazoline, phenylephrine
- erythropoiesis-stimulating agents (red blood cell production stimulators) such as darbepoetin alfa and epoetin alfa
- contraceptives (birth control) such as ethinyl estradiol and ethinyl estradiol/levonorgestrel
Common Side Effects of Doxagamma
Some common, less serious side effects of Doxagamma may include:
- Mild dizziness
- Runny nose
- Weight gain
- Feeling tired or drowsy
Older adults may be more sensitive to the side effects of Doxagamma, which can increase the risk of falling.
Which drugs or supplements interact with Doxagamma mesylate?
Vardenafil (Levitra) or tadalafil (Cialis) and Doxagamma have additive blood pressure lowering effects. Combining vardenafil or tadalafil (Cialis) with Doxagamma may cause excessive blood pressure reduction.
Warnings for other groups
For pregnant women: The extended-release form of Doxagamma is not meant for use in women. The immediate-release form of the drug can be used in women. However, there haven’t been enough studies done in humans to be certain how Doxagamma might affect a fetus during pregnancy.
Tell your doctor if you’re pregnant or plan to become pregnant. Doxagamma should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
For women who are breastfeeding: Doxagamma passes through breast milk. You and your doctor may need to decide whether you’ll take this medication or breastfeed.
For seniors: This medication should be used cautiously in people aged 65 years and older. If you’re 65 or older, you’re at increased risk of having low blood pressure when you stand up. This can lead to dizziness and lightheadedness.
For children: The safety and effectiveness of Doxagamma haven’t been established in people younger than 18 years old for.
This dosage information is for Doxagamma oral tablet. All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:
- your age
- the condition being treated
- how severe your condition is
- other medical conditions you have
- how you react to the first dose
Attention deficit hyperactivity disorder (ADHD) drug
Taking methylphenidate with Doxagamma can decrease the effect of Doxagamma. This may cause your blood pressure to stay too high.
How to use Doxagamma MESYLATE
Read the Patient Information Leaflet if available from your pharmacist before you start taking Doxagamma and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth with or without food as directed by your doctor, usually once daily.
Doxagamma may cause a sudden drop in your blood pressure, which could lead to dizziness or fainting, usually within 2 to 6 hours after you take it. This risk is higher when you first start taking this drug, after your doctor increases your dose, or if you restart treatment after you stop taking it. During these times, avoid situations where you may be injured if you faint.
To avoid injury related to dizziness or fainting, take your first dose of Doxagamma at bedtime unless otherwise directed by your doctor. Your doctor will start this medication at a low dose and gradually increase your dose. Any time your dose is increased or if you restart treatment after you have stopped it, take your first dose at bedtime unless otherwise directed. Follow your doctor's instructions carefully.
The dosage is based on your medical condition and response to treatment.
Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. If you miss taking Doxagamma for a few days, you may need to restart treatment at the low dose and gradually increase your dose again. Consult your doctor for more details.
It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick.
You should see a benefit from this drug within 1 to 2 weeks. Tell your doctor if your condition does not improve or if it worsens (for example, your blood pressure readings remain high or increase, or your BPH symptoms worsen).
What other drugs will affect Doxagamma?
Tell your doctor about all your current medicines and any you start or stop using, especially:
medicine to treat HIV or AIDS; or
sildenafil (Viagra) or other erectile dysfunction medicines.
This list is not complete. Other drugs may interact with Doxagamma, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
COMMON BRAND(S): Cardura
GENERIC NAME(S): Doxagamma
Doxagamma is used alone or with other drugs to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication works by relaxing blood vessels so blood can flow more easily.
Doxagamma is also used in men to treat the symptoms of an enlarged prostate (benign prostatic hyperplasia-BPH). It does not shrink the prostate, but it works by relaxing the muscles in the prostate and part of the bladder. This helps to relieve symptoms of BPH such as difficulty in beginning the flow of urine, weak stream, and the need to urinate frequently or urgently (including during the middle of the night).
Doxagamma belongs to a class of drugs known as alpha blockers.
Typical Dose for Adults with High Blood Pressure
Initial dose: 1 milligram (mg), once a day at bedtime
Maintenance dose: 1 mg to 16 mg, once a day
Typical Dose for Adults with Enlarged Prostate
Immediate-release: 1 milligram (mg), once a day at bedtime
Extended-release: 4 mg, once a day with breakfast
Immediate-release: 1 mg to 8 mg, once a day at bedtime
Extended-release: 4 mg to 8 mg once a day with breakfast
Some drugs that may interact with Doxagamma include:
- Erectile dysfunction medicines, including sildenafil (Viagra, Revatio), tadalafil (Cialis), and vardenafil (Levitra)
- Hepatitis C protease inhibitor (Boceprevir)
- Monoamine oxidase inhibitors (MAOIs), such as phenelzine (Nardil) and tranylcypromine (Parnate)
You should tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs you are taking.
ВїCГіmo se debe usar este medicamento?
La Doxagammaa viene envasada en forma de tabletas y tabletas de liberaciГіn lenta para tomar por vГa oral. Las tabletas de Doxagammaa por lo general se toman con o sin alimentos una vez al dГa en la maГ±ana o en la noche. Las tabletas de liberaciГіn lenta se toman por lo general una vez al dГa con el desayuno. Tome la Doxagammaa a la misma hora todos los dГas. Siga cuidadosamente las instrucciones en la etiqueta del medicamento y pregГєntele a su doctor o farmacГ©utico cualquier cosa que no entienda. Use el medicamento exactamente como se indica. No use mГЎs ni menos que la dosis indicada ni tampoco mГЎs seguido que lo prescrito por su doctor.
Tome las tabletas de liberaciГіn lenta enteras; no las divida, mastique ni triture.
Su doctor podrГa comenzar con una dosis baja y aumentarla de manera gradual, pero no mГЎs de una vez cada 1 Гі 2 semanas. Si usted deja de tomar este medicamento por algunos dГas o por mГЎs tiempo, llame a su doctor. Su doctor tendrГЎ que comenzar nuevamente con la dosis mГЎs baja de Doxagammaa y aumentarla de manera gradual.
La Doxagammaa controla la hipertensiГіn y los sГntomas de la prГіstata agrandada, pero no las cura. Puede tomar unas pocas semanas antes de que usted sienta el beneficio total de tomar Doxagammaa. ContinГєe con el medicamento aunque se sienta mejor y no deje de tomarlo sin antes consultarlo con su mГ©dico.
Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
- Heart problems such as chest pain or rapid, pounding, or irregular heartbeat
- Priapism (painful erection that lasts for hours)
- chest tightness
- swelling of your face, lips, tongue, or throat
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
Doxagamma oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Examples of drugs that can cause interactions with Doxagamma are listed below.
How should I take Doxagamma?
Take Doxagamma exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Doxagamma lowers blood pressure and may cause dizziness or fainting, especially when you first start taking it, or when you start taking it again.
You may feel very dizzy when you first wake up. Be careful when standing or sitting up from a lying position.
Call your doctor if you have severe dizziness or feel like you might pass out.
While using Doxagamma, your blood pressure or prostate may need to be checked often.
If you stop taking Doxagamma for any reason, ask your doctor before you start taking it again. You may need a dose adjustment.
If you are being treated for high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.
Store at room temperature away from moisture and heat.
Rated Doxagamma for Hypertension Report
started with 2MG (MYLAN) for hypertension, blood pressure numbers dropped from 170/110 to 130/80 average so far 5 days after initial. also just a side note. this is with three other BP meds, Catapres patch .3, Amlodipine 10MG and Avapro 300MG.
Doxagamma side effects
Get emergency medical help if you have signs of an allergic reaction to Doxagamma: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
a light-headed feeling, like you might pass out;
severe ongoing stomach pain or bloating;
new or worsening chest pain;
trouble breathing; or
a penis erection that is painful or lasts 4 hours or longer.
Common Doxagamma side effects may include:
low blood pressure, dizziness;
feeling weak or tired.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.