Doxagal tablets

Doxagal

  • Active Ingredient: Doxazosin
  • 4 mg, 2 mg, 1 mg
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What is Doxagal?

The active ingredient of Doxagal brand is doxazosin. Doxazosin is an alpha-adrenergic (AL-fa ad-ren-ER-jik) blockers. Doxazosin relaxes your veins and arteries so that blood can more easily pass through them. It also relaxes the muscles in the prostate and bladder neck, making it easier to urinate.

Used for

Doxagal is used to treat diseases such as: Benign Prostatic Hyperplasia, High Blood Pressure, Raynaud's Syndrome.

Side Effect

Possible side effects of Doxagal include: Headache; shortness of breath; fainting (sudden); painful urination; muscle aching, cramping, or weakness; muscle pains or stiffness; bladder pain.

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Before taking Doxagal

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking Doxagal it is important that your doctor knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you ever feel dizzy or faint when you stand up, or if you have ever fainted after passing urine.
  • If you are due to have cataract eye surgery.
  • If you have any problems with the way your liver works.
  • If you have been told you have heart failure.
  • If you have ever had an allergic reaction to a medicine.
  • If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.

Warnings for other groups

For pregnant women: The extended-release form of Doxagal is not meant for use in women. The immediate-release form of the drug can be used in women. However, there haven’t been enough studies done in humans to be certain how Doxagal might affect a fetus during pregnancy.

Tell your doctor if you’re pregnant or plan to become pregnant. Doxagal should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

For women who are breastfeeding: Doxagal passes through breast milk. You and your doctor may need to decide whether you’ll take this medication or breastfeed.

For seniors: This medication should be used cautiously in people aged 65 years and older. If you’re 65 or older, you’re at increased risk of having low blood pressure when you stand up. This can lead to dizziness and lightheadedness.

For children: The safety and effectiveness of Doxagal haven’t been established in people younger than 18 years old for.

This dosage information is for Doxagal oral tablet. All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

Doxagal and Pregnancy

It's not known whether Doxagal will harm an unborn baby. You should tell your doctor if you are pregnant or might become pregnant while taking this medication.

It's also not known whether the drug passes into breast milk or if it could harm a breastfeeding baby.

After oral administration of therapeutic doses, peak plasma levels of CARDURA occur at about 2–3 hours. Bioavailability is approximately 65%, reflecting first-pass metabolism of Doxagal by the liver. The effect of food on the pharmacokinetics of CARDURA was examined in a crossover study with twelve hypertensive subjects. Reductions of 18% in mean maximum plasma concentration (Cmax) and 12% in the area under the concentration-time curve (AUC) occurred when CARDURA was administered with food. Neither of these differences is clinically significant.

In a crossover study in 24 normotensive subjects, the pharmacokinetics and safety of Doxagal were shown to be similar with morning and evening dosing regimens. The AUC after morning dosing was, however, 11% less than that after evening dosing and the time to peak concentration after evening dosing occurred significantly later than that after morning dosing (5.6 vs. 3.5 hours).

CARDURA is extensively metabolized in the liver, mainly by O-demethylation of the quinazoline nucleus or hydroxylation of the benzodioxan moiety. In vitro studies suggest that the primary pathway for elimination is via CYP 3A4; however, CYP 2D6 and CYP 2C9 metabolic pathways are also involved to a lesser extent. Although several active metabolites of Doxagal have been identified, the pharmacokinetics of these metabolites have not been characterized.

In a pooled analysis of placebo-controlled hypertension studies with about 300 hypertensive patients per treatment group, Doxagal, at doses of 1 to 16 mg given once daily, lowered blood pressure at 24 hours by about 10/8 mmHg compared to placebo in the standing position and about 9/5 mmHg in the supine position. Peak blood pressure effects (1–6 hours) were larger by about 50–75% (i.e., trough values were about 55–70% of peak effect), with the larger peak-trough differences seen in systolic pressures. There was no apparent difference in the blood pressure response of Caucasians and blacks or of patients above and below age 65. In the same patient population, patients receiving CARDURA gained a mean of 0.6 kg compared to a mean loss of 0.1 kg for placebo patients.

TABLE 4 : Mean Changes in Blood Pressure from Baseline to the Mean of the Final Efficacy Phase in Normotensives (Diastolic BP

Warnings

  • This medication contains Doxagal. Do not take Cardura, Cardura XL, or Doxadura if you are allergic to Doxagal or any ingredients contained in this drug.
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Cancer drug

Taking amifostine with Doxagal increases your risk of low blood pressure.

Contraindications

  • Hypersensitivity to doxasozin or other quinazolines.

Effects of Drug Abuse

No information provided.

  • See "What Are Side Effects Associated with Using Doxagal?"

  • See "What Are Side Effects Associated with Using Doxagal?"

  • Use with caution in liver disease or recent stroke (cerebrovascular accident )
  • Rule outprostate cancer before initiating therapy
  • May cause first-dose fainting or sudden loss of consciousness
  • Risk of dizziness upon standing (dose dependent)
  • Potential for low blood pressure, dry mouth, and urinary complications in elderly
  • Priapism (painful penile erection, sustained for hours and unrelieved by sexual intercourse or masturbation) rarely reported (probably less frequently than once in every several thousand patients), with alpha-1 antagonists, including Doxagal; because condition can lead to permanent impotence if not promptly treated, patients must be advised about seriousness of condition
  • Concomitant use of other antihypertensives (additive hypotensive effects)
  • Extended-release form not indicated for high blood pressure
  • Concomitant administration of immediate-release form with a phosphodiesterase-5 (PDE-5) inhibitor can result in additive blood pressure lowering effects and symptomatichypotension
  • May increase the risk of heart failure by exacerbating underlying myocardial dysfunction by beta-1Receptor stimulation with increases in renin and aldosterone

  • Doxagal is not indicated for use in females or for the treatment of hypertension. The limited available data in pregnant women are not sufficient to inform a drug-associated risk for major birth defects and miscarriage
  • No adverse developmental outcomes were observed in animal reproduction studies with oral administration to pregnant rats and rabbits at doses of up to 10 and 4 times, respectively, the 12 mg/day recommended dose; postnatal development was delayed in rats at a dose of 8 times the 12 mg/day recommended dose
  • Doxagal is present in human milk; there is no information on effects on breastfed infants or effects on milk production when breastfeeding

Before taking this medicine

You should not use this medicine if you are allergic to Doxagal or similar medicines such as alfuzosin (Uroxatral), prazosin (Minipress), silodosin (Rapaflo), tamsulosin (Flomax), or terazosin (Hytrin).

To make sure Doxagal is safe for you, tell your doctor if you have:

a blockage in your digestive tract (stomach or intestines);

liver disease; or

low blood pressure.

Doxagal can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Do not stop using this medicine before surgery unless your surgeon tells you to.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether Doxagal passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Common Side Effects of Doxagal

Some common, less serious side effects of Doxagal may include:

  • Mild dizziness
  • Nausea
  • Runny nose
  • Headache
  • Weight gain
  • Feeling tired or drowsy

Older adults may be more sensitive to the side effects of Doxagal, which can increase the risk of falling.

Before taking Doxagal,

  • tell your doctor and pharmacist if you are allergic to Doxagal, prazosin (Minipress), terazosin, any other medications, or any ingredients in Doxagal tablets or extended-release tablets. Ask your pharmacist for a list of the ingredients..
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antihistamines; clarithromycin (Biaxin, in Prevpac); ipratropium (Atrovent, in Combivent); itraconazole (Onmel, Sporanox); ketoconazole (Nizoral); medications for erectile dysfunction (ED) such as sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), or vardenafil (Levitra, Staxyn); medications for high blood pressure; medications for HIV/AIDS including atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), or saquinavir (Invirase); medications for irritable bowel disease, motion sickness, Parkinson's disease, ulcers, or urinary problems; nefazodone; telithromycin (Ketek); and voriconazole (Vfend). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have angina (chest pain); low blood pressure; if you have ever had low blood pressure after taking a medication; or if you have or have ever had prostate cancer, or liver disease. If you are taking the extended-release tablet, tell you doctor if you have constipation, short bowel syndrome (a condition where more than half of the small intestine has been removed by surgery or damaged by disease), or narrowing or a blockage of the intestines.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Doxagal, call your doctor.
  • talk to your doctor about the risks and benefits of taking Doxagal if you are 65 years of age or older. Older adults should not usually take Doxagal to treat high blood pressure, because it is not as safe as other medications that can be used to treat the same condition.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Doxagal. If you need to have eye surgery at any time during or after your treatment, be sure to tell your doctor that you are taking or have taken Doxagal.
  • you should know that Doxagal may make you drowsy or dizzy. Do not drive a car, operate machinery, or perform dangerous tasks for 24 hours after the first time you take Doxagal or after your dose is increased.
  • you should know that Doxagal may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking Doxagal, when your dose is increased, or if your treatment has been stopped for more than a few days. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. If you experience these symptoms, sit or lie down. If these symptoms do not improve, call your doctor.

Doxagal Dosage

Typical Dose for Adults with High Blood Pressure

Initial dose: 1 milligram (mg), once a day at bedtime

Maintenance dose: 1 mg to 16 mg, once a day

Typical Dose for Adults with Enlarged Prostate

Immediate-release: 1 milligram (mg), once a day at bedtime

Extended-release: 4 mg, once a day with breakfast

Maintenance dose:

Immediate-release: 1 mg to 8 mg, once a day at bedtime

Extended-release: 4 mg to 8 mg once a day with breakfast

What Other Drugs Interact with Doxagal?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Severe interactions of Doxagal include:

Serious interactions of Doxagal include:

Mild interactions of Doxagal include:

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

Rated Doxagal for Hypertension Report

The drug does everything the doctor said it would, including lowering BP and decreasing prostate problems. However, it seems to build up in my system after a few continuous days of treatment and causes me to have extreme fatigue. In fact, I can hardly go an hour during a day without lying down and falling asleep for an hour or so. The feeling is overwhelming and makes me essentially dysfunctional. Quiet activities such as reading or watching TV are impossible without falling asleep. I take only 2 mg at night.

What other drugs will affect Doxagal?

Tell your doctor about all your current medicines and any you start or stop using, especially:

medicine to treat HIV or AIDS; or

sildenafil (Viagra) or other erectile dysfunction medicines.

This list is not complete. Other drugs may interact with Doxagal, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What is the dosage for Doxagal mesylate?

The recommended dose of Doxagal for hypertension is 1-16 mg daily. The recommended dose for benign prostatic hyperplasia is 1-8 mg daily.

Rated Doxagal for Benign Prostatic Hyperplasia (BPH) Report

8mg caused sinus issues,2mg dosage right or me


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