Chibroxol tablets


  • Active Ingredient: Norfloxacin
  • 400 mg
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What is Chibroxol?

The active ingredient of Chibroxol brand is norfloxacin. The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content.

Used for

Chibroxol is used to treat diseases such as: Bladder Infection, Campylobacter Gastroenteritis, Epididymitis, Non-Specific, Gonococcal Infection, Uncomplicated, Kidney Infections, Prostatitis, Salmonella Enteric Fever, Salmonella Gastroenteritis, Shigellosis, Traveler's Diarrhea, Urinary Tract Infection.

Side Effect

Possible side effects of Chibroxol include: red, irritated eyes; false sense of well-being; Acid or sour stomach; weakness in the arms, hands, legs, or feet; muscle weakness; increased hunger; trouble with concentrating; sore throat.

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What should I discuss with my healthcare provider before taking Chibroxol?

You should not use this medication if you are allergic to Chibroxol, or if:

you have ever had swelling or tearing of a tendon caused by taking Chibroxol or similar antibiotics; or

you are allergic to other fluoroquinolones (ciprofloxacin, gemifloxacin, levofloxacin, moxifloxacin, ofloxacin, and others).

You may not be able to use Chibroxol if you have a muscle disorder. Tell your doctor if you have a history of myasthenia gravis.

To make sure Chibroxol is safe for you, tell your doctor if you have:

a heart rhythm disorder, especially if you take medication to treat it;

slow heartbeats, or a personal or family history of Long QT syndrome;

tendon problems, arthritis or other joint problems;

a muscle or nerve disorder;

kidney or liver disease;

seizures or epilepsy;

a history of head injury or brain tumor;

a history of allergic reaction to an antibiotic;

diabetes (especially if you take oral diabetes medication);

low levels of potassium in your blood (hypokalemia); or

if you use a blood thinner (warfarin, Coumadin) and have "INR" or prothrombin time tests.

Chibroxol may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. This can happen during treatment or up to several months after you stop taking Chibroxol. Tendon problems may be more likely to occur if you are over 60, if you take steroid medication, or if you have had a kidney, heart, or lung transplant.

FDA pregnancy category C. It is not known whether Chibroxol will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether Chibroxol passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

C Role of DNA Gyrase in the Quinolone–DNA Interaction

The key experimental ev >Chibroxol binding to the enzyme–DNA complexes ( Shen et al., 1989a ). It was found that the binding of the drug to relaxed forms of DNA may be induced by the addition of DNA gyrase, and that the amount of the binding to the enzyme–DNA complex is far more than the sum of the separated bindings to the DNA and to the enzyme. The increased drug binding was not due to the conversion of the substrate DNA to the supercoiled form, since nonhydrolyzable triphosphate nucleotide was used in the binding mixture. As shown in Fig. 5 , the induced binding to the gyrase–DNA complex showed a saturable phase that highly resembles the binding pattern to the supercoiled DNA in terms of the amount of binding and the binding cooperativity ( Shen et al., 1989b ). When linear DNA was used, the specific type of binding may be obtained without requiring a nucleotide energy source. It is conceivable that the open DNA ends do not restrict the DNA conformational change or DNA unwinding that is necessary for the creation of the drug binding site during the enzyme-wrapping and gate-opening steps following the DNA cleavage. ATP was known to strikingly enhance DNA cleavage and change the gyrase cleavage sites on DNA ( Morrison et al., 1980 ); thus, the ATP-dependent binding phenomenon may be site specific. Above results suggested that the binding of DNA gyrase to the DNA substrate creates a specific site that allows the drug to bind in a cooperative manner.


  • This medicine may cause severe side effects like irritated or torn tendons; nerve problems in the arms, hands, legs, or feet; and nervous system problems. These can happen alone or at the same time. They can happen within hours to weeks after starting Chibroxol. Some of these effects may not go away, and may lead to disability or death.
  • The chance of irritated or torn tendons is greater in people over the age of 60; heart, kidney, or lung transplant patients; or people taking steroid drugs. Tendon problems can happen as long as several months after treatment. Call your doctor right away if you have pain, bruising, or swelling in the back of the ankle, shoulder, hand, or other joints. Call your doctor right away if you are not able to move or bear weight on a joint or if you hear or feel a snap or pop.
  • Call your doctor right away if you have signs of nerve problems. These may include not being able to handle heat or cold; change in sense of touch; or burning, numbness, tingling, pain, or weakness in the arms, hands, legs, or feet.
  • Call your doctor right away if you have signs of nervous system problems. These may include anxiety, bad dreams, trouble sleeping, change in eyesight, dizziness, feeling confused, feeling nervous or agitated, feeling restless, hallucinations (seeing or hearing things that are not there), new or worse behavior or mood changes like depression or thoughts of killing yourself, seizures, or very bad headaches.
  • Do not take if you have myasthenia gravis. Very bad and sometimes deadly breathing problems have happened with Chibroxol in people who have myasthenia gravis.
  • For some health problems, Chibroxol is only for use when other drugs cannot be used or have not worked. Talk with the doctor to be sure that the benefits of Chibroxol are more than the risks.

What are some other side effects of Chibroxol?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Headache.
  • Dizziness.
  • Upset stomach or throwing up.
  • Diarrhea.
  • Constipation.
  • Not hungry.
  • Feeling sleepy.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at

Absorption and distribution

Chibroxol displays linear kinetics. There is no significant accumulation with the recommended dosage of 400 mg every 12 h. Food slightly delays but does not otherwise impair absorption. Antacids reduce absorption. It is widely distributed, but concentrations in tissues other than those of the urinary tract are low; levels in the prostate are around 2.5 mg/g.

Pregnancy Category C. Chibroxol has been shown to produce embryonic loss in monkeys when given in doses 10 times2 the maximum daily total human dose (on a mg/kg basis). At this dose, peak plasma levels obtained in monkeys were approximately 2 times those obtained in humans. There has been no evidence of a teratogenic effect in any of the animal species tested (rat, rabbit, mouse, monkey) at 6-50 times2 the maximum daily human dose (on a mg/kg basis). There are, however, no adequate and well-controlled studies in pregnant women. Chibroxol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.


GENERIC NAME(S): Chibroxol

Quinolone antibiotics (including Chibroxol) may cause serious and possibly permanent tendon damage (such as tendonitis, tendon rupture), nerve problems in the arms and legs (peripheral neuropathy), and nervous system problems. Get medical help right away if you have any of the following symptoms: pain/numbness/burning/tingling/weakness in your arms/hands/legs/feet, changes in how you sense touch/pain/temperature/vibration/body position, severe/lasting headache, vision changes, shaking (tremors), seizures, mental/mood changes (such as agitation, anxiety, confusion, hallucinations, depression, rare thoughts of suicide).

Tendon damage may occur during or after treatment with this medication. Stop exercising, rest, and get medical help right away if you develop joint/muscle/tendon pain or swelling. Your risk for tendon problems is greater if you are over 60 years of age, if you are taking corticosteroids (such as prednisone), or if you have a kidney, heart, or lung transplant.

This medication may make a certain muscle condition (myasthenia gravis) worse. Tell your doctor right away if you have new or worsening muscle weakness (such as drooping eyelids, unsteady walk) or trouble breathing.

Discuss the risks and benefits with your doctor before using this medication.

Chibroxol is used to treat a variety of bacterial infections. This medication belongs to a class of drugs known as quinolone antibiotics. It works by stopping the growth of bacteria.

This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.

What is Chibroxol? What is Chibroxol used for?

Chibroxol is a fluoroquinolone antibiotic. Other fluoroquinolones include ciprofloxacin (Cipro), levofloxacin (Levaquin), and ofloxacin (Floxin). Chibroxol works by blocking DNA gyrase enzyme, which is responsible for production and repair of bacterial DNA. Blocking of DNA gyrase leads to bacteria death and prevents worsening of infection. Chibroxol treats infections caused by gram-positive and gram-negative bacteria like Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus saprophyticus, Streptococcus agalactiae, Citrobacter freundii, Enterobacter aerogenes, Enterobacter cloacae, Escherichia coli, Klebsiella pneumonia, Neisseria gonorrhoeae, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa, and Serratia marcescens. FDA approved the brand name Chibroxol (Noroxin) in October 1986.


Pharmacologic class: Fluoroquinolone

Therapeutic class: Anti-infective

Pregnancy risk category C

Chibroxol side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives, or the first sign of a skin rash; fast heartbeat, difficult breathing; swelling of your face, lips, tongue, or throat.

Chibroxol may cause swelling or tearing of (rupture) a tendon. Chibroxol can also have serious effects on your nerves, and may cause permanent nerve damage. Stop taking this medicine and call your doctor at once if you have:

signs of tendon rupture--sudden pain, swelling, bruising, tenderness, stiffness, movement problems, or a snapping or popping sound in any of your joints (rest the joint until you receive medical care or instructions); or

nerve symptoms--numbness, tingling, burning pain, or being more sensitive to temperature, light touch, or the sense of your body position.

Stop using Chibroxol and call your doctor at once if you have:

headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;

dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

muscle weakness or trouble breathing;

diarrhea that is watery or bloody;

sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, easy bruising or bleeding;

depression, confusion, hallucinations, paranoia, tremors, feeling restless or anxious, unusual thoughts or behavior, insomnia, nightmares;

seizure (convulsions); or

increased pressure inside the skull-- severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes.

Common side effects may include:

nausea, heartburn, stomach cramps, mild diarrhea;

vaginal itching or discharge;

mild dizziness; or

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Special populations

It is a Category C drug. Animal studies have not shown any teratogenic effect.

It is not known whether Chibroxol is secreted during lactation.

There are no studies regarding the safety of Chibroxol in persons aged

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