Casomax tablets

Casomax

  • Active Ingredient: Bicalutamide
  • 50 mg
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What is Casomax?

The active ingredient of Casomax brand is bicalutamide. Bicalutamide is an anti-androgen. It works in the body by preventing the actions of androgens (male hormones). Bicalutamide has a molecular weight of 430.37. The pKa' is approximately 12. Bicalutamide is a fine white to off-white powder which is practically insoluble in water at 37В°C (5 mg per 1000 mL), slightly soluble in chloroform and absolute ethanol, sparingly soluble in methanol, and soluble in acetone and tetrahydrofuran. Bicalutamide is a racemate with its antiandrogenic activity being almost exclusively exhibited by the R-enantiomer of Bicalutamide; the S-enantiomer is essentially inactive. The inactive ingredients of Bicalutamide tablets, USP are lactose monohydrate, magnesium stearate, hypromellose E5, polyethylene glycol 400, povidone K 30, sodium starch glycolate, and titanium dioxide. Bicalutamide tablets, USP 50 mg meets USP Dissolution Test 2.

Used for

Casomax is used to treat diseases such as: Prostate Cancer.

Side Effect

Possible side effects of Casomax include: sweating; leg cramps; lightheadedness; difficulty with swallowing or eating; body aches or pain; decreased interest in sexual intercourse; painful or difficult urination.

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Find out what Casomax is, how you have it and other important information about having Casomax.

Casomax is a cancer treatment drug and is also known by its brand name, Casodex.

It is a treatment for prostate cancer.

Pharmacokinetics

Casomax is well-absorbed following oral administration, although the absolute bioavailability is unknown. Co-administration of Casomax with food has no clinically significant effect on rate or extent of absorption.

Bicalutam >DRUG INTERACTIONS ( 7)].

Casomax undergoes stereospecific metabolism. The S (inactive) isomer is metabolized primarily by glucuronidation. The R (active) isomer also undergoes glucuronidation but is predominantly oxidized to an inactive metabolite followed by glucuronidation. Both the parent and metabolite glucuronides are eliminated in the urine and feces. The S-enantiomer is rapidly cleared relative to the R-enantiomer, with the R-enantiomer accounting for about 99% of total steady-state plasma levels.

Pharmacokinetics of the active enantiomer of Casomax in normal males and patients with prostate cancer are presented in Table 3.

More About Bicalutam >Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug.

MedlinePlus Information on Casomax - A lay language summary of important information about this drug that may include the following:

  • warnings about this drug,
  • what this drug is used for and how it is used,
  • what you should tell your doctor before using this drug,
  • what you should know about this drug before using it,
  • other drugs that may interact with this drug, and
  • possible s >Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.

Dosage Adjustment In Hepatic Impairment

No dosage adjustment is necessary for patients with mild to moderate hepatic impairment. In patients with severe liver impairment (n=4), although there was a 76% increase in the half-life (5.9 and 10.4 days for normal and impaired patients, respectively) of the active enantiomer of Casomax, no dosage adjustment is necessary .

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In prostate cancer, the cancer cells need the male hormone testosterone to grow and multiply well. Hormone treatments like Casomax block the effect of testosterone on prostate cancer cells. This slows down the growth of the cancer. Casomax also helps to reduce symptom 'flares' and side-effects from other treatments which may be used for the cancer, or following surgery.

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Casomax is a hormonal therapy drug used to treat prostate cancer. It is best to read this information with our general information about hormonal therapies and the type of cancer you have.

Casomax is given as tablets. Your cancer doctor, nurse or pharmacist will tell you how often you will have it.

Like all cancer drugs, Casomax can cause side effects. Some of the side effects can be serious, so it is important to read the detailed information below.

Your healthcare team can give you advice on how to manage any side effects. Tell your doctor or nurse straight away if you feel unwell or have severe side effects, including any we do not mention here.

Rarely, side effects may be life-threatening. Your cancer doctor or nurse can explain the risk of these side effects to you.

If you need medical attention for any reason other than cancer, always tell the healthcare staff that you are having this treatment.

How should I take Casomax (Casodex)?

Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Casomax is usually taken once per day in the morning or evening. You may take the medicine with or without food. Try to take the medication at the same time each day.

Casomax is given as part of a combination prostate cancer treatment with another medicine called a luteinizing (LOO-tee-in-ize-ing) hormone-releasing hormone, or LHRH. These medicines prevent the testicles from producing testosterone.

Treatment with Casomax and LHRH is usually started at the same time. Follow your doctor's instructions.

LHRH is given as an injection or a tiny implant injected through a needle under the skin around your navel. LHRH injections are given at intervals such as once every 4 weeks. Follow your doctor's instructions.

You should not stop using Casomax unless your doctor tells you to.

While using Casomax, you may need frequent blood tests.

Store at room temperature away from moisture and heat.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Important: Casomax can sometimes cause other side-effects such as breathing problems and allergic reactions. Although these occur less commonly than the ones listed above, they are symptoms that you should tell your doctor about as soon as possible.

If you experience any other symptoms which you think may be due to the tablets, please speak with your doctor or pharmacist for further advice.

Dosage Forms And Strength

CASODEX ® (Casomax) 50 mg tablets for oral administration.

White, film-coated tablets (identified on one side with "CDX50" and on the reverse with the "CASODEX logo") are supplied in unit dose bottles of 30 tablets (0310-0705-30).

Before taking Casomax,

  • tell your doctor and pharmacist if you are allergic to Casomax, any other medications, or any of the ingredients in Casomax tablets. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: alprazolam (Xanax); anticoagulants ('blood thinners') such as warfarin (Coumadin); aripiprazole (Abilify); buspirone (Buspar); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac), felodipine (Plendil), nifedipine (Adalat, Procardia), nisoldipine (Sular), and verapamil (Calan, Covera, Isoptin, Verelan); chlorpheniramine; cholesterol-lowering medications (statins) such as atorvastatin (Lipitor), lovastatin (Mevacor), and simvastatin (Zocor); clarithromycin (Biaxin); cyclosporine (Neoral, Sandimmune); diazepam (Valium); erythromycin (E.E.S., E-Mycin, Erythrocin); HIV protease inhibitors such as indinavir (Crixivan), ritonavir (Norvir), and saquinavir (Invirase, Fortovase); methadone (Dolophine); midazolam (Versed); pimozide (Orap); quinidine (Quinidex, Quinaglute); quinine; sildenafil (Viagra); tacrolimus (Prograf); tamoxifen (Nolvadex); telithromycin (Ketek); trazodone (Desyrel); triazolam (Halcion); and vincristine (Vincasar). Many other medications may also interact with Casomax, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
  • tell your doctor if you have or have ever had liver disease.
  • you should know that Casomax is only for use in men. If taken by pregnant women, Casomax can cause abnormalities in the fetus. Women who are or may become pregnant should not take Casomax. If you take Casomax while you are pregnant, call your doctor immediately.

Bicalutam > Casomax is a non-steroidal androgen receptor inhibitor. It competitively inhibits the action of androgens by binding to cytosol androgen receptors in the target tissue. Prostatic carcinoma is known to be androgen sensitive and responds to treatment that counteracts the effect of androgen and/or removes the source of androgen.

When Casomax is combined with LHRH analog therapy, the suppression of serum testosterone induced by the LHRH analog is not affected. However, in clinical trials with Casomax as a single agent for prostate cancer, rises in serum testosterone and estradiol have been noted.

In a subset of patients who have been treated with Casomax and an LHRH agonist, and who discontinue Casomax therapy due to progressive advanced prostate cancer, a reduction in Prostate Specific Antigen (PSA) and/or clinical improvement (antiandrogen withdrawal phenomenon) may be observed.

ChemoExperts Tips

  • Gynecomastia (swelling of the breast tissue) has mostly been reported in trials of Casomax using the 150 mg daily dose. The frequency of gynecomastia with 50 mg daily is rare
  • Casomax may be given days or weeks before starting an injectable medication known as a LHRH agonist (example: leuprolide acetate, Lupron® or Eligard®). The timing is important to prevent tumor flare.
  • A pharmacist should ALWAYS review your medication list to ensure that drug interactions are prevented or managed appropriately
  • Clinical trials may exist for prostate cancer. Ask your doctor if any studies are currently enrolling in your area. If not, go to clinicaltrials.gov to search for other centers offering study medications

Renal Impairment

Renal impairment (as measured by creatinine clearance) had no significant effect on the elimination of total Casomax or the active R-enantiomer.

Lactation

Casomax is not indicated for use in pregnant women. There is no information available on the presence of Casomax in human milk, or on the effects on the breastfed infant or on milk production. Casomax has been detected in rat milk.

Where can I get more information (Casodex)?

Your pharmacist can provide more information about Casomax.

Why is this medication prescribed?

Casomax is used with another medication (gonadotropin-releasing hormone (GnRH) agonists; such as leuprolide or goserelin) to treat metastatic prostate cancer (cancer that started in the prostate and has spread to other parts of the body). Casomax is in a class of medications called nonsteroidal antiandrogens. It works by blocking the effect of androgen (a male hormone), to stop the growth and spread of cancer cells.

Clinical Trials Accepting Patients

Find Clinical Trials for Casomax - Check for trials from NCI's list of cancer clinical trials now accepting patients.

Important: The drug information on this page is meant to be educational. It is not a substitute for medical advice. The information may not cover all possible uses, actions, interactions, or side effects of this drug, or precautions to be taken while using it. Please see your health care professional for more information about your specific medical condition and the use of this drug.


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