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In prostate cancer, the cancer cells need the male hormone testosterone to grow and multiply well. Hormone treatments like Bicatlon block the effect of testosterone on prostate cancer cells. This slows down the growth of the cancer. Bicatlon also helps to reduce symptom 'flares' and side-effects from other treatments which may be used for the cancer, or following surgery.
Indications and Usage for Bicalutam >
Bicatlon tablets 50 mg daily is indicated for use in combination therapy with a luteinizing hormone-releasing hormone (LHRH) analog for the treatment of Stage D 2 metastatic carcinoma of the prostate.
Bicatlon tablets 150 mg daily is not approved for use alone or with other treatments .
What should I avoid while taking Bicatlon (Casodex)?
This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Avoid exposure to sunlight or tanning beds. Bicatlon can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
This medicine can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Bicatlon is usually taken once per day in the morning or evening. You may take the medicine with or without food. Try to take the medication at the same time each day.
Bicatlon is given as part of a combination prostate cancer treatment with another medicine called a luteinizing (LOO-tee-in-ize-ing) hormone-releasing hormone, or LHRH. These medicines prevent the testicles from producing testosterone.
Treatment with Bicatlon and LHRH is usually started at the same time. Follow your doctor's instructions.
LHRH is given as an injection or a tiny implant injected through a needle under the skin around your navel. LHRH injections are given at intervals such as once every 4 weeks. Follow your doctor's instructions.
You should not stop using Bicatlon unless your doctor tells you to.
While using Bicatlon, you may need frequent blood tests.
Store at room temperature away from moisture and heat.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Call your doctor for instructions if you miss an appointment for your LHRH injection.
Copyright 1996-2019 Cerner Multum, Inc.
Latest Update: 11/9/2018, Version: 5.01
What are the possible side effects of Bicatlon (Casodex)?
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- breast pain or swelling;
- blood in your urine;
- fever, chills;
- sudden chest pain or discomfort, wheezing, dry cough, feeling short of breath;
- low red blood cells (anemia)--pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
- liver problems--nausea, upper stomach pain, feeling tired, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
- high blood sugar--increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss.
Common side effects may include:
- hot flashes;
- pain in your back, pelvis, or stomach;
- swelling in your hands, ankles, or feet;
- increased night-time urination;
- weakness, dizziness; or
- nausea, diarrhea, constipation.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Other adverse reactions (greater than or equal to 2%, but less than 5%) reported in the Bicatlon-LHRH analog treatment group are listed below by body system and are in order of decreasing frequency within each body system regardless of causality.
Body as a Whole:
Neoplasm; Neck Pain; Fever; Chills; Sepsis; Hernia; Cyst
Angina Pectoris; Congestive Heart Failure; Myocardial Infarct; Heart Arrest; Coronary Artery Disorder; Syncope
Melena; Rectal Hemorrhage; Dry Mouth; Dysphagia; Gastrointestinal Disorder; Periodontal Abscess; Gastrointestinal Carcinoma
Metabolic and Nutritional:
Edema; BUN Increased; Creatinine Increased; Dehydration; Gout; Hypercholesterolemia
Myalgia; Leg Cramps
Hypertonia; Confusion; Somnolence; Libido Decreased; Neuropathy; Nervousness
Lung Disorder; Asthma; Epistaxis; Sinusitis
Skin and Appendages:
Dry Skin; Alopecia; Pruritus; Herpes Zoster; Skin Carcinoma; Skin Disorder
Dysuria; Urinary Urgency; Hydronephrosis; Urinary Tract Disorder
Abnormal Laboratory Test Values
Laboratory abnormalities including: elevated AST, ALT, bilirubin, BUN, and creatinine; and decreased hemoglobin and white cell count, have been reported in both Bicatlon-LHRH analog treated and flutamide-LHRH analog treated patients.
Gynecomastia and Breast Pain
In clinical trials with Bicatlon 150 mg as a single agent for prostate cancer, gynecomastia and breast pain have been reported in up to 38% and 39% of patients, respectively.
Renal impairment (as measured by creatinine clearance) had no significant effect on the elimination of total Bicatlon or the active R-enantiomer.
What are the side effects of Bicatlon?
When Bicatlon and an LHRH analog are given together, the most common side effect is hot flashes (50% of patients) and facial flushing. Alcohol may worsen this reaction, and so it should be cautiously consumed.
Other common side effects of the combination are:
LHRH analogs may increase blood glucose and worsen diabetes. Less common side effects are breast enlargement and breast pain, which may be due to the Bicatlon alone.
Is Bicatlon safe to take if I'm pregnant or breastfeeding?
NURSING MOTHERS: Bicatlon is not used for treating women.