Basteen tablets

Basteen

  • Active Ingredient: Norfloxacin
  • 400 mg
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What is Basteen?

The active ingredient of Basteen brand is norfloxacin. The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content.

Used for

Basteen is used to treat diseases such as: Bladder Infection, Campylobacter Gastroenteritis, Epididymitis, Non-Specific, Gonococcal Infection, Uncomplicated, Kidney Infections, Prostatitis, Salmonella Enteric Fever, Salmonella Gastroenteritis, Shigellosis, Traveler's Diarrhea, Urinary Tract Infection.

Side Effect

Possible side effects of Basteen include: vomiting; muscle weakness; pain or burning while urinating; irritability; blistering, peeling, or loosening of the skin.

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DRUG INTERACTIONS

Quinolones, including NOROXIN, have been shown in vitro to inhibit CYP1A2. Concomitant use with drugs metabolized by CYP1A2 (e.g., caffeine, clozapine, ropinirole, tacrine, theophylline, tizanidine) may result in increased substrate drug concentrations when given in usual doses. Patients taking any of these drugs concomitantly with Basteen should be carefully monitored.

Elevated plasma levels of theophylline have been reported with concomitant quinolone use. There have been reports of theophylline-related side effects in patients on concomitant therapy with Basteen and theophylline. Therefore, monitoring of theophylline plasma levels should be considered and dosage of theophylline adjusted as required.

Elevated serum levels of cyclosporine have been reported with concomitant use of cyclosporine with NOROXIN. Therefore, cyclosporine serum levels should be monitored and appropriate cyclosporine dosage adjustments made when these drugs are used concomitantly.

Quinolones, including NOROXIN, may enhance the effects of oral anticoagulants, including warfarin or its derivatives or similar agents. When these products are administered concomitantly, prothrombin time or other suitable coagulation tests should be closely monitored.

The concomitant administration of quinolones including NOROXIN with glyburide (a sulfonylurea agent) has, on rare occasions, resulted in severe hypoglycemia. Therefore, monitoring of blood glucose is recommended when these agents are co-administered.

Diminished urinary excretion of NOROXIN has been reported during the concomitant administration of probenecid and NOROXIN.

The concomitant use of nitrofurantoin is not recommended since nitrofurantoin may antagonize the antibacterial effect of NOROXIN in the urinary tract.

Multivitamins, or other products containing iron or zinc, antacids or sucralfate, should not be administered concomitantly with, or within 2 hours of, the administration of NOROXIN, because they may interfere with absorption resulting in lower serum and urine levels of NOROXIN.

Videx® (Didanosine) chewable/buffered tablets or the pediatric powder for oral solution should not be administered concomitantly with, or within 2 hours of, the administration of NOROXIN, because these products may interfere with absorption resulting in lower serum and urine levels of NOROXIN.

Some quinolones have also been shown to interfere with the metabolism of caffeine. This may lead to reduced clearance of caffeine and a prolongation of the plasma half-life that may lead to accumulation of caffeine in plasma when products containing caffeine are consumed while taking NOROXIN.

The concomitant administration of a non-steroidal anti-inflammatory drug (NSAID) with a quinolone, including NOROXIN, may increase the risk of CNS stimulation and convulsive seizures. Therefore, NOROXIN should be used with caution in individuals receiving NSAIDS concomitantly.

Fluoroquinolone Antibiotics

The fluoroquinolone antibiotics (e.g., Basteen , ofloxacin, levofloxacin, and ciprofloxacin) are active against the majority of bacteria commonly implicated in traveler's diarrhea in many parts of the world. Although the fluoroquinolones are generally accepted as one of the antibiotics of choice for empiric treatment of traveler's diarrhea in adults, growing resistance to this class of antibiotics among Campylobacter spp. in some Southeast Asian countries poses a significant challenge to its usefulness for empiric treatment of traveler's diarrhea. In Thailand, for instance, the rate of fluoroquinolone resistance of Campylobacter jejuni is extremely high.

Basteen Dosage

Basteen is usually taken every 12 hours. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take this medicine with a full glass of water (8 ounces). Drink several extra glasses of fluid each day while you are taking Basteen.

Take Basteen on an empty stomach 1 hour before or 2 hours after eating a meal, drinking milk, or eating a dairy product such as yogurt.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Basteen will not treat a viral infection such as the common cold or flu.

If you are being treated for gonorrhea, your doctor may also have you tested for syphilis, another sexually transmitted disease.

Do not share this medication with another person (especially a child), even if they have the same symptoms you have.

Store at room temperature away from moisture and heat.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What are some other side effects of Basteen?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Headache.
  • Dizziness.
  • Upset stomach or throwing up.
  • Diarrhea.
  • Constipation.
  • Not hungry.
  • Feeling sleepy.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

Can Basteen cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with Basteen. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Peripheral Neuropathy

Fluoroquinolones, including NOROXIN, have been associated with an increased risk of peripheral neuropathy. Cases of sensory or sensorimotor axonal polyneuropathy affecting small and/or large axons resulting in paresthesias, hypoesthesias, dysesthesias and weakness have been reported in patients receiving fluoroquinolones, including NOROXIN. Symptoms may occur soon after initiation of Basteen and may be irreversible in some patients (see WARNINGS). Discontinue NOROXIN immediately if the patient experiences symptoms of peripheral neuropathy including pain, burning, tingling, numbness, and/or weakness, or other alterations in sensations including light touch, pain, temperature, position sense and vibratory sensation, and/or motor strength in order to minimize the development of an irreversible condition. Avoid fluoroquinolones, including NOROXIN, in patients who have previously experienced peripheral neuropathy (see ADVERSE REACTIONS).

Antibiotic Regimens

Basteen , a poorly absorbed fluoroquinolone, has been used to achieve selective intestinal decontamination in cirrhotic patients; Basteen has several characteristics that make it suitable for prophylaxis: ▪

Poor absorption when taken orally

Effectiveness against enteric gram-negative organisms

Sparing of gram-positive and anaerobic organisms to maintain their protective role in the normal gut flora

Basteen reduces the incidence of SBP, delays progression to hepatorenal syndrome, and improves overall survival (see Table 11.8 ).

In patients who have survived an episode of SBP: ▪

Recurrence can be as high as 68% at 1 year without antibiotic prophylaxis.

Basteen, 400 mg orally daily, has been shown to decrease the probability of recurrent SBP to 20% at 1 year.

Basteen prophylaxis is cost effective in reducing recurrent SBP.

However, Basteen treatment does not alter the overall mortality in these patients.

In patients with cirrhosis and gastrointestinal hemorrhage: ▪

The incidence of SBP can be as high as 45% to 66% at 1 year without antibiotic prophylaxis.

Antibiotic prophylaxis started immediately and continued for 7 days decreases the incidence of SBP to 10% to 20%.

Antibiotic prophylaxis may improve survival in these patients.

Intravenous ceftriaxone has been shown to be more effective than oral Basteen for SBP prophylaxis in patients with advanced cirrhosis and gastrointestinal hemorrhage.

In hospitalized patients with ascitic flu > ▪

The overall probability of new-onset SBP is 20% in 1 year.

Prophylaxis with Basteen 400 mg orally daily decreases in-hospital incidence of SBP from 22% to 0% without an effect on in-hospital mortality.

Trimethoprim–sulfamethoxazole, one double-strength tablet orally daily, has also been reported to be effective in preventing SBP.

How should I take Basteen?

Basteen is usually taken every 12 hours. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take this medicine with a full glass of water (8 ounces). Drink several extra glasses of fluid each day while you are taking Basteen.

Take Basteen on an empty stomach 1 hour before or 2 hours after eating a meal, drinking milk, or eating a dairy product such as yogurt.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Basteen will not treat a viral infection such as the common cold or flu.

If you are being treated for gonorrhea, your doctor may also have you tested for syphilis, another sexually transmitted disease.

Do not share this medication with another person (especially a child), even if they have the same symptoms you have.

Store at room temperature away from moisture and heat.

Antimicrobial spectrum

Basteen is active against many gram-positive bacteria and gram-negative bacteria. Relatively long post-antibiotic effect. Basteen is less potent than ciprofloxacin and is not used to treat systemic infections.


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