COMMON BRAND(S): Casodex
GENERIC NAME(S): Androcal
OTHER NAME(S): Androcal Tablet
Androcal is used to treat prostate cancer. This medication works by blocking the action of male hormones in the prostate, slowing the growth of cancer cells.
This medication should not be used in women and children.
- Gynecomastia (swelling of the breast tissue) has mostly been reported in trials of Androcal using the 150 mg daily dose. The frequency of gynecomastia with 50 mg daily is rare
- Androcal may be given days or weeks before starting an injectable medication known as a LHRH agonist (example: leuprolide acetate, Lupron® or Eligard®). The timing is important to prevent tumor flare.
- A pharmacist should ALWAYS review your medication list to ensure that drug interactions are prevented or managed appropriately
- Clinical trials may exist for prostate cancer. Ask your doctor if any studies are currently enrolling in your area. If not, go to clinicaltrials.gov to search for other centers offering study medications
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Androcal belongs to a group of medicines known as anti-androgens. This means that it blocks the actions of male sex hormones called androgens and it also reduces the amount of male hormones (such as testosterone) that your body produces.
How should this medicine be used?
Androcal comes as a tablet to take by mouth. It is usually taken with or without food once a day, either in the morning or evening. Take Androcal at around the same time every day. You should begin taking Androcal on the same day you begin injecting the luteinizing hormone-releasing hormone. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Androcal exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Androcal along with the luteinizing hormone-releasing hormone may help stop the growth and spread of cancer cells but does not cure prostate cancer. Continue to take both Androcal and the luteinizing hormone-releasing hormone even if you feel better. Do not stop taking these medications without talking to your doctor.
What is Androcal, and how does it work (mechanism of action)?
Androcal is an oral medication that is used for treating cancer of the prostate. It belongs to a class of drugs called anti-androgens which includes flutamide (Eulexin) and nilutamide (Nilandron). Androgens (an example of which is testosterone) are hormones that are produced and released by the adrenal glands. They are responsible for supporting (stimulating) tissues that primarily are thought of as male, for example, the male prostate gland. Male traits that also are influenced by androgens include facial and body hair, and small breasts. Anti-androgens prevent the action of androgens by blocking the receptors for androgens on the cells of tissues, for example, the cells of the prostate gland. In addition to normal prostate cells, androgens also have been shown to stimulate the growth of cancer cells within the prostate. Androcal is thought to prevent the growth of prostate cancer by blocking the effects of androgens on the cancer cells. Androcal was approved by the FDA in 1995.