Alfusin tablets

Alfusin

  • Active Ingredient: Alfuzosin
  • 10 mg
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What is Alfusin?

The active ingredient of Alfusin brand is alfuzosin. Alfuzosin is an alpha-adrenergic (AL-fa ad-ren-ER-jik) blocker. Alfuzosin helps relax the muscles in the prostate and bladder neck, making it easier to urinate.

Used for

Alfusin is used to treat diseases such as: Benign Prostatic Hyperplasia.

Side Effect

Possible side effects of Alfusin include: stuffy or runny nose; inability to have or keep an erection; fainting; loss of voice; fever; chest tightness or heaviness.

How to Buy Alfusin tablets online?

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Where can I get more information (Uroxatral)?

Your pharmacist can provide more information about Alfusin.

DESCRIPTION

Each UROXATRAL extended-release tablet contains 10 mg Alfusin hydrochloride as the active ingredient. Alfusin hydrochloride is a white to off-white crystalline powder that melts at approximately 240°C. It is freely soluble in water, sparingly soluble in alcohol, and practically insoluble in dichloromethane.

Alfusin hydrochloride is (R,S)-N- propyl] tetrahydro-2-furancarboxamide hydrochloride. The empirical formula of Alfusin hydrochloride is C19H27N5O4•HCl. The molecular weight of Alfusin hydrochloride is 425.9. Its structural formula is:

The tablet also contains the following inactive ingredients: colloidal silicon dioxide (NF), ethylcellulose (NF), hydrogenated castor oil (NF), hydroxypropyl methylcellulose (USP), magnesium stearate (NF), mannitol (USP), microcrystalline cellulose (NF), povidone (USP), and yellow ferric oxide (NF).

CONTRAINDICATIONS

UROXATRAL is contraindicated for use:

  • in patients with moderate or severe hepatic impairment (Childs-Pugh categories B and C), since Alfusin blood levels are increased in these patients .
  • with potent CYP3A4 inhibitors such as ketoconazole, itraconazole, and ritonavir, since Alfusin blood levels are increased .
  • in patients with known hypersensitivity, such as urticaria and angioedema, to Alfusin hydrochloride or any component of UROXATRAL tablets

Can Alfusin cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with Alfusin. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

BPH and blood pressure drugs

Avoid using Alfusin with other alpha-blockers. Combining the drugs may increase your risk of side effects since the medications work similarly. Examples of other alpha-blockers include:

  • doxazosin
  • prazosin
  • silodosin
  • tamsulosin
  • terazosin

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • rash
  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
  • hoarseness
  • difficulty swallowing or breathing
  • chest pain
  • fainting

Alfusin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Important Information

You should not take Alfusin if you have moderate to severe liver disease.

Many drugs can affect Alfusin, and some should not be used at the same time. Tell your doctor about all your current medicines and any you start or stop using.

Alfusin lowers blood pressure and may cause dizziness or fainting, especially if you take heart or blood pressure medications. Avoid driving or hazardous activity until you know how Alfusin will affect you.

Call your doctor at once if you have a light-headed feeling, like you might pass out.

Drugs that inhibit CYP3A4 enzyme

The CYP3A4 enzyme processes Alfusin in your liver. Medications that block this liver enzyme may cause the levels of Alfusin to increase in your body. This may put you at risk for more side effects. Alfusin shouldn’t be used with strong inhibitors of this enzyme.

A few examples of these drugs include:

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

This drug comes with several warnings.

Is Alfusin safe to take if I'm pregnant or breastfeeding?

  • Alfusin is not used by women; however, studies in animals have shown no evidence of fetal toxicity, even with exceedingly high doses of Alfusin.
  • Alfusin is not prescribed for women.

Alfusin Interactions

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Drinking alcohol with this medicine can cause side effects.

Tell your doctor about all your current medicines. Many drugs can increase your risk of very low blood pressure while taking Alfusin, especially:

  • heart or blood pressure medication;
  • nitrate medication (such as nitroglycerin); or
  • sildenafil (Viagra) and other erectile dysfunction medicines.

This list is not complete. Many other drugs can affect Alfusin, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

What should I discuss with my healthcare provider before taking Alfusin (Uroxatral)?

You should not take Alfusin if you are allergic to it, or if you have:

Some medicines can cause unwanted or dangerous effects when used with Alfusin. Your doctor may change your treatment plan if you also use:

  • an antibiotic;
  • antifungal medicine;
  • heart medication;
  • antiviral medicine to treat hepatitis C or HIV/AIDS; or
  • medicines similar to Alfusin (doxazosin, prazosin, silodosin, tamsulosin, or terazosin).

Tell your doctor if you have ever had:

  • low blood pressure, especially if caused by taking medications;
  • liver disease;
  • kidney disease;
  • prostate cancer; or
  • long QT syndrome (in you or a family member).

Alfusin can affect your pupils. If you have cataract surgery, tell your surgeon ahead of time that you use this medicine.

Alfusin is not for use in women, and the effects of this medicine during pregnancy or in breastfeeding women are unknown.

Alfusin is not approved for use by anyone younger than 18 years old.

Alfusin side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

a light-headed feeling, like you might pass out;

new or worsening chest pain;

upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

penis erection that is painful or lasts 4 hours or longer.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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