Zolvera tablets

Zolvera

  • Active Ingredient: Verapamil
  • 240 mg, 120 mg, 80 mg
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What is Zolvera?

The active ingredient of Zolvera brand is verapamil. Verapamil is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels. Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy α-(1-methylethyl) hydrochloride Verapamil hydrochloride, USP is an almost white, crystalline powder, practically free of odor, with a bitter taste. It is soluble in water, chloroform, and methanol. Verapamil hydrochloride is not chemically related to other cardioactive drugs. Inactive ingredients include calcium sulfate, colloidal silicon dioxide, croscarmellose sodium, hydroxypropyl cellulose, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, pregelatinized starch (corn), sodium lauryl sulfate, talc and titanium dioxide.

Used for

Zolvera is used to treat diseases such as: Angina, Arrhythmia, Bipolar Disorder, Cluster Headaches, High Blood Pressure, Idiopathic Hypertrophic Subaortic Stenosis, Migraine Prevention, Nocturnal Leg Cramps, Supraventricular Tachycardia.

Side Effect

Possible side effects of Zolvera include: Acid or sour stomach; lightheadedness, dizziness, or fainting; muscle aching or cramping; coughing that sometimes produces a pink frothy sputum; difficulty in moving; unusual tiredness or weakness; nausea; stomach discomfort, upset, or pain.

How to Buy Zolvera tablets online?

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Examples of Zolvera in a Sentence

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'Zolvera.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

Abstract

Tumor side population (SP) cells display stem-like properties that can be modulated by treatment with the calcium channel blocker Zolvera. Zolvera can enhance the cytotoxic effects of chemotherapeutic drugs and multi-drug resistance by targeting the transport function of the P-glycoprotein (P-gp). This study focused on the therapeutic potential of Zolvera on stem-like SP tumor cells, and further investigated its chemosensitizing effects using L3.6pl and AsPC-1 pancreatic carcinoma models. As compared to parental L3.6pl cells (0.9±0.22%), L3.6pl gemcitabine-resistant cells (L3.6plGres) showed a significantly higher percentage of SP cells (5.38±0.99%) as detected by Hoechst 33342/FACS assays. The L3.6plGres SP cells showed stable gemcitabine resistance, enhanced colony formation ability and increased tumorigenicity. Zolvera effectively inhibited L3.6plGres and AsPC-1 SP cell proliferation in vitro. A pro-apoptotic effect of Zolvera was observed in L3.6pl cells, but not in L3.6plGres cells, which was linked to their differential expression of P-gp and equilibrative nucleoside transporter-1 (ENT-1). In an orthotopic pancreatic cancer mouse model, both low and high dose Zolvera was shown to substantially reduce L3.6plGres-SP cell tumor growth and metastasis, enhance tumor apoptosis, and reduce microvascular density.

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Why is this medication prescribed?

Zolvera is used to treat high blood pressure and to control angina (chest pain). The immediate-release tablets are also used alone or with other medications to prevent and treat irregular heartbeats. Zolvera is in a class of medications called calcium-channel blockers. It works by relaxing the blood vessels so the heart does not have to pump as hard. It also increases the supply of blood and oxygen to the heart and slows electrical activity in the heart to control the heart rate.

High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

DESCRIPTION

COVERA-HS (Zolvera hydrochloride) is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist). COVERA-HS is available for oral administration as pale yellow, round, film-coated tablets containing 240 mg of Zolvera hydrochloride and as lavender, round, film-coated tablets containing 180 mg of Zolvera hydrochloride. Zolvera is administered as a racemic mixture of the R and S enantiomers. The structural formulae of the Zolvera HCl enantiomers are:

Zolvera HCl is an almost white, crystalline powder, practically free of odor, with a bitter taste. It is soluble in water, chloroform, and methanol. Zolvera HCl is not chemically related to other cardioactive drugs.

Inactive ingredients are black ferric oxide, BHT, cellulose acetate, hydroxyethyl cellulose, hydroxypropyl cellulose, hypromellose, magnesium stearate, polyethylene glycol, polyethylene oxide, polysorbate 80, povidone, sodium chloride, titanium dioxide, and coloring agents: 240 mg—FD&C Blue No. 2 Lake and D&C Yellow No. 10 Lake; 180 mg—FD&C Blue No. 2 Lake and D&C Red No. 30 Lake.

OVERDOSE

Treat all Zolvera overdoses as serious and maintain observation for at least 48 hours (especially sustained-release Zolvera products), preferably under continuous hospital care. Delayed pharmacodynamic consequences may occur with the sustained-release formulations. Zolvera is known to decrease gastrointestinal transit time.

Treatment of overdosage should be supportive. Beta-adrenergic stimulation or parenteral administration of calcium solutions may increase calcium ion flux across the slow channel and have been used effectively in treatment of deliberate overdosage with Zolvera. In a few reported cases, overdose with calcium channel blockers has been associated with hypotension and bradycardia, initially refractory to atropine but becoming more responsive to this treatment when the patients received large doses (close to 1 gram/hour for more than 24 hours) of calcium chloride. Zolvera cannot be removed by hemodialysis. Clinically significant hypotensive reactions or high degree AV block should be treated with vasopressor agents or cardiac pacing, respectively. Asystole should be handled by the usual measures including cardiopulmonary resuscitation.

Pregnancy and Zolvera

The safety of Zolvera during pregnancy and while breastfeeding has not been determined.

Q: Can Zolvera and/or tramadol impair driving?

A: Tramadol is in a drug class called opiate agonists. Tramadol is used for the management of moderate to moderately severe pain. Tramadol works by altering pain sensation in the body. The most common side effects with tramadol are: dizziness/vertigo; nausea; constipation; headache; sleepiness; vomiting; itching; central nervous system stimulation (i.e., nervousness, anxiety, agitation, continuous muscle contraction, euphoria, emotional instability, and hallucinations); lack or loss of strength and energy; sweating; upset stomach; dry mouth and diarrhea. According to tramadol prescribing information, tramadol may impair the mental or physical abilities required to perform potentially hazardous tasks, like driving a motor vehicle or operating machinery. Caution should be used accordingly. Zolvera is in a drug class called calcium channel blockers. Zolvera is used to lower high blood pressure. Zolvera is also used to manage angina (chest pain). In addition, the immediate release version of Zolvera is used alone or combined with other medications to prevent or treat conditions that cause abnormal heartbeats. Zolvera works by relaxing blood vessels. This allows the heart to not have to pump as hard. Zolvera also allows for a greater supply of blood and oxygen to the heart. Zolvera controls heart rate by slowing electrical activity in the heart. The most common side effects with Zolvera are: constipation; dizziness; nausea; low blood pressure; headache; swelling of tissues due to accumulation of fluid; congestive heart failure/fluid in the lungs; fatigue; difficulty breathing; slow heart beat; and impairment of electrical impulses in the heart. Other side effects with Zolvera include confusion; balance disorders; shakiness; sleepiness; and blurred vision. Prescribing information for Zolvera does not carry the same warning as tramadol about impairment of mental or physical abilities required to perform potentially hazardous tasks. However, people who experience certain side effects with Zolvera (e.g., dizziness, confusion; balance disorders; shakiness; sleepiness; and blurred vision) may have an impaired ability to drive a motor vehicle or operate machinery. Derek Dore, PharmD

By Julie Marks | Medically Reviewed by Ruthan White, PharmD

Latest Update: 2014-10-28 Copyright © 2014 Everyday Health Media, LLC

Geriatric Use

The pharmacokinetics of COVERA-HS were studied after 5 consecutive nights of dosing 180 mg in 30 healthy young (19–43 years) versus 30 healthy elderly (65–80 years) male and female subjects. Older subjects had significantly higher mean Zolvera Cmax, Cmin, and AUC(0–24h) compared to younger subjects. Older subjects had mean AUCs that were approximately 1.7–2.0 times higher than those of younger subjects as well as a longer average Zolvera t½ (approximately 20 hr vs. 13 hr). These results were typical of the age-related differences seen with many drug products in clinical medicine. Lean body mass was inversely related to AUC, but no gender difference was observed in the clinical trials of COVERA-HS. However, there are conflicting data in the literature suggesting that Zolvera clearance may decrease with age in women to a greater degree than in men. Mean Tmax was similar in young and elderly subjects.

Before taking this medicine

You should not use Zolvera if you are allergic to it, or if you have a serious heart condition such as:

"sick sinus syndrome" or "AV block" (unless you have a pacemaker);

severe heart failure;

slow heartbeats that have caused you to faint; or

certain heart rhythm disorders (Wolff-Parkinson-White, Lown-Ganong-Levine syndrome).

To make sure Zolvera is safe for you, tell your doctor if you have:

congestive heart failure;

It is not known whether Zolvera will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breast-feed while using this medicine.

Other things to know about Zolvera

Before starting treatment with Zolvera, patients should talk to their doctor about all their medical conditions. Some people should not take Zolvera, including those with severe heart abnormalities, low blood pressure, poor heart function, certain heart rhythm problems, certain types of blockages in the heart called second or third degree atrioventricular (AV) block, rapid heart rate or any allergic reaction to Zolvera.

Patients should talk to their doctor about all their medications (prescription and over-the-counter), supplements, and herbal remedies they are taking. Some medications should not be taken with Zolvera, including CYP3A4 inhibitors. Other medications taken in combination with Zolvera may require close monitoring by a doctor, including simvastatin, lovastatin, beta blockers, and digoxin.

Grapefruit juice can significantly increase the levels of Zolvera in the body.

Drinking alcohol while taking Zolvera can increase the blood alcohol concentrations and prolong the effect of alcohol in the body.


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