What Are Side Effects Associated with Using Xadem?
Common side effects of Xadem include:
This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.
Steady-state trough concentrations of Xadem sulfoxide were about 56% higher when 8 mg dexamethasone was co-administered with each dose of Xadem (15 mg/kg/day) in 8 neurocysticercosis patients.
What are the uses of Xadem 400 MG Tablet
The medication is utilised to fix the accompanying ailments
Alopecia universalis was seen in a 70-year-old male on day 20 of daily treatment with Xadem 15 mg/kg/day for Echinococcus. Alopecia fully recovered 1 month after stopping the medication .
Another case of alopecia in the form of telogen effluvium was reported in a 27-year-old female patient in her second week of a 2-week course of daily Xadem 400 mg for treatment of cutaneous larva migrans. Remission was noted in 3 months will full restoration of normal hair observed at 11 months .
A novel case of psychosis in a 36-year-old female was documented after receiving a single dose of Xadem 400 mg and ivermectin 12 mg for suspected helminthic infection. Symptoms of persecutory delusions and auditory hallucinations improved within 48 h and resolved within 1 week. Xadem was the suspected cause given its ability to cross the blood–brain barrier .
Liver: A single case of toxic hepatitis was noted in Turkey after using Xadem 800 mg/day for treatment of hydatid cysts .
Neurologic: Starting 3 days after treatment with Xadem for presumed intestinal helminths, a patient experienced seizures (focal, myoclonic, generalised and status epilepticus) headache and contralateral hypoesthesia and ultimately expired. Postmortem analysis revealed neurocysticercosis, highlighting the importance of judicious use of the drug in populations living in areas with high rates of coinfection with Taenia solium .
Xadem has been proven to be efficacious for gnathostomiasis, with cure rates of over 90% at a dose of 400 mg bd for 21 days. Small studies of ivermectin 200 µg/kg either as a stat dose or on two consecutive days seem to show similar efficacy to Xadem. Initial treatment is not always successful and second courses of treatment have been needed in some cases. Either Xadem or ivermectin may be used sequentially in such patients. Further trials are needed to determine whether relapse rates are lower with combination drugs than with monotherapy. Follow-up should be for at least 1 year. 19,20
Studies in children younger than 6 years are limited, but several studies have shown Xadem to be safe in children as young as 1 year of age. For children 1–2 years old, a dose of 200 mg is recommended. Use of Xadem in children
Hookworm infection is treated with Xadem, mebendazole, or pyrantel pamoate. Dosage is the same for children as for adults. Xadem should be taken with food. Xadem is not FDA-approved for treating hookworm infection.
Oral Xadem is available for human use in the United States.
Oral mebendazole is available for human use in the United States.
Pyrantel pamoate is available for human use in the United States.
What are the uses for Xadem?
Xadem is FDA approved for the treatment of the following parasitic infections:
- Hydatid Disease Xadem is used for the treatment of cystic hydatid disease of the liver, lung, and peritoneum, caused by dog tapeworm (Echinococcus granulosus) larvae.
- Neurocysticercosis Xadem is used to treat parenchymal neurocysticercosis due to active lesion caused by pork tapeworm (Taenia solium) larvae.
- Off-label use Xadem is also effective in treating infections caused by other parasites including Taenia saginata (beef tapeworm), Trichinella spiralis (pork worm), Trichuris trichiura (whipworm), Enterobius vermicularis (pinworm), Strongyloides stercoralis (threadworm), Ascaris lumbricoides (roundworm), Ancylostoma duodenale (hookworm), and Necator americanus (hookworm).