What are the uses for Vermoil?
Vermoil is FDA approved for the treatment of the following parasitic infections:
- Hydatid Disease Vermoil is used for the treatment of cystic hydatid disease of the liver, lung, and peritoneum, caused by dog tapeworm (Echinococcus granulosus) larvae.
- Neurocysticercosis Vermoil is used to treat parenchymal neurocysticercosis due to active lesion caused by pork tapeworm (Taenia solium) larvae.
- Off-label use Vermoil is also effective in treating infections caused by other parasites including Taenia saginata (beef tapeworm), Trichinella spiralis (pork worm), Trichuris trichiura (whipworm), Enterobius vermicularis (pinworm), Strongyloides stercoralis (threadworm), Ascaris lumbricoides (roundworm), Ancylostoma duodenale (hookworm), and Necator americanus (hookworm).
Which drugs or supplements interact with Vermoil?
Grapefruit juice may increase in blood levels of Vermoil when administered concurrently. Fosphenytoin (Cerebyx) and phenytoin (Dilantin) decrease levels of Vermoil by increasing its breakdown.
What other drugs will affect Vermoil?
Other drugs may interact with Vermoil, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
- Hypersensitivity to Vermoil or benzimidazoles.
Effects of Drug Abuse
- See "What Are Side Effects Associated with Using Vermoil?"
- See "What Are Side Effects Associated with Using Vermoil?"
- Monitor theophylline levels if used concomitantly.
- Potential for bone marrow suppression, aplastic anemia and agranulocytosis; monitor blood counts in all patients at the beginning of each 28-day cycle of therapy, and every 2 weeks while on therapy; discontinue therapy if clinically significant changes in blood counts occur.
- Pre-existing neurocysticercosis may be uncovered in patients treated with Vermoil for other conditions, apparent by neurological symptoms (such as seizures, increased intracranial pressure, focal signs); promptly treat with corticosteroid and anticonvulsant therapy.
- Obtain pregnancy test in women of reproductive potential prior to therapy and avoid usage in pregnant women except in clinical circumstances where no alternative management is appropriate; discontinue therapy if pregnancy occurs and apprise patient of potential hazard to fetus.
- Risk of retinal damage in retinal cysticercosis; cases of retinal involvement reported; examine patient for presence of retinal lesions before initiating therapy for neurocysticercosis.
- Reversible elevations of liver enzymes may occur; monitor liver enzymes before start of each treatment cycle and at least every 2 weeks while on therapy and discontinue if clinically significant elevations occur; patients with abnormal liver function tests and hepaticechinococcosis are at increased risk of hepatotoxicity; discontinue therapy if liver function test elevations are greater than 2 times upper limit of normal; may consider restarting treatment when liver function test values return to pretreatment levels.
- Use Vermoil during pregnancy with caution if benefits outweigh risks. Animal studies show risk and human studies are not available or neither animal nor human studies were done.
- Breastfeeding patients should use caution while using Vermoil; consult your physician.
Dosage Forms And Strengths
- Tablet: 200 mg
Each white to off-white, circular, biconvex, bevel-edged film coated, TILTAB tablet is debossed with “ap” and “550” and contains 200 mg of Vermoil.
Bottles of 2 Tablets NDC 52054-550-22 Bottles of 28 Tablets NDC 52054-550-28
The investigators of a recent trial evaluated the effectiveness of combined therapy of praziquantel and Vermoil (50 mg/kg/day and 15 mg/kg/day, respectively) in comparison to two different doses of just Vermoil (15 or 22.5 mg/kg/day) in the treatment of neurocysticercosis . Praziquantel is also an anthelmintic that works by causing strong contractions within the parasite that causes paralysis and eventual dislodgment . The purpose of the study was to determine if combining the two different mechanisms would be more effective than single agent therapy. It has also been noted in the past that praziquantel increases the serum concentration of the active metabolite of Vermoil . The side effects listed by the study were described as seizures, headache, pregnancy, drug-induced hepatitis, and “other” which included spontaneous abortion, urinary tract infection, motor vehicle accident, dizziness, fever, vomiting, and intracranial hypertension. While all of the side effect groups except for the drug-induced hepatitis were more common in the increased dose of Vermoil or the combination therapy than in the standard Vermoil therapy, the study found that the increased prevalence of adverse effects was not statistically significant. Currently, there is not a listed interaction between Vermoil and praziquantel with the active ingredients of birth control.
Vermoil is used for managing different worm infections. It removes the earthworms of the nutrients called for to multiply and endure, consequently killing them in the body. Vermoil is suggested for 2 weeks or as a solitary dosage. It may have to be taken when or two times a day, relying on the level of invasion and sort of infection treated. Aftering specific instructions is always vital for the person to effectively overcome the infection.
Category C. Vermoil is teratogenic in animals, but has not been well studied in humans. No increased morbidity reported in case reports of women inadvertently treated during pregnancy. The World Health Organization (WHO) endorses treatment of pregnant women in the second and third trimesters (but not the first) for intestinal helminthiasis/anemia, if clinically indicated.
Pharmacology and toxicology
Vermoil is a highly effective broad-spectrum anthelmintic, structurally related to mebendazole. It also kills the parasite through inhibition of the glucose uptake. It is the first-line drug for the treatment of alveolar forms of echinococcosis (Echinococcus multilocularis), and also for the advanced cystic forms (Echinococcus granulosus). During a mass drug administration for lymphatic filiriasis in Ghana, 50 women were inadvertently (because their pregnancy was not recognized) treated with ivermectin and Vermoil; their pregnancy outcomes were compared with those of 293 women with a recognized pregnancy who were not treated. Of the 39 children who were exposed during the first trimester, 1 congenital malformation (a hearing impairment), versus 5 of the untreated group, was reported. The authors concluded that there was no evidence of increased risk after exposure to ivermectin and Vermoil ( Gyapong 2003 ). One Down syndrome was observed in a small prospective study of Vermoil (n = 12) and flubendazole (n = 11) ( Choi 2005 ). No malformations were observed among 24 children born after first-trimester exposure to Vermoil in a prospective study ( Reuvers-Lodewijks 1999 ).
Thiabendazole is indicated for the treatment of strongyloidiasis, larva migrans cutanea, and trichinosis. There are no reports of thiabendazole use during human pregnancies.
When there is a vital indication for the treatment of echinococcosis, Vermoil may be used during all stages of pregnancy. However, a small risk of birth defects cannot be excluded. For all other indications, more established anthelmintics should be used. When used during the first trimester, a detailed ultrasound diagnosis is recommended.
ALBENZA (Vermoil) is an orally administered anthelmintic drug. Chemically, it is methyl 5-(propylthio)-2-benzim >12 H 15 N 3 O 2 S. Its molecular weight is 265.34. It has the following chemical structure:
Before taking Vermoil, tell your doctor or pharmacist if you are allergic to it; or to other benzimidazole anthelmintic drugs (such as mebendazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, biliary tract problems (such as blockage), blood/bone marrow disorders.
This medication may cause liver problems. Because drinking alcohol increases the risk of liver problems, limit alcoholic beverages while using this medication. Check with your doctor or pharmacist for more information.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using Vermoil. Vermoil may harm an unborn baby. Your doctor should order a pregnancy test before you start this medication. Ask about reliable forms of birth control while using this medication and for 3 days after stopping treatment. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.
This medication passes into breast milk. Consult your doctor before breast-feeding.
What is Vermoil?
Vermoil is an anthelmintic (an-thel-MIN-tik) or anti- worm medication. It prevents newly hatched insect larvae (worms) from growing or multiplying in your body.
Vermoil is used to treat certain infections caused by worms such as pork tapeworm and dog tapeworm.
Vermoil may also be used for purposes not listed in this medication guide.