Drug forms and strengths
- Form: oral tablet
- Strengths: 40 mg, 80 mg, 160 mg, 320 mg
- Form: oral tablet
- Strengths: 40 mg, 80 mg, 160 mg, 320 mg
Dosage for high blood pressure (hypertension)
Adult dosage (ages 17–64 years)
- Starting dosage: 80–160 mg taken once per day.
- Dosage range: 80–320 mg taken once per day.
Child dosage (ages 6–16 years)
- Starting dosage: 1.3 mg/kg of body weight taken by mouth once daily (up to 40 mg total per day).
- Dosage range: 1.3–2.7 mg/kg of body weight taken once daily (up to 40–160 mg total per day).
Child dosage (ages 0–5 years)
This drug shouldn’t be used in children younger than 6 years.
Senior dosage (ages 65 years and older)
There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A normal adult dosage may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dosage or a different treatment schedule.
Q: What is the diference between Valtan and a brand name such as Cosaar or Diovan?
A: Valtan is the generic name for Diovan. Cozaar (losartan) is the brand name for another drug very similar to Diovan. Both Diovan and Cozaar belong to the class of drugs called angiostension II receptor antagonists (ARBs). These drugs are used for blood pressure. Diovan and Cozaar keep blood vessels from narrowing which improves blood flow and lowers blood pressure. Both drugs have similar side effects such as headache, drowsiness, or cough. For information on Diovan or Cozaar visit Everyday Health at the link //www.everydayhealth.com/drugs/ Kimberly Hotz, PharmD.
Mechanism Of Action
Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Diovan (Valtan) blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin II synthesis.
There is also an AT2 receptor found in many tissues, but AT2 is not known to be associated with cardiovascular homeostasis. Valtan has much greater affinity (about 20,000-fold) for the AT1 receptor than for the AT2 receptor. The increased plasma levels of angiotensin II following AT1 receptor blockade with Valtan may stimulate the unblocked AT2 receptor. The primary metabolite of Valtan is essentially inactive with an affinity for the AT1 receptor about one-200th that of Valtan itself.
Blockade of the renin-angiotensin system with ACE inhibitors, which inhibit the biosynthesis of angiotensin II from angiotensin I, is widely used in the treatment of hypertension. ACE inhibitors also inhibit the degradation of bradykinin, a reaction also catalyzed by ACE. Because Valtan does not inhibit ACE (kininase II), it does not affect the response to bradykinin. Whether this difference has clinical relevance is not yet known. Valtan does not bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation.
Blockade of the angiotensin II receptor inhibits the negative regulatory feedback of angiotensin II on renin secretion, but the resulting increased plasma renin activity and angiotensin II circulating levels do not overcome the effect of Valtan on blood pressure.
Q: I take Diovan and it seems to make me gain weight. Is there another medication I can take that won't have that effect?
A: One of the possible side effects of any high blood pressure medication is weight gain. Diovan (Valtan) is in a class of antihypertensive medications called angiotensin II blockers and is relatively innocuous (safe with fewer side effects) compared to many of the other high blood pressure medications. However, you may consider asking your physician if you are a candidate for diuretics such as Lasix (furosemide) or HCTZ (hydrochlorothiazide). For more information please refer to these links: //www.everydayhealth.com/drugs/diovan and //www.everydayhealth.com/drugs/lasix
Take Valtan even if you feel well, as you will still be getting the benefits of the medicine.
1. About Valtan
Valtan is a medicine widely used to treat high blood pressure and heart failure. It's also sometimes prescribed after a heart attack.
Valtan is only available on prescription. It comes as tablets, capsules and as a liquid that you swallow.
Carcinogenesis, Mutagenesis, Impairment Of Fertility
There was no evidence of carcinogenicity when Valtan was administered in the diet to mice and rats for up to 2 years at doses up to 160 and 200 mg/kg/day, respectively. These doses in mice and rats are about 2.6 and 6 times, respectively, the maximum recommended human dose on a mg/m 2 basis. (Calculations assume an oral dose of 320 mg/day and a 60-kg patient.)
Mutagenicity assays did not reveal any Valtan-related effects at either the gene or chromosome level. These assays included bacterial mutagenicity tests with Salmonella (Ames) and E coli; a gene mutation test with Chinese hamster V79 cells; a cytogenetic test with Chinese hamster ovary cells; and a rat micronucleus test.
Valtan had no adverse effects on the reproductive performance of male or female rats at oral doses up to 200 mg/kg/day. This dose is 6 times the maximum recommended human dose on a mg/m basis. (Calculations assume an oral dose of 320 mg/day and a 60-kg patient.)
The sections below will provide you with more specific information and guidelines related to Valtan and its correct use. Please read them carefully.
In 2002, the US Food & Drug Administration approved a leading high blood pressure medicine Diovan® (Valtan) to treat heart failure in patients who are intolerant of angiotensin-converting-enzyme (ACE) inhibitors, a common type of heart failure therapy.
Valtan, an angiotensin II receptor blocker (ARB), is the top-prescribed ARB franchise in the U.S. and the first drug in its class to obtain an indication beyond hypertension.
The FDA expanded the drug’s heart failure labeling. Valtan can now be prescribed in a broader range of heart failure patients and is no longer limited to those intolerant of ACE inhibitors.
Why is this medication prescribed?
Valtan belongs to the class of medications known as angiotensin II inhibitors. It is used to treat high blood pressure. It is also used to treat heart failure and it can lower the need for hospitalization that happens from heart failure. Valtan can also treat left ventricular dysfunction after a heart attack. Left ventricular dysfunction occurs when the left ventricle (the main pumping chamber of the heart) stiffens and enlarges and can cause the lungs to fill with blood.
High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if the blood pressure is controlled.
Valtan works by blocking the action of a substance in the body that causes blood vessels to tighten. As a result, Valtan relaxes blood vessels which in turn lowers the blood pressure.
Other uses for this medicine
This drug may also be used to help protect the kidneys from damage due to diabetes.
However, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.
Dosage and using this medicine
The usual dose in patients with hypertension is 80 mg once daily, but doses of up to 320 mg daily have been used. In patients with congestive heart failure, twice daily dosing has been used.
The dose of Valtan will vary for each particular patients. Follow your doctor’s orders or the directions on the label.
Take Valtan with a full glass of water. Additionally, this medication can be taken with or without food.
What special precautions should I follow?
Do not use if you are pregnant. Stop using Valtan and tell your doctor right away if you become pregnant.
If you have diabetes, do not use Valtan together with any medication that contains aliskiren (a blood pressure medicine).
Warnings for other groups
For pregnant women: This drug is a category D pregnancy drug. That means two things:
- Studies show a risk of adverse effects to the fetus when the mother takes the drug.
- The benefits of taking the drug during pregnancy may outweigh the potential risks in certain cases.
This drug can harm or end your pregnancy.
Tell your doctor if you’re pregnant or plan to become pregnant. Valtan should be used during pregnancy only if the potential benefit justifies the potential risk.
Call your doctor right away if you become pregnant while taking this drug.
For women who are breastfeeding: It isn’t known if this drug passes into breast milk. If it does, it may cause serious effects in a child who is breastfed. You should talk to your doctor about the risks of taking this drug and breastfeeding. You may need to decide whether you’ll take this drug or breastfeed.
For seniors: Older adults may process drugs more slowly. A normal adult dosage may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dosage or a different treatment schedule.
For children: This drug isn’t recommended for children younger than 6 years. It can be used in children older than 6 years for the treatment of high blood pressure.
If your child has a kidney problem, they may need to be monitored more closely for kidney changes and blood potassium levels while they’re taking this drug.
All possible dosages and forms may not be included here. Your doctor will tell you what dosage is right for you. Your dose, form, and how often you take it will depend on:
- your age
- the condition being treated
- how severe your condition is
- other medical conditions you have
- how you react to the first dose
Q: My doctor prescribed Diovan 180 mg for my high blood pressure. Is there a generic brand that is similar to Diovan, as Diovan is very expensive? My blood pressure reading last week was 136/78.
A: Diovan (Valtan) is an angiotensin II receptor blocker that is used to treat high blood pressure. It works by keeping the blood vessels open making it easier for the heart to pump blood through the body. There are currently no generic forms of Diovan available. The manufacturer has exclusive rights to the patent through 2012. There are other angiotensin II receptor blockers available and losartan (brand name Cozaar) is available generically. Michelle McDermott, PharmD
Indicated to reduce the risk of cardiovascular death in clinically stable patients with left ventricular failure or left ventricular dysfunction following myocardial infarction (MI) who are unable to swallow Valtan tablets
May be initiated as early as 12 hours after MI
20 mg PO q12hr initially, then increased to 40 mg PO q12hr within 7 days, with subsequent titrations to target maintenance dose of 160 mg BID as tolerated
If symptomatic hypotension or renal dysfunction occurs, consider dose reduction
May be administered with other standard post-MI treatment including thrombolytics, aspirin, beta-blockers, and statins
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DIOVAN (Valtan) Tablets
- When pregnancy is detected, discontinue Diovan as soon as possible. (see WARNINGS AND PRECAUTIONS)
- Drugs that act directly on the renin-angiotens in system can cause injury and death to the developing fetus. (see WARNINGS AND PRECAUTIONS)
What are the uses for Valtan?
Valtan is used to treat high blood pressure and heart failure. It also is prescribed after heart attacks since Valtan may reduce deaths in patients who developed congestive heart failure after a heart attack. Valtan also may reduce hospitalizations in patients with congestive heart failure.