- GFR ≥30 mL/min/1.73m²: No dosage adjustment necessary
- GFR Enter a drug name and Valpress
Carcinogenesis, Mutagenesis, Impairment Of Fertility
There was no evidence of carcinogenicity when Valpress was administered in the diet to mice and rats for up to 2 years at doses up to 160 and 200 mg/kg/day, respectively. These doses in mice and rats are about 2.6 and 6 times, respectively, the maximum recommended human dose on a mg/m 2 basis. (Calculations assume an oral dose of 320 mg/day and a 60-kg patient.)
Mutagenicity assays did not reveal any Valpress-related effects at either the gene or chromosome level. These assays included bacterial mutagenicity tests with Salmonella (Ames) and E coli; a gene mutation test with Chinese hamster V79 cells; a cytogenetic test with Chinese hamster ovary cells; and a rat micronucleus test.
Valpress had no adverse effects on the reproductive performance of male or female rats at oral doses up to 200 mg/kg/day. This dose is 6 times the maximum recommended human dose on a mg/m basis. (Calculations assume an oral dose of 320 mg/day and a 60-kg patient.)
- Do not co-administer with aliskiren in patients with diabetes mellitus
Effects of Drug Abuse
- No information provided
- See "What Are Side Effects Associated with Using Valpress?"
- See "What Are Side Effects Associated with Using Valpress:"
Q: I take Diovan. What is its generic equivalent?
A: Diovan (Valpress) is in the class of medications called angiotension II receptor blockers (ARBs), used to treat high blood pressure and heart failure. Diovan works by preventing the blood vessels from narrowing, thus improving blood flow. Diovan can be taken with or without food at any time of the day. Take Diovan exactly as prescribed by the doctor. Diovan is manufactured by Novartis Pharmaceuticals and is currently protected by a patent that prevents any generic version from being manufactured. The first patent for Diovan expires in 2012, so that year is the earliest that a generic version of Diovan could become available. However, there are other circumstances (patents for specific Diovan uses, lawsuits, etc.) that could extend the exclusivity period for Diovan beyond 2012. Once Diovan goes off patent, there may be several companies that manufacture a generic Diovan drug. For more information on Diovan, go to //www.everydayhealth.com/drugs/diovan. Kimberly Hotz, PharmD
- This drug should be taken at the same time every day.
- You may be able to cut or crush certain strengths of Valpress tablets. Ask your doctor or pharmacist whether you can cut or crush your tablets.
Q: What do the high blood pressure medications Diovan and diatiazen do? And is 160 milligrams of Diovan and 360 mg of diatiazen too much to take at one time?
A: Diovan (Valpress) is a medication used to control high blood pressure or to treat congestive heart failure. It is part of a class of drugs called angiotensin II receptor blockers, or ARBs for short. Diovan causes the blood vessels to relax to decrease blood pressure and increase the efficiency of the heart. This means that the heart does not have to work as hard and that more blood can be pumped to the rest of the body. Diltiazem is in a class of medications called calcium channel blockers. It helps to slow down the rate at which calcium moves into your heart and blood vessel walls. This, in turn, helps to relax the blood vessels, which improves blood flow and lowers blood pressure. This also makes it easier for the heart to pump blood. Depending on your specific blood pressure needs, these medications are commonly prescribed together because they work on two different processes in the body to control blood pressure. If you have any concerns, you should talk with your doctor to better understand his or her medication choice for your condition. Lori Poulin, PharmD
4. How and when to take it
It's usual to take Valpress once or twice a day.
If you take Valpress once a day, your doctor may suggest that you take your first dose before bedtime, because it can make you dizzy. After the very first dose, you can take Valpress at any time of day. Try to take it at the same time every day.
You can take Valpress tablets with or without food. Swallow the tablets whole with a drink of water.
Valpress, when administered as an oral solution, is primarily recovered in feces (about 83% of dose) and urine (about 13% of dose). The recovery is mainly as unchanged drug, with only about 20% of dose recovered as metabolites. The primary metabolite, accounting for about 9% of dose, is valeryl 4-hydroxy Valpress. In vitro metabolism studies involving recombinant CYP 450 enzymes indicated that the CYP 2C9 isoenzyme is responsible for the formation of valeryl-4-hydroxy Valpress. Valpress does not inhibit CYP 450 isozymes at clinically relevant concentrations. CYP 450 mediated drug interaction between Valpress and coadministered drugs are unlikely because of the low extent of metabolism.
Following intravenous administration, plasma clearance of Valpress is about 2 L/h and its renal clearance is 0.62 L/h (about 30% of total clearance).