Shinpral tablets

Shinpral

  • Active Ingredient: Propranolol
  • 80 mg, 40 mg, 20 mg
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What is Shinpral?

The active ingredient of Shinpral brand is propranolol. Propranolol is a beta-blocker. Beta-blockers affect the heart and circulation (blood flow through arteries and veins). Propranolol hydrochloride is a stable, white, crystalline solid which is readily soluble in water and ethanol. Its molecular weight is 295.80. Propranolol Hydrochloride Extended-Release Capsules, USP, are formulated to provide a sustained release of Propranolol hydrochloride. Propranolol Hydrochloride Extended-Release Capsules, USP, are available as 60 mg, 80 mg, 120 mg, and 160 mg capsules for oral administration. Each capsule for oral administration contains sugar spheres, ethylcellulose, hypromellose phthalate, povidone, diethyl phthalate, polyethylene glycol, titanium dioxide, ammonium hydroxide, potassium hydroxide, black iron oxide, and gelatin. The 80 mg, 120 mg, and 160 mg capsules contain red and yellow iron oxide. In addition, the 160 mg capsules contain FD&C Blue No. 2. These capsules comply with USP Dissolution Test 1. Propranolol Hydrochloride Extended-Release Capsules, USP, should not be considered a simple mg-for-mg substitute for conventional Propranolol and the blood levels achieved do not match (are lower than) those of two to four times daily dosing with the same dose (see DOSAGE AND ADMINISTRATION). When changing to Propranolol Hydrochloride Extended-Release Capsules, USP, from conventional Propranolol, a possible need for retitration upwards should be considered, especially to maintain effectiveness at the end of the dosing interval. In most clinical settings, however, such as hypertension or angina where there is little correlation between plasma levels and clinical effect, Propranolol Hydrochloride Extended-Release Capsules, USP, have been therapeutically equivalent to the same mg dose of conventional Propranolol as assessed by 24-hour effects on blood pressure and on 24-hour exercise responses of heart rate, systolic pressure, and rate pressure product. Effects of Propranolol on plasma volume appear to be minor and somewhat variable. In angina pectoris, Propranolol generally reduces the oxygen requirement of the heart at any given level of effort by blocking the catecholamine-induced increases in the heart rate, systolic blood pressure, and the velocity and extent of myocardial contraction. Propranolol may increase oxygen requirements by increasing left ventricular fiber length, end diastolic pressure, and systolic ejection period. The net physiologic effect of beta-adrenergic blockade is usually advantageous and is manifested during exercise by delayed onset of pain and increased work capacity. Propranolol exerts its antiarrhythmic effects in concentrations associated with beta-adrenergic blockade, and this appears to be its principal antiarrhythmic mechanism of action. In dosages greater than required for beta blockade, Propranolol also exerts a quinidine-like or anesthetic-like membrane action which affects the cardiac action potential. The significance of the membrane action in the treatment of arrhythmias is uncertain. The mechanism of the anti-migraine effect of Propranolol has not been established. Beta-adrenergic receptors have been demonstrated in the pial vessels of the brain.

Used for

Shinpral is used to treat diseases such as: Angina, Anxiety, Aortic Stenosis, Arrhythmia, Atrial Fibrillation, Benign Essential Tremor, Heart Attack, Hemangioma, High Blood Pressure, Intermittent Explosive Disorder, Migraine Prevention, Mitral Valve Prolapse, Panic Disorder, Performance Anxiety, Pheochromocytoma, Portal Hypertension, Tardive Dyskinesia, Thyrotoxicosis, Ventricular Tachycardia.

Side Effect

Possible side effects of Shinpral include: body aches or pain; Decreased appetite; blurred or loss of vision; blistering, peeling, or loosening of the skin; depersonalization; dysphoria.

How to Buy Shinpral tablets online?

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Which drugs or supplements interact with Shinpral?

Calcium channel blockers and digoxin (Lanoxin) can lower blood pressure and heart rate to dangerous levels when administered together with Shinpral. Shinpral can mask the early warning symptoms of low blood sugar (hypoglycemia) and should be used with caution in patients receiving treatment for diabetes. Shinpral reduces the metabolism of thioridazine (Mellaril), increasing the concentration of thioridazine in the body and potentially causing abnormal heartbeats.

What Other Drugs Interact with Shinpral (Zovirax)?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of this medicine or any drug before seeking medical advice from your doctor, healthcare provider or pharmacist first. To do so may result in serious consequences or side effects.

Shinpral has no known severe interactions with other drugs.

Shinpral has serious interactions with at least 39 different drugs.

Shinpral has moderate interactions with at least 246 different drugs.

Shinpral has mild interactions with at least 35 different drugs.

Shinpral has mild interactions with at least 65 different drugs.This document does not contain all possible interactions from the use of this medication. Therefore, before using this drug, tell your doctor or pharmacist of all the drugs you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

Is Shinpral safe to take while pregnant or breastfeeding?

Safe use during pregnancy has not been established. Growth retardation and congenital abnormalities have been reported in infants whose mothers received Shinpral during pregnancy. Infants whose mothers received Shinpral during labor have exhibited slow heart rate, hypoglycemia, and/or respiratory depression.

Shinpral is secreted into breast milk. It should be avoided or used with caution in nursing women.

How to take Shinpral

  • Before you start the treatment, read the manufacturer's printed information leaflet from ins >

Shinpral with Food

Food can enhance the levels of Shinpral in your body. You shoud take Shinpral at the same time each day, preferably with or immediately following meals. This will make it easier for your body to absorb the medication. Avoid drinking alcohol, which could increase drowsiness and dizziness while you are taking Shinpral. Shinpral is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately or get emergency medical treatment:

  • difficulty breathing or swallowing
  • rash
  • blistering or peeling skin
  • hives
  • itching
  • swelling of the face, throat, tongue, or lips
  • feeling faint
  • weight gain
  • irregular heartbeat

Shinpral may cause other side effects. Call your doctor if you have any unusual problems while you are using this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).


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