In a study of systemic hemodynamic function measured invasively in 12 patients with a mean LV ejection fraction of 37% and ventricular tachycardia (9 sustained and 3 non-sustained), a median dose of 160 mg twice daily of Rytmobeta hydrochloride produced a 28% reduction in heart rate and a 24% decrease in cardiac index at 2 hours post dosing at steady-state. Concurrently, systemic vascular resistance and stroke volume showed nonsignificant increases of 25% and 8%, respectively. Pulmonary capillary wedge pressure increased significantly from 6.4 mmHg to 11.8 mmHg in the 11 patients who completed the study. One patient was discontinued because of worsening congestive heart failure. Mean arterial pressure, mean pulmonary artery pressure and stroke work index did not significantly change. Exercise and isoproterenol induced tachycardia are antagonized by Rytmobeta, and total peripheral resistance increases by a small amount.
In hypertensive patients, Rytmobeta hydrochlor >WARNINGS, Congestive Heart Failure ).
Pregnancy and Rytmobeta
This drug isn't likely to harm an unborn baby.
However, talk to your doctor if you're pregnant or might become pregnant before taking Rytmobeta.
Rytmobeta is found in breast milk. Don't breastfeed while taking this medicine.
Rytmobeta has only modest efficacy in maintaining NSR (30% to 50% at 1 year). Rytmobeta causes drug-induced QT prolongation and torsades de pointes, especially in the setting of renal failure, hypokalemia, or the concomitant use of other QT-prolonging drugs. Therefore Rytmobeta is often initiated in an inpatient setting with ECG monitoring to observe for excessive QT prolongation and proarrhythmia, especially when the drug is initiated during AF. However, drug initiation in an outpatient setting is also common, especially in low-risk patients with no underlying structural heart disease, QTc less than 450 milliseconds, normal electrolytes and renal function, and are in NSR at the time of drug initiation. Rytmobeta can be used in patients with ischemic heart disease, but should be avoided in patients with marked LV hypertrophy and those with renal insufficiency.
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your blood pressure should be checked regularly to determine your response to Rytmobeta. Your doctor may ask you to check your pulse (heart rate). Ask your pharmacist or doctor to teach you how to take your pulse. If your pulse is faster or slower than it should be, call your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
COMMON BRAND(S): Betapace, Betapace AF
GENERIC NAME(S): Rytmobeta
OTHER NAME(S): Rytmobeta Tablet
Rytmobeta should be used only in certain patients. Before taking Rytmobeta, discuss the risks and benefits of treatment with your doctor. Although Rytmobeta is effective for treating certain types of fast/irregular heartbeats, it can rarely cause a new serious abnormal heart rhythm (QT prolongation in the EKG). This problem can lead to a new type of abnormal (possibly fatal) heartbeat (torsade de pointes). If this new serious heart rhythm occurs, it is usually when Rytmobeta treatment is first started or when the dose is increased. Therefore, to reduce the risk of this side effect, you should begin Rytmobeta treatment in a hospital so your doctor can monitor your heart rhythm for several days and treat the problems if they occur. Patients usually start with a low dose of Rytmobeta. Your doctor will then slowly increase your dose depending on how you respond to the medication and how well your kidneys work. If you respond well to this medication, during this time in the hospital your doctor can determine the right dose of Rytmobeta for you.
Some Rytmobeta products are used to treat certain types of fast/irregular heartbeats (atrial fibrillation/flutter). These products come with additional written information from the manufacturer for patients with atrial fibrillation/flutter. If you have these conditions, read the provided information carefully. Do not switch brands of Rytmobeta without checking with your doctor.
Do not stop taking this medication without consulting your doctor. Some conditions may become worse when you suddenly stop this drug. Some people who have suddenly stopped taking similar drugs have had chest pain, heart attack, and irregular heartbeat. If your doctor decides you should no longer use this drug, he or she may direct you to gradually decrease your dose over 1 to 2 weeks.
When gradually stopping this medication, it is recommended that you temporarily limit physical activity to decrease strain on the heart. Seek immediate medical attention if you develop: chest pain/tightness/pressure, chest pain spreading to the jaw/neck/arm, unusual sweating, trouble breathing, fast/irregular heartbeat.
This medication is used to treat a serious (possibly life-threatening) type of fast heartbeat called sustained ventricular tachycardia. It is also used to treat certain fast/irregular heartbeats (atrial fibrillation/flutter) in patients with severe symptoms such as weakness and shortness of breath. Rytmobeta helps to lessen these symptoms. It slows the heart rate and helps the heart to beat more normally and regularly. This medication is both a beta blocker and an anti-arrhythmic.
Can Rytmobeta cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with Rytmobeta. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.
Urgent advice: Call your doctor or go to A&E straight away if you take too much Rytmobeta by accident
If you go to a hospital accident and emergency (A&E) department, do not drive yourself - get someone else to drive you or call for an ambulance.
Take the Rytmobeta packet, or the leaflet inside the packet, plus any remaining medicine with you.
Like all medicines, Rytmobeta can cause side effects in some people but many people have no side effects or only minor ones. Side effects often improve as your body gets used to the medicine.
What other drugs will affect Rytmobeta?
Tell your doctor about all your other medicines, especially:
other heart medications;
blood pressure medication; or
insulin or oral diabetes medicine.
This list is not complete. Other drugs may affect Rytmobeta, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Brief Answer:Yes milk and dairy has to be taken after two hours
Detailed Answer:You are correct, Rytmobeta has to be taken on empty stomach.Dairy products have calcium which reduces the absorption of most drugs. So Rytmobeta is something which comes into this category.You can take hot tea/green tea without milk in it.
Let me know if you have any queries.
How should I take Rytmobeta?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Rytmobeta oral is taken by mouth. Rytmobeta injection is given as an infusion into a vein. A healthcare provider will give you this injection if you are unable to take the medicine by mouth.
You will receive your first few doses of Rytmobeta in a hospital setting where your heart can be monitored in case the medicine causes serious side effects.
If you already take heart rhythm medication, you may need to stop taking it when you start using Rytmobeta. Carefully follow your doctor's instructions.
Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
Rytmobeta doses are based on age and body surface area (height and weight) in children. Your child's dose needs may change if the child gains or loses weight, or is still growing.
Call your doctor if you are sick with vomiting or diarrhea, or if you have increased thirst, decreased appetite, or are sweating more than usual. You can easily become dehydrated while taking Rytmobeta. This can lead to very low blood pressure, a serious electrolyte imbalance, or kidney failure.
You will need frequent medical tests. Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG). You may also need heart function tests for 1 to 2 weeks after your last dose.
Keep using this medicine as directed, even if you feel well. You may need to take Rytmobeta for the rest of your life.
Do not skip doses or stop using Rytmobeta without your doctor's advice. Stopping suddenly may make your condition worse. Follow your doctor's instructions about tapering your dose.
If you need surgery, tell your surgeon you currently use this medicine.
Store at room temperature away from moisture and heat. Do not allow liquid medicine to freeze.
Your pharmacist may prepare an oral suspension (liquid) form of Rytmobeta. Keep the suspension at room temperature and throw away suspension any left over after 3 months of use.
Rytmobeta and Other Interactions
Rytmobeta may cause drowsiness.
Don't drive a car or operate machinery until you know how the medicine affects you.
What Other Drugs Interact with Rytmobeta?
If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
Rytmobeta has severe interactions with at least 56 different drugs.
Rytmobeta has serious interactions with at least 65 different drugs.
Rytmobeta has moderate interactions with at least 189 different drugs.
Rytmobeta has mild interactions with at least 34 different drugs.
This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.
What Is Rytmobeta (Betapace)?
Rytmobeta is the generic form of the brand-name drug Betapace, used to treat a serious irregular heartbeat (arrhythmia).
The prescription medicine is in a class of drugs known as anti-arrhythmics. It works by helping the heart muscle beat regularly for a longer amount of time.
The Food and Drug Administration (FDA) originally approved a formulation of Rytmobeta in 1992.
The medicine is manufactured as Betapace by Bayer HealthCare Pharmaceuticals.
Rytmobeta hydrochlor >12 H 20 N 2 0 3 S•HCl and is represented by the following structural formula: