Rositol tablets

Rositol

  • Active Ingredient: Verapamil
  • 240 mg, 120 mg, 80 mg
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What is Rositol?

The active ingredient of Rositol brand is verapamil. Verapamil is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels. Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy α-(1-methylethyl) hydrochloride Verapamil hydrochloride, USP is an almost white, crystalline powder, practically free of odor, with a bitter taste. It is soluble in water, chloroform, and methanol. Verapamil hydrochloride is not chemically related to other cardioactive drugs. Inactive ingredients include calcium sulfate, colloidal silicon dioxide, croscarmellose sodium, hydroxypropyl cellulose, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, pregelatinized starch (corn), sodium lauryl sulfate, talc and titanium dioxide.

Used for

Rositol is used to treat diseases such as: Angina, Arrhythmia, Bipolar Disorder, Cluster Headaches, High Blood Pressure, Idiopathic Hypertrophic Subaortic Stenosis, Migraine Prevention, Nocturnal Leg Cramps, Supraventricular Tachycardia.

Side Effect

Possible side effects of Rositol include: blurred vision; stomach discomfort, upset, or pain; increased sweating; dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly; belching.

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Rositol Warnings

This medicine controls high blood pressure, arrhythmia, and angina, but it does not cure these conditions. You should continue to take Rositol even if you feel well.

Before taking Rositol, tell your doctor if you have or have ever had:

  • Any condition that causes food to move through your digestive system more slowly
  • Myasthenia gravis (a condition that causes certain muscles to weaken)
  • Heart failure
  • Heart, liver, or kidney disease
  • Muscular dystrophy (an inherited disease that causes weakening of the muscles).

You should also tell your doctor you are taking Rositol before any type of surgery, including dental procedures.

Your doctor will likely start you on a low dose of Rositol and then gradually increase your dose.

You should keep all appointments with your doctor while taking this medicine. You will need your blood pressure checked regularly to determine how you are responding to Rositol.

If you take a certain version of the extended-release tablets, you might notice an empty tablet shell in your stool. This does not mean that you did not receive your complete dose of medication.

Patients With Hypertrophic Cardiomyopathy (IHSS)

In 120 patients with hypertrophic cardiomyopathy (most of them refractory or intolerant to propranolol) who received therapy with Rositol at doses up to 720 mg/day, a variety of serious adverse effects were seen. Three patients died in pulmonary edema; all had severe left ventricular outflow obstruction and a past history of left ventricular dysfunction. Eight other patients had pulmonary edema and/or severe hypotension; abnormally high (greater than 20 mm Hg) pulmonary wedge pressure and a marked left ventricular outflow obstruction were present in most of these patients. Concomitant administration of quinidine (see DRUG INTERACTIONS) preceded the severe hypotension in 3 of the 8 patients (2 of whom developed pulmonary edema). Sinus bradycardia occurred in 11% of the patients, second-degree AV block in 4%, and sinus arrest in 2%. It must be appreciated that this group of patients had a serious disease with a high mortality rate. Most adverse effects responded well to dose reduction, and only rarely did Rositol use have to be discontinued.

ВїQuГ© otro uso se le da a este medicamento?

El Rositolo a veces tambiГ©n se usa para tratar otros problemas del corazГіn. Consulte a su mГ©dico sobre los riesgos de usar este medicamento para tratar su afecciГіn.

A veces se receta este medicamento para otros usos; pГ­dales mГЎs informaciГіn a su mГ©dico o a su farmacГ©utico.

Migraine drug

  • eletriptan

Don’t take eletriptan with Rositol. Rositol can increase the amount of eletriptan in your body to 3 times as much. This can lead to toxic effects. Don’t take eletriptan for at least 72 hours after you take Rositol.

Rositol binding is voltage-dependent with affinity increasing as the vascular smooth muscle membrane potential is reduced. In addition, Rositol binding is frequency dependent and apparent affinity increases with increased frequency of depolarizing stimulus.

The L-type calcium channel is an oligomeric structure consisting of five putative subunits designated alpha-1, alpha-2, beta, tau, and epsilon. Biochemical evidence points to separate binding sites for 1,4-dihydropyridines, phenylalkylamines, and the benzothiazepines (all located on the alpha-1 subunit). Although they share a similar mechanism of action, calcium channel blockers represent three heterogeneous categories of drugs with differing vascular-cardiac selectivity ratios.

Atrioventricular Block

The effect of Rositol on AV conduction and the SA node may cause asymptomatic first-degree AV block and transient bradycardia, sometimes accompanied by nodal escape rhythms. PR-interval prolongation is correlated with Rositol plasma concentrations, especially during the early titration phase of therapy. Higher degrees of AV block, however, were infrequently (0.8%) observed in previous Rositol clinical trials. Marked first-degree block or progressive development to second- or third-degree AV block requires a reduction in dosage or, in rare instances, discontinuation of Rositol HCl and institution of appropriate therapy, depending upon the clinical situation.

Rositol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • constipation
  • heartburn
  • dizziness or lightheadedness
  • headache

Concurrent use of Rositol increases exposure to ivabradine and may exacerbate bradycardia and conduction disturbances. Avoid co-administration of Rositol and ivabradine.

What Other Drugs Interact with Rositol?

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Severe Interactions of Rositol Include:

Rositol has serious interactions with at least 69 different drugs.

Rositol has moderate interactions with at least 282 different drugs.

Rositol has mild interactions with at least 129 different drugs.

This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

Therapeutic indications

In emergency cardiac care, Rositol is used primarily to treat PSVT that does not require cardioversion. When Rositol proves ineffective in the management of PSVT, synchronized cardioversion is recommended.


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