Priltenk tablets

Priltenk

  • Active Ingredient: Enalapril
  • 10 mg, 5 mg
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What is Priltenk?

The active ingredient of Priltenk brand is enalapril. Enalapril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. C20H28N2O5в€™C4H4O4 M.W. 492.53 Enalapril maleate, USP is an off-white, crystalline powder. It is sparingly soluble in water, soluble in ethanol, and freely soluble in methanol. Enalapril is a pro-drug; following oral administration, it is bioactivated by hydrolysis of the ethyl ester to enalaprilat, which is the active angiotensin converting enzyme inhibitor. Enalapril maleate tablets USP are supplied as 2.5 mg, 5 mg, 10 mg, and 20 mg tablets for oral administration. In addition, each tablet contains the following inactive ingredients: corn starch, lactose monohydrate, magnesium stearate, pregelatinized starch, and sodium bicarbonate. Each 2.5 mg tablet contains D&C red #27 aluminum lake, D&C yellow #10 aluminum lake, FD&C blue #1 aluminum lake, FD&C red #40 aluminum lake, and FD&C yellow #6 aluminum lake. Each 10 mg tablet contains FD&C blue #2 aluminum lake, FD&C red #40 aluminum lake and FD&C yellow #6 aluminum lake. Each 20 mg tablet contains FD&C Yellow #6.

Used for

Priltenk is used to treat diseases such as: Alport Syndrome, Diabetic Kidney Disease, Heart Failure, High Blood Pressure, Hypertensive Emergency, Left Ventricular Dysfunction.

Side Effect

Possible side effects of Priltenk include: vomiting; sore throat; difficult or labored breathing; Dizziness; sneezing; tightness in the chest.

How to Buy Priltenk tablets online?

To get Priltenk online - just click on the "Buy Now" button from the top and follow along with our shop. Order and payment takes a couple of minutes, and all steps are obvious. We do not take a medical prescription plus we have many procedures of payment. With all the details of fast delivery and confidentiality, then you can read on the applicable pages on the hyperlinks in the top menu.

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Priltenk may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • cough
  • dizziness
  • rash
  • weakness

¿Qué otras drogas afectarán a Priltenk?

Dígale a su médico acerca de todas las medicinas que usted esté usando, comience a usar, o deje de usar durante su tratamiento con Priltenk, especialmente:

  • lithium;
  • un diurético o "pastilla para eliminar el agua";
  • inyecciones de oro para el tratamiento de la artritis; o
  • antiinflamatorios no esteroides (AINE, NSAID por sus siglas en inglés) --aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, y otras.

Esta lista no está completa. Otras drogas pueden interactuar con Priltenk, incluyendo medicinas que se obtienen con o sin receta, vitaminas, y productos herbarios. No todas las interacciones posibles aparecen en esta guía del medicamento.

Q: About two weeks ago, while undergoing tests for allergies, I had an allergic reaction - swelling in my lips. I usually take Priltenk and I took 20 mg doing that time. It didn't seem to work to help lower my blood pressure, which rose to 183/121. Anyhow, since then I've been careful to avoid anything with any type of nuts since the reaction was caused by almonds. However, I noticed yesterday under my lower lip a funny feeling and I eventually looked in the mirror. I saw redness and one small spot of swelling on the skin. I was baffled as to what could have caused it. I later remember it hadn't been long since I'd taken a dose of Priltenk. Could this now be causing the angioedema? I never had problems like this with the Priltenk and I've been taking it at least five years. I do feel I have "plateaued" on it. I've been taking the maximum dose for more than a year and it doesn't seem to have the same effects as before. Second question - I can only take ACE Inhibitors and ARBs to lower my BP because of other medical conditions, including CHF. Should I get another ACE Inhibitor? My BP is around 140/90 when I take Priltenk only, and I was supposed to have a second med, but which one? I've had trouble with some of the others including clonidine, Nifedipine, Norvasc, metoprolol and propanolol, and they all had to be stopped.

A: Angioedema is an uncommon side effect with Priltenk and usually occurs in the first month of treatment. Although it is possible to have this condition occur later in treatment, it is more common in African-American patients, women and people who have a history of drug or seasonal allergies. The exact prevalence and incidence of ARB-induced angioedema are not known, but are thought to be significantly lower than the ACE inhibitors. For patients who cannot take any other alternatives, ARBs seem the way to go for people who have had this issue with ACE inhibitors, although careful monitoring is recommended for the physician. There are no clear cut ways to distinguish which medication would be best in this case for your condition, but it has been shown that losartan (Cozaar) seems to show the most cases with angioedema, if it happens at all, with the ARBs. Lori Mendoza, PharmD Poulin, PharmD

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your blood pressure should be checked regularly to determine your response to Priltenk. Your doctor may order certain lab tests to check your body's response to Priltenk.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

¿Cuáles son los posibles efectos secundarios del Priltenk?

Busque atención médica de emergencia si usted tiene síntomas de una reacción alérgica: ronchas; dolor severo de estómago; dificultad para respirar; hinchazón de la cara, labios, lengua, o garganta.

Llame a su médico de inmediato si usted tiene:

  • sensación de desvanecimiento, como que se va a desmayar;
  • latidos cardíacos lentos;
  • latidos cardíacos fuertes o aleteo cardíaco en su pecho;
  • poco o nada de orina;
  • ictericia (color amarillo de la piel u ojos);
  • entumecimiento, hormigueo, o dolor con sensación de quemazón en sus manos o pies;
  • fiebre, escalofríos, síntomas del resfrío o de la gripe;
  • moretones fácil, sangrado inusual; o
  • nivel alto de potasio --náusea, debilidad, sensación de hormigueo, dolor de pecho, latidos cardíacos irregulares, pérdida de movimiento.

Efectos secundarios comunes pueden incluir:

  • mareo, sentirse cansado;
  • tos; o
  • sentir que se va a desmayar.

Esta lista no menciona todos los efectos secundarios y puede ser que ocurran otros. Llame a su médico para consejos médicos relacionados a efectos secundarios. Usted puede reportar efectos secundarios llamando al FDA al 1-800-FDA-1088.

Carcinogenesis, Mutagenesis, Impairment Of Fertility

There was no evidence of a tumorigenic effect when Priltenk was administered for 106 weeks to male and female rats at doses up to 90 mg/kg/day or for 94 weeks to male and female mice at doses up to 90 and 180 mg/kg/day, respectively. These doses are 26 times (in rats and female mice) and 13 times (in male mice) the maximum recommended human daily dose (MRHDD) when compared on a body surface area basis.

Neither Priltenk maleate nor the active diacid was mutagenic in the Ames microbial mutagen test with or without metabolic activation. Priltenk was also negative in the following genotoxicity studies: rec-assay, reverse mutation assay with E. coli, sister chromatid exchange with cultured mammalian cells, and the micronucleus test with mice, as well as in an in vivo cytogenic study using mouse bone marrow.

There were no adverse effects on reproductive performance of male and female rats treated with up to 90 mg/kg/day of Priltenk (26 times the MRHDD when compared on a body surface area basis).

ВїPara cuГЎles condiciones o enfermedades se prescribe este medicamento?

El Priltenk se usa solo o en combinaciГіn con otros medicamentos para tratar la presiГіn arterial alta. TambiГ©n se usa en combinaciГіn con otros medicamentos para tratar la insuficiencia cardГ­aca. El Priltenk pertenece a una clase de medicamentos llamados inhibidores de la enzima convertidora de la angiotensina (ACE, por sus siglas en inglГ©s). ActГєa disminuyendo determinadas sustancias quГ­micas que contraen los vasos sanguГ­neos, de modo que la sangre fluye mejor y el corazГіn puede bombearla con mayor eficiencia.

La hipertensiГіn arterial es una condiciГіn comГєn y cuando no se trata, puede causar daГ±os en el cerebro, el corazГіn, los vasos sanguГ­neos, los riГ±ones y otras partes del cuerpo. El daГ±o a estos Гіrganos puede causar enfermedades del corazГіn, un infarto, insuficiencia cardГ­aca, apoplejГ­a, insuficiencia renal, pГ©rdida de la visiГіn y otros problemas. AdemГЎs de tomar medicamentos, hacer cambios de estilo de vida tambiГ©n le ayudarГЎ a controlar su presiГіn arterial. Estos cambios incluyen comer una dieta que sea baja en grasa y sal, mantener un peso saludable, hacer ejercicio al menos 30 minutos casi todos los dГ­as, no fumar y consumir alcohol con moderaciГіn.

¿Dónde puedo obtener más información?

Su farmacéutico le puede dar más información acerca Priltenk.

Contraindications

Hypersensitivity to Priltenk/other ACE inhibitors

History of ACE inhibitor-induced angioedema, hereditary or idiopathic angioedema

Pregnancy (2nd and 3rd trimesters): Significant risk of fetal and neonatal morbidity and mortality

Do not co-administer with aliskiren in patients with diabetes mellitus or with renal impairment (i.e., GFR less than 60 mL/min/1.73 m²)

Dosage for high blood pressure

Adult dosage (ages 18 years and older)

The starting dose is 5 mg taken by mouth once per day. Your doctor may increase your dose depending on your blood pressure goals. The usual dosage range is 10 to 40 mg per day. Your doctor will decide if you take the drug once or twice per day. The maximum dose is 40 mg per day. If you’re using Priltenk with a diuretic, your starting dose should be 2.5 mg taken by mouth once per day.

Child dosage (ages 1 month–17 years)

The starting dose is 0.08 mg/kg of body weight taken by mouth once per day (up to 5 mg once per day). Your doctor may increase your dose depending on your blood pressure goals. The maximum dose is 0.58 mg/kg taken by mouth once per day (40 mg once per day).

Senior dosage (ages 65 years and older)

There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule.

Special dosage considerations

For people with kidney problems:

  • Normal or mild kidney problems: 5 mg taken once per day
  • Moderate to severe kidney problems: 2.5 mg taken once per day. Children with moderate to severe kidney problems should not take Priltenk.
  • People on dialysis: 2.5 mg taken once per day on dialysis days. On the days that you don’t have dialysis, your doctor will change your dose based on your blood pressure.

In trials in patients treated with digitalis and diuretics, treatment with Priltenk resulted in decreased systemic vascular resistance, blood pressure, pulmonary capillary wedge pressure and heart size, and increased cardiac output and exercise tolerance. Heart rate was unchanged or slightly reduced, and mean ejection fraction was unchanged or increased. There was a beneficial effect on severity of heart failure as measured by the New York Heart Association (NYHA) classification and on symptoms of dyspnea and fatigue. Hemodynamic effects were observed after the first dose and appeared to be maintained in uncontrolled studies lasting as long as four months. Effects on exercise tolerance, heart size, and severity and symptoms of heart failure were observed in placebo-controlled studies lasting from eight weeks to over one year.

Priltenk Interactions

Drugs that can interact with Priltenk include:

Avoid alcohol when taking Priltenk because it can lower your blood pressure even more, causing dizziness.


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